Pathology Research and Practice
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#2Ioanna GiannopoulouH-Index: 24
Last. I Thymara (National and Kapodistrian University of Athens)H-Index: 8
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#1Zheng-Yan Zhang (Fudan University)H-Index: 4
#2Shi-Long Zhang (Fudan University)H-Index: 4
Last. Bing Han (Fudan University)H-Index: 8
view all 9 authors...
Abstract null null Clear cell renal cell carcinoma (ccRCC) is resistant to conventional therapy due to the deletion of the von Hippel-Lindau (VHL) gene, and novel treatment options are urgently needed. Here, using tissue microarray analysis of 445 cancer tissues and 326 adjacent normal renal tissues obtained from patients with ccRCC, we present the early growth response-1 (EGR1) protein levels are significantly decreased in ccRCC cancer tissues. Consistently, the EGR1 mRNA expression also decrea...
#1E. Pretzsch (LMU: Ludwig-Maximilians-Universität München)H-Index: 1
#2Christopher Lampert (LMU: Ludwig-Maximilians-Universität München)H-Index: 4
Last. Florian Bösch (LMU: Ludwig-Maximilians-Universität München)H-Index: 9
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Abstract null null Background null In gastric cancer (GC), extracapsular growth (ECG) pattern of lymph node metastases is associated with decreased overall survival rates compared to intracapsular lymph node metastases (ICG). Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in hematogenous metastatic spread. Aim of the present study was to analyze if EMT related genes are involved in the growth pattern of lymph node metastases in GC. null null null Methods null Out of our prospect...
#1Yuchen Jin (WUT: Wuhan University of Technology)
#2Linghan Meng (WUT: Wuhan University of Technology)
Last. Bifeng Chen (WUT: Wuhan University of Technology)H-Index: 6
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ABSTRACT null null To examine the role of IL-22 gene in colorectal cancer (CRC) susceptibility, we identified causative genetic polymorphisms in promoter region of IL-22 gene and explored the mechanism underlying their contribution to CRC development in a Chinese population of Hubei province. 13 target single nucleotide polymorphisms (SNPs) in IL-22 gene promoter were genotyped in 787 CRC patients (426 colon cancer and 361 rectal cancer) and 800 normal controls. The results demonstrated that the...
#1Thomas W. Bauer (HSS: Hospital for Special Surgery)H-Index: 81
#2Yaxia Zhang (HSS: Hospital for Special Surgery)H-Index: 6
Last. Matthew F. Koff (HSS: Hospital for Special Surgery)H-Index: 21
view all 5 authors...
Abstract null null Background null Several previous studies have described broad histologic classifications of peri-prosthetic reactions that likely reflect the underlying mechanism of arthroplasty failure; however, a consensus has not yet been reached about the relative importance of individual observations. null null null Question/Purpose null The purpose of this study was to evaluate the inter-examiner repeatability of commonly used histopathologic grading methods, and to determine the utilit...
#1Bao S (SDU: Shandong University)
#2Ji Z (SDU: Shandong University)
Last. Liu X (SDU: Shandong University)
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Abstract null null Background null Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors worldwide and is characterized by activation of epithelial-mesenchymal transition (EMT). EPB41L5 is regarded as a key factor in the progression of EMT and metastasis in various kinds of cancers, although the role and mechanism of EPB41L5 in ESCC have not yet been elucidated. In addition, tumor cells can acquire enhanced aggressiveness and a mesenchymal phenotype through phospho...
#1Hongxing Nan (Shihezi University)
#2Lisha Zhou (Shihezi University)H-Index: 1
Last. Lianghai Wang (Shihezi University)H-Index: 10
view all 8 authors...
Abstract null null Chemokines have distinct effects on tumor progression by affecting cancer immunity and tumorigenesis. However, the characteristic chemokine profiles and their roles in immune cell recruitment and cancer cell biology are not entirely understood in esophageal cancer. Here, we scrutinized chemokine's expression profiles in independent esophageal cancer cohorts and identified the elevated CCL20 as a risk factor to predict patients' prognosis regardless of histology subtypes. Enhan...
Abstract null null Background null The prognosis of squamous cell carcinoma of head and neck (HNSCC) patients remains relatively poor over the last years. Tobacco, alcohol and active human papillomavirus (HPV) infection are involved in HNSCC development. Akt is a serine-threonine protein kinase with main phosphorylation sites at Thr308 and Ser473, which are critical to generate a high level of Akt activity. null null null Materials and methods null The aim of the study was to compare the express...
#1Guifeng Zhang (FJMU: Fujian Medical University)H-Index: 2
#2Jiangming Zhong (FJMU: Fujian Medical University)H-Index: 2
Last. Zhenhua Liu (FJMU: Fujian Medical University)H-Index: 2
view all 4 authors...
Abstract null null Background null ATP Synthase F1 Subunit Alpha (ATP5F1A), also named as ATP5A1, is a subunit of mitochondrial ATP synthase. Dysregulated expression of ATP5A1 has been reported in several malignancies, nevertheless it showed either oncogenic or tumor-suppressing roles in different cancer types. Here we aimed to initially investigate the expression and role of ATP5A1 in colon adenocarcinoma. null null null Methods null We firstly evaluated the transcription and mRNA levels of ATP...
#1Haomiao Zhou (Nantong University)H-Index: 1
#2Tingting Bian (Nantong University)H-Index: 7
Last. Xiaoli Li (Nantong University)H-Index: 4
view all 12 authors...
BACKGROUND Lung adenocarcinoma (LUAD) is still one of the primary malignant diseases leading to higher mortality worldwide. It has been previously reported that multiple genes in the CENPA-nucleosome associated complex (NAC) complex in lung cancer can be used as prognostic markers; however, there is lack of comprehensive research on the CENPA-NAC complex. METHODS The hub genes of lung cancer were obtained by analyzing multiple gene expression omnibus (GEO) lung cancer datasets. The key genes of ...
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