Abstract null null Introduction null : The discrimination performance of Bellmunt risk score for immune checkpoint inhibitor (ICI) therapy is largely unknown. This study aimed to validate and enhance discrimination of the Bellmunt score in patients with urothelial carcinoma treated with ICIs. null null null Patients and methods null : Cox proportional hazard analysis was used to validate overall survival (OS) discrimination performance of Bellmunt score in patients with urothelial carcinoma trea...
Last. Brian C. Baumann(WUSTL: Washington University in St. Louis)H-Index: 16
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Abstract null null Background null : Prostate stereotactic body radiotherapy (SBRT), which delivers high-dose precision treatment in ≤5 fractions, is a shorter, more convenient, and less expensive alternative to conventionally fractionated radiotherapy (CRFT; ∼44 fractions) or moderately hypofractionated radiotherapy (MFRT; 20-28 fractions). SBRT has not been widely adopted but may have radiobiologic advantages over CFRT/MFRT. We hypothesized that SBRT would be associated with improved overall s...
#2Yen Cheng Chen(TMU: Taipei Medical University)H-Index: 8
Last. Yuh-Mou Sue(TMU: Taipei Medical University)H-Index: 6
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Abstract null null Background null To investigate the age and gender differences among chronic dialysis patients who developed genitourinary cancers in Taiwan. null null null Patients and Methods null Incident hemodialysis patients aged 20 years or older were selected for retrospective cohort study from the National Health Insurance Research Database between 2002 and 2015, and the Taiwan Cancer Registry Database between 2007 and 2015. A two-step approach was employed to find the respective match...
Last. Michael J. Whalen(GWU: George Washington University)H-Index: 37
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Abstract null null Introduction null : Up to 33% of bladder urothelial carcinoma has variant histology (VH), which is associated with a higher incidence occult regional lymph node metastasis. Neoadjuvant chemotherapy (NAC) is the gold-standard for resectable cT2-4 disease as it achieves pathologic complete response (pCR) in select patients at the time of radical cystectomy (RC). A landmark trial demonstrated chemosensitivity and pT0 status in the setting of VH. pT0N+ pathology in patients underg...
Abstract null null Objectives null To systematically evaluates the evidence on ethnic differences in age-adjusted reference values of PSA. null null null Materials and Methods null In concordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement, a review of English articles using Medline, Embase and Cochrane databases, from inception to December 2019 was conducted. Studies that reported the PSA upper reference value as 95th percentile of the cohort di...
Last. Stacy Loeb(VHA: Veterans Health Administration)H-Index: 56
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Abstract null null Background null Prostate cancer (PCA) germline testing (GT) is now standard-of-care for men with advanced PCA. Thousands of men may consider GT due to clinical and family history (FH) features. Identifying and consenting men for GT can be complex. Here we identified barriers and facilitators of GT across a spectrum of providers which informed the development of Helix – an educational and clinical/FH collection tool to facilitate GT in practice. null null null Materials and Met...
#2Eder Ilario(USP: Universidade de São Paulo)H-Index: 1
Last. William C. Nahas(USP: Universidade de São Paulo)H-Index: 20
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Abstract null null To evaluate the association of neutrophil-to-lymphocyte ratio (RNL) with overall survival (OS) and tumor recurrence (RFS) in patients with locally advanced non-metastatic clear cell renal cell carcinoma (ccRCC) undergoing radical nephrectomy (RN). We retrospectively identified 880 nephrectomies performed between January 2009 and December 2016 in a single center, reviewed data from 478 consecutive radical nephrectomies (RN) for kidney tumors and identified 187 patients with loc...
Abstract null null Purpose null There was a high medical need for patients with non-metastatic castration-resistant prostate cancer (nmCRPC) when several next-generation anti-androgens (apalutamide, enzalutamide, and darolutamide) demonstrated clinically relevant delays in metastasis onset. However, to date, few publications have assessed the pooled effect of these treatments on overall survival (OS). null null null Materials and methods null We performed a systematic review and meta-analysis of...
Abstract null null Micro-abstract null The optimal first-line chemotherapy regimen and dose adjustment for cisplatin-unfit patients with advanced urothelial carcinoma remains unclear in the era of immune checkpoint inhibitors. We investigated the association between response to first-line chemotherapy and response to subsequent pembrolizumab treatment, suggesting that the response to pembrolizumab after dose-reduced cisplatin plus gemcitabine chemotherapy was inferior to that after carboplatin p...
Abstract null null Purpose null Muscle invasive bladder cancer surgical management has been historically a radical cystoprostatectomy in males and an anterior exenteration in females. Uterine, ovarian, and vaginal preservation are utilized, but raise concerns regarding risk to oncologic control, especially in variant histopathology or advanced stage. null null null Materials and Methods null A retrospective single institutional analysis identified radical cystectomies performed in women, includi...
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