Drug Delivery
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#1Xixi Li (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Shunyao Zhu (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
Last. Ting Zhang (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
view all 8 authors...
Melanoma is one of the most common malignant tumors. The anti-PD-1 antibody is used for the treatment of metastatic melanoma. Treatment success is only 35-40% and a range of immune-related adverse reactions can occur. Combination of anti-PD1 antibody therapy with other oncology therapies has been attempted. Herein, we assessed whether chlorogenic acid liposomes modified with sialic acid (CA-SAL) combined with anti-PD1 antibody treatment was efficacious as immunotherapy for melanoma. CA-SAL lipos...
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#1Jianhua Chen (Beijing University of Chinese Medicine)H-Index: 4
Last. Pengkai Ma (Beijing University of Chinese Medicine)H-Index: 4
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Sarcoma represents one of the most common malignant tumors with poor treatment outcomes and prognosis. Docetaxel (DTX) is acknowledged as one of the most important chemotherapy agents. The aim of this study was to improve the efficacy of docetaxel by incorporation into the mPEG-PLA nanoparticle (DTX NP) for the treatment of sarcoma. The DTX NP was prepared by emulsion solvent diffusion method and the prescription and preparation process were optimized through a single factor experiment. The opti...
1 CitationsSource
#1Rikkert Van Durme (UGent: Ghent University)H-Index: 2
#2Guillaume Crevecoeur (UGent: Ghent University)H-Index: 15
Last. Annelies CoeneH-Index: 10
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Magnetic drug targeting (MDT) is an application in the field of targeted drug delivery in which magnetic (nano)particles act as drug carriers. The particles can be steered toward specific regions i...
3 CitationsSource
#5Yongwei Gu (Fudan University)H-Index: 2
#6Jiyong Liu (Fudan University)H-Index: 4
Nanotechnology provides synthetic carriers for cancer drug delivery that protect cargos from degradation, control drug release and increase local accumulation at tumors. However, these non-natural vehicles display poor tumor targeting and potential toxicity and are eliminated by the immune system. Recently, biomimetic nanocarriers have been widely developed based on the concept of 'mimicking nature.' Among them, cell-derived biomimetic vehicles have become the focus of bionics research because o...
1 CitationsSource
#1Sara A. Abosabaa (British University in Egypt)H-Index: 1
#2Mona G. Arafa (British University in Egypt)H-Index: 7
Last. Aliaa Nabil ElMeshad (Cairo University)H-Index: 13
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The aim of this work is to exploit the advantages of chitosan (CS) as a nanocarrier for delivery of anti-cellulite drug, green tea extract (GTE), into subcutaneous adipose tissue. Primarily, analysis of herbal extract was conducted via newly developed and validated UPLC method. Ionic gelation method was adopted in the preparation of nanoparticles where the effect lecithin was investigated resulting in the formation of hybrid lipid-chitosan nanoparticles. Optimal formula showed a particle size of...
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In this work, series of pH-responsive hydrogels (FMA1-FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin (β-CD), chitosan (CS), methacrylic acid (MAA) and N' N'-methylenebis-acrylamide (MBA) were used to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy confirmed fabrication of new polymeric network, with successful incorpora...
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#1Yue Yu (MUST: Macau University of Science and Technology)
#2Zhou Wang (MUST: Macau University of Science and Technology)
Last. Yi-Zhun Zhu (MUST: Macau University of Science and Technology)H-Index: 58
view all 12 authors...
PURPOSE S-propargyl-cysteine (SPRC), an excellent endogenous hydrogen sulfide (H2S) donor, could elevate H2S levels via the cystathionine γ-lyase (CSE)/H2S pathway both in vitro and in vivo. However, the immediate release of H2S in vivo and daily administration of SPRC potentially limited its clinical use. METHODS To solve the fore-mentioned problem, in this study, the dendritic mesoporous silica nanoparticles (DMSN) was firstly prepared, and a sustained H2S delivery system consisted of SPRC and...
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#1Khaled M. Hosny (KAU: King Abdulaziz University)H-Index: 15
#2Waleed Y. Rizg (KAU: King Abdulaziz University)H-Index: 3
Last. Amani M. El Sisi (Beni-Suef University)H-Index: 5
view all 9 authors...
Natamycin (NT) is a synthetic broad-spectrum antifungal used in eye drops. However, it has low solubility and high molecular weight, limiting its permeation, and generally causes eye discomfort or irritation when administered. Therefore, the present study aimed to develop an ophthalmic in situ gel formulation with NT-loaded cubosomes to enhance ocular permeation, improve antifungal activity, and prolong the retention time within the eye. The NT-loaded cubosome (NT-Cub) formula was first optimize...
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#1Yifan Zhao (Qingdao University)
Last. Jie Cao (Qingdao University)H-Index: 17
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Phototherapy, with minimally invasive and cosmetic effect, has received considerable attention and been widely studied in cancer treatment, especially in biomaterials field. However, most nanomaterials applied for the delivery of phototherapy agents are usually recognized by the immune system or cleared by liver and kidney, thus hindering their clinical applications. To overcome these limitations, bionic technology stands out by virtue of its low antigenicity and targeting properties, including ...
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#1Dong Xu (Tianjin University of Traditional Chinese Medicine)H-Index: 4
#2Tao Qiao (Tianjin University of Traditional Chinese Medicine)
Last. Yuan-Lu Cui (Tianjin University of Traditional Chinese Medicine)H-Index: 20
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Depression is a primary public health problem. However, current antidepressants work slowly, and together with side effects. Herein, the alginate nanogels were constructed to load albiflorin (albiflorin nanogels), which further formed albiflorin nanogel loaded self-assembled thermosensitive hydrogel system (albiflorin-NGSTH) and were used to improve its antidepressant effects. The nanogel showed a nano-scaled particle size and stronger antioxidant activity. Rheological studies showed that albifl...
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