Pathology International
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#1Yutaka Hatanaka (Hokkaido University)H-Index: 23
#2Takeshi KuwataH-Index: 27
Last. Satoshi Fujii (YCU: Yokohama City University)H-Index: 22
view all 14 authors...
Clinical cancer genomic testing based on next-generation sequencing can help select genotype-matched therapy and provide diagnostic and prognostic information. Pathological tissue from malignant tumors obtained during routine practice are frequently used for genomic testing. This article is aimed to standardize the proper handling of pathological specimens in practice for genomic medicine based on the findings established in "Guidelines on the handling of pathological tissue samples for genomic ...
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#1Michiko Hino (Shiga University of Medical Science)
#2Shizuki TakemuraH-Index: 3
Last. Ryoji Kushima (Shiga University of Medical Science)H-Index: 45
view all 10 authors...
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#1Yu-Ju Su (Memorial Hospital of South Bend)
#2Yi-Hsuan Lee (NTU: National Taiwan University)
Last. Min-Shu Hsieh (NTU: National Taiwan University)
view all 3 authors...
SMARCB1(INI1)-deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. The classification of sinonasal adenocarcinoma (SNAC) is complex and yet to be redefined, especially the category of high-grade non-intestinal-type SNAC. Recently SMARCB1(INI1)-deficient SNACs with an unique oncocytoid/rhabdoid cytomorphology and variable degrees of glandular formation have been reported. Here we described a rare case of SMARCB1(INI1)-deficient SNAC composed of mainly...
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#1Ayami Ishida (Kyoto University)
#2Masakazu Fujimoto (Kyoto University)H-Index: 14
Last. Hironori Haga (Kyoto University)H-Index: 57
view all 8 authors...
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#1Yanjiao Hu (Qingdao University)
#2Guangqi Li (Qingdao University)H-Index: 2
Last. Ji-Gang Wang (Qingdao University)H-Index: 12
view all 6 authors...
The genetic alterations in the recurrent breast fibroepithelial tumors are poorly understood. In the present study, we aimed to investigate mediator protein complex subunit 12 (MED12) exon 2 and telomerase reverse transcriptase (TERT) promoter mutations in a series of primary and recurrent fibroepithelial tumors. Sanger sequencing for MED12 exon 2 and TERT promoter was performed in 26 pairs of primary and recurrent fibroepithelial tumors (19 pairs of phyllodes tumors and seven pairs of fibroaden...
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#1Aya Shinomiya (Kagawa University)H-Index: 8
#2Juanjuan Ye (Kagawa University)
Last. Takashi Tamiya (Kagawa University)H-Index: 40
view all 8 authors...
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#1Yuko Fukui (Okayama University)
#2Satoru Hayano (Okayama University)H-Index: 11
Last. Hiroshi Kamioka (Okayama University)H-Index: 29
view all 8 authors...
Diamond-Blackfan anemia (DBA) is a genetic disorder caused by mutations in genes encoding ribosomal proteins and characterized by erythroid aplasia and various physical abnormalities. Although accumulating evidence suggests that defective ribosome biogenesis leads to p53-mediated apoptosis in erythroid progenitor cells, little is known regarding the underlying causes of the physical abnormalities. In this study, we established induced pluripotent stem cells from a DBA patient with RPL5 haploinsu...
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#1Ayami Ishida (Kyoto University)
#2Yosuke Yamada (Kyoto University)H-Index: 25
Last. Hironori Haga (Kyoto University)H-Index: 57
view all 8 authors...
Even though it is a rare subtype, identifying the genetic features of thymic adenocarcinoma is valuable for a multifaceted understanding of thymic epithelial tumors. We experienced a female patient with thymic adenocarcinoma associated with thymic cysts. The tumor consisted of a solid whitish lesion (lesion-1) and a large cystic lesion with small papillary nodules (lesion-2). Microscopically, lesion-1 exhibited poorly differentiated adenocarcinoma accompanying numerous inflammatory cell infiltra...
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#1Fumio Ide (Meikai University)H-Index: 25
#2Yumi Ito (Tsurumi University)H-Index: 6
Last. Hidetaka Yamamoto (Kyushu University)H-Index: 43
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Inverted ductal papilloma (IDP) is one of the least common benign papillary/cystic neoplasms of the salivary duct system, being characterized histologically by florid hyperplasia of duct-type epithelial cells into a cystic lumen near the orifice with occasional endophytic growth of the surface squamous epithelium along the terminus of the affected excretory duct. Given its rarity, the exact etiology of IDP remains to be defined. We herein present the first evidence of oncogenic HRAS mutation in ...
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#1Long-Wei Lin (NTU: National Taiwan University)
#2Peng-Sheng Lai (NTU: National Taiwan University)
Last. Chung-Yu Chen (NTU: National Taiwan University)H-Index: 10
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It is unclear which prognostic factor such as pathological features and gene mutation are majorly relevant for stage III disease and whether they aid in determining patients who will be benefit from postoperative adjuvant chemotherapy. The expression of astrocyte-elevated gene-1 (AEG-1), thymidylate synthase (TS), excision repair cross-complementation group 1 (ERCC1), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor (VEGF) was examined to investigate their role in ...
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