Mechanisms of Ageing and Development
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#1Holly N. Wilkinson (Hull York Medical School)H-Index: 8
#2Matthew J. Hardman (Hull York Medical School)H-Index: 34
The skin is the body's primary defence against the external environment, preventing infection and desiccation. Therefore, alterations to skin homeostasis, for example with skin ageing, increase susceptibility to skin disease and injury. Skin biological ageing is uniquely influenced by a combination of intrinsic and extrinsic (primarily photoageing) factors, with differential effects on skin structure and function. Interestingly, skin architecture rapidly changes following the menopause, as a dir...
#1Virginia Boccardi (University of Perugia)H-Index: 22
#2Patrizia Mecocci (University of Perugia)H-Index: 96
Abstract null null The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and human studies. The role of cellular senescence in aging and the major age-related diseases -including Alzheimer's disease, atherosclerosis, and type 2 diabetes- as well as the use of senotherapeutic strategies in both experimental and preclinical studies, will be described. A large number of molecules, including synthetic a...
Abstract null null The capacity to regenerate damaged or lost tissue varies widely along the animal kingdom and generally declines with aging of the organism. The gradual accumulation of senescent cells in tissues during aging has been causally involved in their reduced function at old age, and to be at the basis of age-related diseases. Recently, however, cellular senescence has been shown to play a positive role as a morphogenetic force modelling and promoting tissue development during embryog...
#1Anna G.M. Rojer (VU: VU University Amsterdam)H-Index: 4
#2Keenan A. Ramsey (VU: VU University Amsterdam)H-Index: 3
Last. Andrea B. Maier (NUS: National University of Singapore)H-Index: 58
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Abstract null null Background null Both physical activity (PA) and sedentary behavior (SB) are important factors for healthy ageing. This systematic review aimed to determine the association of objectively assessed (instrumented) PA and SB with global cognitive function in older adults. null null null Methods null PubMed, Embase, the Cochrane Library (via Wiley), CINAHL, PsychINFO, and SPORTDiscus (via EBSCO) were searched from inception to June 21, 2020 for articles that described associations ...
#1V. Pils (BOKU: University of Natural Resources and Life Sciences, Vienna)H-Index: 2
#2Lucia Terlecki-Zaniewicz (BOKU: University of Natural Resources and Life Sciences, Vienna)H-Index: 6
Last. Ingo Lämmermann (BOKU: University of Natural Resources and Life Sciences, Vienna)H-Index: 5
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Abstract null null Lipid-based signalling modulates several cellular processes and intercellular communication during wound healing and tissue regeneration. Bioactive lipids include but are not limited to the diverse group of eicosanoids, phospholipids, and extracellular vesicles and mediate the attraction of immune cells, initiation of inflammatory responses, and their resolution. In aged individuals, wound healing and tissue regeneration are greatly impaired, resulting in a delayed healing pro...
#2Oliver Dreesen (Agency for Science, Technology and Research)H-Index: 21
The skin is comprised of different cell types with different proliferative capacities. Skin aging occurs with chronological age and upon exposure to extrinsic factors such as photodamage. During aging, senescent cells accumulate in different compartments of the human skin, leading to impaired skin physiology. Diverse skin cell types may respond differently to senescence-inducing stimuli and it is not clear how this results in aging-associated skin phenotypes and pathologies. This review aims to ...
#1Shubham Banga (Dal: Dalhousie University)H-Index: 3
#2Stefan Heinze-Milne (Dal: Dalhousie University)H-Index: 5
Last. Susan E. Howlett (Dal: Dalhousie University)H-Index: 44
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We investigated whether maladaptive, age-associated changes in heart structure and function were linked to circulating testosterone levels. Male C57BL/6 mice had a gonadectomy (GDX) or sham surgery at 4 weeks and effects of GDX on the heart were examined with echocardiography. Serum testosterone was measured with ELISA. Left ventricular (LV) mass increased with age but was smaller in GDX mice than sham at 18 months (144.0 ± 8.7 vs 118.2 ± 11.9 mg; p = 0.009). The isovolumic relaxation time (IVRT...
#1Maria De Luca (UAB: University of Alabama at Birmingham)H-Index: 15
#2Maurizio Mandalà (University of Calabria)H-Index: 17
Last. Giuseppina Rose (University of Calabria)H-Index: 33
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Abstract null null Adipose tissue (AT) is a complex organ, with multiple functions that are essential for maintaining metabolic health. A feature of AT is its capability to expand in response to physiological challenges, such as pregnancy and aging, and during chronic states of positive energy balance occurring throughout life. AT grows through adipogenesis and/or an increase in the size of existing adipocytes. One process that is required for healthy AT growth is the remodeling of the extracell...
#1Magdalena Dabrowska (Nencki Institute of Experimental Biology)H-Index: 7
#2Lukasz Uram (Rzeszów University of Technology)H-Index: 2
Last. Ewa Sikora (Nencki Institute of Experimental Biology)H-Index: 44
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Reversible cellular senescence was demonstrated previously to constitute colon cancer cell response to methotrexate. The current study presents a comparison of two senescent states of colon cancer cells, arrested and reversing, resulting from respectively, 120 h exposure to the drug, and 48 h exposure followed by 96 h regrowth in drug-free media. The upregulation of immunoproteasome subunit-coding genes and the increase in human leukocyte antigen HLA-A/B/C membrane level indicated MHC-I-restrict...
#1Monica Beatriz Frungieri (Instituto de Biología y Medicina Experimental)H-Index: 22
#2Ricardo S. Calandra (Instituto de Biología y Medicina Experimental)H-Index: 26
Last. Maria Eugenia Matzkin (Instituto de Biología y Medicina Experimental)H-Index: 7
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Ageing is linked to changes in the hypothalamic-pituitary-gonadal axis and a progressive decline in gonadal function. While women become infertile when they enter menopause, fertility decline in ageing men does not necessarily involve a complete cessation of spermatogenesis. Gonadal dysfunction in elderly people is characterized by morphological, endocrine and metabolic alterations affecting the reproductive function and quality of life. With advancing age, sexuality turns into a critical emotio...
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