Stem Cells
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Papers 5965
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#1Ramana Vaka (U of O: University of Ottawa)
#2Darryl R. Davis (U of O: University of Ottawa)H-Index: 22
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the "state-of-play" of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long-term ca...
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#1Abinaya Chandrasekaran (UCPH: University of Copenhagen)H-Index: 6
#2Pia Jensen (University of Southern Denmark)H-Index: 9
Last. Kristine K. Freude (UCPH: University of Copenhagen)H-Index: 19
view all 7 authors...
Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative and cognitive symptoms, affecting 1% of the population worldwide. The precise aetiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pa...
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#1Vincent P. Willard (Durham University)H-Index: 15
#2Holly A. Leddy (Duke University)H-Index: 24
Last. Farshid GuilakH-Index: 120
view all 6 authors...
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated with the process of chondrogenesis in adult stem cells as well as several cell lines. Here, we used a chondrogenic reporter (Col2a1-GFP) in murine induced pluripotent stem cells (iPSCs) to examine the hypothesis that TRPV4 serves as both a marker and a regul...
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#1Eva M. Rico-Leo (University of Extremadura)H-Index: 8
#2Luis Francisco Lorenzo-Martín (University of Salamanca)H-Index: 1
Last. Pedro M. Fernandez-Salguero (University of Extremadura)H-Index: 60
view all 6 authors...
Skin integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. While interfollicular epidermal progenitors control normal homeostasis, hair follicle stem cells residing within the bulge provide regenerative potential during hair cycle and in response to wounding. The aryl hydrocarbon receptor (AhR) modulates cell plasticity and differentiation and its overactivation results in severe skin lesions in humans. However, its physiological role in skin homeostas...
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#1Kim Olesen (University of Skövde)
#2Sergey Rodin (Uppsala University)H-Index: 18
Last. Karl-Henrik Grinnemo (Uppsala University)H-Index: 18
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Extracellular matrix (ECM) components govern a range of cell functions such as migration, proliferation, maintenance of stemness and differentiation. Cell niches that harbor stem-/progenitor cells, with matching ECM, have been shown in a range of organs, although their presence in the heart is still under debate. Determining niches depends on a range of in vitro and in vivo models and techniques, where animal models are powerful tools for studying cell-ECM dynamics, however, they are costly and ...
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#1Rongmei Qu (Southern Medical University)H-Index: 7
#2Kai He (Southern Medical University)
Last. Bing Sun (Southern Medical University)H-Index: 3
view all 15 authors...
Mesenchymal stem cells (MSCs) are known for their multilineage differentiation potential with immune-modulatory properties. The molecular underpinnings of differentiation remain largely undefined. In this study, we investigated the cellular and molecular features of chemically induced osteogenesis from MSC isolated from human adipose tissue (human adipose MSCs, hAMSCs) using single-cell RNA-sequencing (scRNA-seq). We found that a near complete differentiation of osteogenic clusters from hAMSCs u...
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#1Claudia ColussiH-Index: 22
#2Claudio Grassi (Agostino Gemelli University Polyclinic)H-Index: 40
Nucleoporins (Nups) are components of the nuclear pore complex that, besides regulating nucleus-cytoplasmic transport, emerged as a hub for chromatin interaction and gene expression modulation. Specifically, Nups act in a dynamic manner both at specific gene level and in the topological organization of chromatin domains. As such, they play a fundamental role during development and determination of stemness/differentiation balance in stem cells. An increasing number of reports indicate the implic...
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#1Margit Rosner (Medical University of Vienna)H-Index: 27
#2Markus Hengstschläger (Medical University of Vienna)H-Index: 42
Three-dimensional (3D) cell migration is an integral part of many physiologic processes. Although being well studied in the context of adult tissue homeostasis and cancer development, remarkably little is known about the invasive behavior of human stem cells. Using two different kinds of invasion assays, this study aimed at investigating and characterizing the 3D migratory capacity of human amniotic fluid stem cells (hAFSCs), a well-established fetal stem cell type. Eight hAFSC lines were found ...
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#1Yuan Dong (Capital Medical University)
#2Wei-Ning Kong (Capital Medical University)
Last. Wei An (Capital Medical University)H-Index: 5
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Cell-based therapeutic approaches have been proven to be effective strategies for the treatment of acute liver injury (ALI). However, widespread application of these procedures is limited by several key issues, including rapid loss of stemness in vitro, aberrant differentiation into undesirable cell types, and low engraftment in vivo. In this study, liver epithelial progenitor cells (LEPCs) were characterized and transfected with augmenter of liver regeneration (ALR). The results revealed that i...
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#1Xiaohuan Xia (UNMC: University of Nebraska Medical Center)H-Index: 6
#2Pooja Teotia (UNMC: University of Nebraska Medical Center)H-Index: 6
Last. Iqbal Ahmad (UNMC: University of Nebraska Medical Center)H-Index: 79
view all 5 authors...
Muller glia (MG), cells that maintain homeostasis in the retina, are dormant stem cells that can regenerate neurons upon injury. However, the regenerative property of MG, which is reproducibly displayed in the lower vertebrates, is not readily observed in the mammals even upon forced expression of regulatory genes or exposure to growth factors. Here, we demonstrate a reproducible unmasking of the neurogenic properties of enriched rodent MG by serial exposure to different combinations of small mo...
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Top fields of study
Molecular biology
Progenitor cell
Immunology
Stem cell
Biology
Cell biology