Contemporary Clinical Trials
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1.83
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Papers 2439
1 page of 244 pages (2,439 results)
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#1Jijia Wang (UTSW: University of Texas Southwestern Medical Center)
#2Jing Cao (SMU: Southern Methodist University)H-Index: 13
Last. Chul Ahn (UTSW: University of Texas Southwestern Medical Center)H-Index: 78
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Longitudinal cluster randomized trial (LCRT) and crossover cluster randomized trial (CCRT) are two variants of cluster randomized trials. In LCRTs, clusters of subjects are randomly assigned to different treatment groups and each subject has repeated measurements over the study period. In CCRTs, clusters of subjects are randomly assigned to different sequences. Within each sequence, clusters receive all treatments in a particular order. Both LCRTs and CCRTs lead to complicated correlation struct...
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#1John H. Krystal (Yale University)H-Index: 143
#2Bruce K. Chow (VA Palo Alto Healthcare System)H-Index: 19
Last. Lori L. Davis (UA: University of Alabama)H-Index: 50
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There are currently no validated pharmacotherapies for posttraumatic stress disorder (PTSD)-related insomnia. The purpose of the National Adaptive Trial for PTSD-Related Insomnia (NAP Study) is to efficiently compare to placebo the effects of three insomnia medications with different mechanisms of action that are already prescribed widely to veterans diagnosed with PTSD within U.S. Department of Veterans Affairs (VA) Medical Centers. This study plans to enroll 1224 patients from 34 VA Medical Ce...
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#1Allisandra G. Kummer (IU: Indiana University)
#2Mary Lynn Davis-Ajami (IU: Indiana University)H-Index: 6
Last. Wasantha Jayawardene (IU: Indiana University)H-Index: 11
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Abstract null null Background null Childhood obesity disproportionately affects rural communities where access to pediatric weight control services is limited. Telehealth may facilitate access to these services. null null null Objective null This paper describes the rationale, curriculum, and methodology for conducting a randomized controlled trial of a rural, family-based, telehealth intervention that aims to improve weight-related behaviors among children, compared to monthly newsletters. null...
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#1Hailey N. Miller (Duke University)H-Index: 2
#2Miriam B. Berger (Duke University)H-Index: 4
Last. Qing Yang (Duke University)H-Index: 10
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Abstract null null Introduction null Over 100 million adults in the United States have hypertension. The DASH (Dietary Approaches to Stop Hypertension) eating pattern is an evidence-based first-line treatment option for hypertension; however, adherence to the DASH eating pattern at a population level remains low. To address this gap, we will implement Nourish, a randomized controlled efficacy trial that will leverage a commercially-available smartphone application and evidence-based behavior cha...
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#1Annette R. Kaufman (NIH: National Institutes of Health)H-Index: 21
#2Joseph T. Ciccolo (NIH: National Institutes of Health)
Last. E. Jennifer Edelman (Yale University)H-Index: 23
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#1Eugene Friedman (Duke University)
#2John Franzone (Duke University)
Last. K. Linstrum (University of Pittsburgh)H-Index: 3
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Abstract null null While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the “PRONE” Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as de...
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#1Leonard H. Epstein (UB: University at Buffalo)H-Index: 121
#2Kenneth B. Schechtman (WashU: Washington University in St. Louis)H-Index: 79
Last. Nancy L. Geller (NIH: National Institutes of Health)H-Index: 81
view all 13 authors...
Family-based behavioral treatment (FBT) is an evidence-based treatment for pediatric obesity. FBT has primarily been implemented in specialty clinics, with highly trained interventionists. The goal of this study is to assess effectiveness of FBT implemented in pediatric primary care settings using newly trained interventionists who might implement FBT in pediatric practices. The goal is to randomize 528 families with a child with overweight/obesity (≥85th BMI percentile) and parent with overweig...
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#1Yixin Ren (MSD: Merck & Co.)H-Index: 1
#2Xiaoyun Li (MSD: Merck & Co.)
Last. Cong Chen (MSD: Merck & Co.)H-Index: 19
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Master protocols, in particular umbrella trials and platform trials, when evaluating multiple experimental treatments with a common control, could save patient resource, increase trial efficiency, and reduce drug development cost. Compared to the phase 3 platform trials that allow unlimited number of experimental arms to be added, it is more practical for individual companies to evaluate two experimental arms with a common control in an umbrella trial and allow the second experimental arm to be ...
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#1Jennifer S. Haas (Harvard University)H-Index: 156
#2Steven J. Atlas (Harvard University)H-Index: 57
Last. Tin H. Dang (Harvard University)
view all 23 authors...
Abstract null null Introduction null While substantial attention is focused on the delivery of routine preventive cancer screening, less attention has been paid to systematically ensuring that there is timely follow-up of abnormal screening test results. Barriers to completion of timely follow-up occur at the patient, provider, care team and system levels. null null null Methods null In this pragmatic cluster randomized controlled trial, primary care sites in three networks are randomized to one...
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#1Samuel L. Battalio (NU: Northwestern University)H-Index: 6
#2David E. Conroy (NU: Northwestern University)H-Index: 57
Last. Bonnie Spring (NU: Northwestern University)H-Index: 77
view all 10 authors...
BACKGROUND Relapse to smoking is commonly triggered by stress, but behavioral interventions have shown only modest efficacy in preventing stress-related relapse. Continuous digital sensing to detect states of smoking risk and intervention receptivity may make it feasible to increase treatment efficacy by adapting intervention timing. OBJECTIVE Aims are to investigate whether the delivery of a prompt to perform stress management behavior, as compared to no prompt, reduces the likelihood of (a) be...
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Top fields of study
Randomized controlled trial
Physical therapy
Psychological intervention
Intervention (counseling)
Clinical trial
Medicine