Molecular Endocrinology
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#1Shaihla A. Khan (UW: University of Wyoming)H-Index: 2
#2Brian S. Edwards (UW: University of Wyoming)H-Index: 6
Last. Amy M. Navratil (UW: University of Wyoming)H-Index: 8
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Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent fashion, but their role in the anterior pituitary gland is unknown. Thus, we investigated PAD expression and function in gonadotrope cells. The gonadotrope-derived LβT2 cell line strongly expresses PAD2 at the protein level compared with other PAD is...
9 CitationsSource
#1Takuyu Hashiguchi (NIH: National Institutes of Health)H-Index: 3
#2Shingo Arakawa (NIH: National Institutes of Health)H-Index: 2
Last. Masahiko Negishi (NIH: National Institutes of Health)H-Index: 64
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Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomimetic farnesoid X receptor (FXR) S154D mutant neither bound to nor trans-activated an FXR-response element-driven reporter gene and was rapidly degrad...
15 CitationsSource
#1Vini Nagaraj (Lund University)H-Index: 5
#2Abdulla S. Kazim (Lund University)H-Index: 2
Last. Erik Renström (Lund University)H-Index: 49
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Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes, but the mechanisms controlling basal insulin secretion remain unclear. Membrane rafts exist in pancreatic islet cells and spatially organize membrane ion channels and proteins controlling exocytosis, which may contribute to the regulation of insulin secretion. Membrane rafts (cholesterol and sphingolipid containing microdomains) were dramati...
10 CitationsSource
#1Patricia T. Jimenez (UTSW: University of Texas Southwestern Medical Center)H-Index: 10
#2Monica Mainigi (UPenn: University of Pennsylvania)H-Index: 16
Last. Carole R. Mendelson (UTSW: University of Texas Southwestern Medical Center)H-Index: 64
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For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. Here we demonstrate that the estradiol- and progesterone-regulated microRNA (miR)-200 family was markedly down-regulated in mouse endometrial stromal cells prior to implantation, whereas zinc finger E-box binding homeobox-1 and -2 and other known and p...
20 CitationsSource
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Endocrinology
Molecular biology
Receptor
Biochemistry
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Cell biology