Urologic Oncology-seminars and Original Investigations
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#1Timothy A. Masterson (IU: Indiana University)H-Index: 23
#2Scott T. Tagawa (Cornell University)H-Index: 53
Abstract null null Squamous cell carcinoma of the penis (SCCP) is uncommon in some countries (including the U.S.), but is an important malignancy elsewhere. As a rare disease, progress has been slow compared to more common tumor types discussed in this anniversary issue and most often limited to single-center or retrospective datasets. In this section we describe developments leading to the current standard approach with current research questions
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#1Andre Filipe Miranda (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Jeffrey M. Howard (UTSW: University of Texas Southwestern Medical Center)
Last. Yair Lotan (UTSW: University of Texas Southwestern Medical Center)H-Index: 107
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Abstract null null Purpose null Metastasis-directed radiation therapy (MDRT) may improve oncologic and quality of life outcomes in patients with metastatic cancer, but data on its use in metastatic bladder cancer is severely limited. We sought to review our institutional experience with MDRT in patients with metastatic bladder cancer following radical cystectomy. null null null Materials and Methods null We reviewed records of patients who underwent radical cystectomy and subsequent MDRT at our ...
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Abstract null null Over the past 25 years, diagnostic categories in genitourinary pathology have changed dramatically. Prostate cancer reporting incorporated numerous new variant categories, recognized the importance of intraductal carcinoma, and introduced the concept of Grade Groups. Pathologic diagnosis of bladder cancer not only added new variant categories, but also modified the grading of non-invasive urothelial neoplasms and refined staging definitions. Kidney cancer classification expand...
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#1Joseph M. Jacob (State University of New York Upstate Medical University)H-Index: 7
#2Andrea Necchi (Foundation Medicine)
Last. Jo-Anne Vergilio (Foundation Medicine)H-Index: 17
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Abstract null null Background null Carcinoma of the urethra (UrthCa) is an uncommon Genitourinary (GU) malignancy that can progress to advanced metastatic disease. null null null Methods null One hundred twenty-seven metastatic UrthCa underwent hybrid capture-based comprehensive genomic profiling to evaluate all classes of genomic alterations (GA). Tumor mutational burden was determined on up to 1.1 Mbp of sequenced DNA, and microsatellite instability was determined on 114 loci. PD-L1 expression...
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#1Shohei Nagakawa (Kyushu University)
#2Masaki Shiota (Kyushu University)H-Index: 36
Last. Junichi Inokuchi (Kyushu University)H-Index: 23
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Abstract null null Objective null Bacillus Calmette–Guerin (BCG) instillation therapy is widely used to reduce intravesical recurrence in non-muscle invasive bladder cancer (NMIBC). In this study, we aimed to reveal the genetic variations associated with intravesical recurrence after BCG therapy for NMIBC in a genome-wide association study (GWAS). null null null Materials and methods null This study included Japanese patients with NMIBC, in whom genomic DNA was obtained from whole blood samples....
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Abstract null null Background null Prostate cancer screening has reduced its mortality in 21%. However, this has also led to an increased number of biopsies in order to establish the diagnosis, many of them unnecessary. Current screening guidelines prioritize use of prostatic magnetic resonance and new biomarkers to reduce unnecessary biopsies, however, their implementation in developing countries screening programs is mainly limited by its costs. null null null Objective null We aimed to evalua...
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#1Daniel Roberson (UPenn: University of Pennsylvania)H-Index: 1
#2Raju R. Chelluri (UPenn: University of Pennsylvania)H-Index: 5
Last. Stephen J. Kovach (UPenn: University of Pennsylvania)H-Index: 34
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Abstract null null Introduction null Squamous cell carcinoma (SCC) and extramammary Paget's Disease (EMPD) of the scrotum are exceedingly rare. Given their propensity for local invasion and treatment with wide local excision, they can be highly morbid conditions. Outcomes of Mohs Micrographic Surgery (MMS) for scrotal cutaneous malignancy is not well described in current literature. We hypothesized that MMS for scrotal cutaneous malignancy would provide equivalent or improved oncologic outcomes ...
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#1Xin Li (SJTU: Shanghai Jiao Tong University)
#2Zhen Li (Tongji University)
Last. Weiming Wang (SJTU: Shanghai Jiao Tong University)H-Index: 19
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Abstract null null Objective null Serum uric acid (SUA) level is associated with the progression of chronic kidney disease (CKD). However, little is known about the predictive value of SUA variability for postoperative CKD in patients with renal cell carcinoma after radical nephrectomy. We aimed to investigate the association of SUA variability with postoperative CKD in this population. null null null Method null 85 patients with preoperative estimated glomerular filtration rate (eGFR)≥60 ml/min...
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#1Miss Michelle Christodoulidou (UCLH: University College Hospital)
#2Hussain M. Alnajjar (UCLH: University College Hospital)H-Index: 8
Last. Asif Muneer (UCLH: University College Hospital)H-Index: 24
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Abstract null null Introduction null We reviewed the medical and surgical management and long-term outcomes for patients diagnosed with penoscrotal extramammary Pagets disease (EMPD) within an eUROGEN centre. null null null Patients and Methods null Retrospective review of cases from an institutional database with biopsy proven penoscrotal EMPD. null null null Results null A total of 10 patients were identified with penoscrotal EMPD over a 10-year period. Two patients had a previous history of g...
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#1Mark D. Bevill (UI: University of Iowa)H-Index: 2
#2Victoria Troesch (Roy J. and Lucille A. Carver College of Medicine)
Last. Chad R. Tracy (UI: University of Iowa)H-Index: 19
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Abstract null null Introduction null We hypothesized that the number of cores needed to detect prostate cancer would decrease with increasing MRI-targeted biopsy (TBx) experience. null null null Methods null All patients undergoing TBx at our institution from May 2017 to August 2019 were enrolled in a prospectively maintained database. Five biopsy cores were obtained from each lesion ≥3 on PI-RADS v2.0 followed by a systematic 12-core biopsy. To assess learning curve, the study population was di...
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Bladder cancer
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