American Journal of Physiology-lung Cellular and Molecular Physiology
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#1Byron Thomashow (CUMC: Columbia University Medical Center)H-Index: 27
#2David M. Mannino (UK: University of Kentucky)H-Index: 104
Last. James D. CrapoH-Index: 112
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World COPD Day raises awareness about chronic obstructive pulmonary disease (COPD). The 2021 aim is to highlight the ongoing high burden of COPD in the midst on the COVID-19 pandemic.
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#1H. Sasaki (Tohoku University)H-Index: 20
#2Yi Zhang (Columbia University)H-Index: 17
Last. Kentaro Mizuta (Tohoku University)H-Index: 13
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Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracel...
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#1Dave Anuj Lagowala (Johns Hopkins University)
#2Seoyoung Kwon (Johns Hopkins University)
Last. Deok Ho Kim (Johns Hopkins University)H-Index: 54
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Human organ-on-a-chip models are powerful tools for pre-clinical research that can be used to study the mechanisms of disease and evaluate new targets for therapeutic intervention. Lung-on-a-chip models have been one of the most well-characterized designs in this field, and can be altered to evaluate various types of respiratory disease and to assess treatment candidates prior to clinical testing. These systems are capable of overcoming the flaws of conventional 2D cell culture and in vivo anima...
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#1Chujie Zhang (UR: University of Rochester)
#3Jessica LauH-Index: 2
Last. Robert Vassallo (UR: University of Rochester)H-Index: 40
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Epithelial-mesenchymal transition (EMT) creates an environment facilitating fibrosis following alveolar epithelial cell injury. IL-23 has important roles in chronic autoimmune conditions like rheumatoid arthritis (RA), but its role in the interstitial lung disease that affects RA patients is unclear. This study aimed to determine the pro-fibrogenic role of IL-23 on somatic alveolar type I (ATI) epithelial cells. Primary ATI cells were isolated from rats and cultured on plastic dishes for 1-3 wee...
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#1Larissa A. Shimoda (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 53
#2Chunxue Bai (Fudan University)H-Index: 55
Last. Rory E. Morty (University Hospital Heidelberg)H-Index: 52
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#1Sarah Panahabadi (University Hospital Bonn)
#2Katrin Heindel (Boston Children's Hospital)H-Index: 2
Last. Florian Kipfmueller (Boston Children's Hospital)H-Index: 4
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Invasive mechanical ventilation and oxygen toxicity are postnatal contributors to chronic lung disease of prematurity, also known as bronchopulmonary dysplasia (BPD). Cyfra 21-1 is a soluble fragment of cytokeratin 19, which belongs to the cytoskeleton stabilizing epithelial intermediate filaments. As a biomarker of structural integrity, Cyfra 21-1 might be associated with airway injury and lung hypoplasia in neonates. Serum Cyfra 21-1 concentrations for 80 preterm and 80 healthy term newborns w...
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#1Qianghu Tang (CQMU: Chongqing Medical University)H-Index: 5
#2Baijie Tu (CQMU: Chongqing Medical University)H-Index: 9
Last. Chengzhi Chen (CQMU: Chongqing Medical University)H-Index: 14
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Carbon black nanoparticles (CBNPs) are one of the most frequently used nanoparticles. Exposure to CBNPs during pregnancy (PrE to CBNPs) can directly induce inflammation, lung injury and genotoxicity in dams, and results in abnormalities in offspring. However, whether exposure to CBNPs during pregnancy enhances the susceptibility of offspring to environmental stimuli remains unknown. To address this issue, in this study, we intranasally treated pregnant mice with mock or CBNPs from gestational da...
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#1David M.G. Halpin (University of Exeter)
#2Claus VogelmeierH-Index: 70
Last. Alvar Agusti (University of Barcelona)H-Index: 117
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#1Evgenia Dobrinskikh (University of Colorado Denver)H-Index: 19
#2Saif I. Al-Juboori (University of Colorado Denver)H-Index: 3
Last. Clyde J. Wright (University of Colorado Denver)H-Index: 11
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Both pre-clinical and clinical studies have demonstrated that exposures to acetaminophen (APAP) at levels that cause hepatic injury cause pulmonary injury as well. However, whether exposures that d...
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#1Chao-Nan Zhang (Tianjin Medical University General Hospital)
#2Fanjian Li (Tianjin Medical University General Hospital)H-Index: 2
Last. Jianning Zhang (Tianjin Medical University General Hospital)H-Index: 28
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Acute lung injury (ALI), a common complication after traumatic brain injury (TBI), can evolve into acute respiratory distress syndrome (ARDS) and has a mortality rate of 30-40%. Secondary ALI after...
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