Biochimica et Biophysica Acta
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3.46
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#1Chisako Funada (AGU: Aoyama Gakuin University)
#2Nanami Tanino (AGU: Aoyama Gakuin University)
Last. Fumiyoshi Abe (AGU: Aoyama Gakuin University)H-Index: 27
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Abstract null null Living organisms are subject to various mechanical stressors, such as high hydrostatic pressure. Empirical evidence shows that under high pressure, the oxidative stress response is activated in Saccharomyces cerevisiae. However, the mechanisms involved in its antioxidant systems are unclear. Here, we demonstrate that superoxide dismutase 1 (Sod1) plays a role in resisting high pressure for cell growth. Mutants lacking Sod1 or Ccs1, the copper chaperone for Sod1, displayed grow...
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#1Erika Aloi (UNICAL: University of Calabria)H-Index: 3
#2Rosa Bartucci (UNICAL: University of Calabria)H-Index: 21
Abstract null null Continuous wave electron paramagnetic resonance spectroscopy of chain-labeled phospholipids is used to investigate the effects of hydration on the librational oscillations and the dynamical transition of phospholipid membranes in the low-temperature range 120–270 K. Bilayers of dipalmitoylphostatidiycholine (DPPC) spin-labeled at the first acyl chain segments and at the methyl ends and prepared at full, low, and very low hydration are considered. The segmental mean-square angu...
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#1Bosmat Refaeli (TAU: Tel Aviv University)H-Index: 5
#2Reuben Hiller (TAU: Tel Aviv University)H-Index: 15
Last. Daniel Khananshvili (TAU: Tel Aviv University)H-Index: 26
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Abstract null null The Na+/Ca2+ exchangers (NCXs) modulate the Ca2+ signaling and homeostasis in health and disease. null The transport cycle turnover rates (kcat) and the kcat/Km values of eukaryotic NCXs are ~104-times higher than those of prokaryotic NCXs. null Three ion-coordinating residues (out of twelve) differ between eukaryotic NCXs and NCX_Mj. null The replacement of three ion-coordinating residues in NCX_Mj does not increase kcat, probably due to the structural rigidity of NCX_Mj. Pho...
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#1Szymon Sekowski (UwB: University of Białystok)H-Index: 6
#2A. G. Veiko (Yanka Kupala State University of Grodno)H-Index: 3
Last. Nodira Abdulladjanova (UzAS: Academy of Sciences Republic of Uzbekistan)H-Index: 4
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Abstract null null Tannins belong to plant secondary metabolites exhibiting a wide range of biological activity. One of the important aspects of the realization of the biological effects of tannins is the interaction with lipids of cell membranes. In this work we studied the interaction of two hydrolysable tannins: 1,2,3,4,5-penta-O-galloyl-β- d -glucose (PGG) and 1,2-di-O-galloyl-4,6-valoneoyl-β- d -glucose (T1) which had the same number of both aromatic rings (5) and hydroxyl groups (15) but d...
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#1Chinnadurai Mani (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 8
#2Kaushlendra Tripathi (USA: University of South Alabama)H-Index: 13
Last. Komaraiah Palle (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 3
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Triple negative breast cancer (TNBC), an aggressive and highly metastatic subtype of breast cancer. Glioma-associated oncogene 1 (GLI1) is a transcription factor and effector of the Hedgehog (Hh) signaling pathway, and is predictive of poor survival for TNBC patients. A nanostring DNA Damage Response (DDR) mRNA panel was used to identify GLI1-induced regulation of DDR genes. Western blots, immunohistochemistry and immunofluorescence were used to evaluate protein expression. Colony assays and mam...
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#1Zheng Yao Low (Monash University)H-Index: 1
#2Ashley Jia Wen Yip (Monash University)H-Index: 1
Last. Sunil K. Lal (Monash University)H-Index: 32
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Ivermectin (IVM) is an FDA approved macrocyclic lactone compound traditionally used to treat parasitic infestations and has shown to have antiviral potential from previous in-vitro studies. Currently, IVM is commercially available as a veterinary drug but have also been applied in humans to treat onchocerciasis (river blindness - a parasitic worm infection) and strongyloidiasis (a roundworm/nematode infection). In light of the recent pandemic, the repurposing of IVM to combat SARS-CoV-2 has acqu...
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#1Nicolas Färber (University of Augsburg)
#2Christoph Westerhausen (University of Augsburg)H-Index: 11
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#1Ramin Zadali (IASBS: Institute for Advanced Studies in Basic Sciences)H-Index: 1
#2Vahid Hassani (IASBS: Institute for Advanced Studies in Basic Sciences)H-Index: 1
Last. Mohsen Nemat-Gorgani (SU: Stanford University)H-Index: 24
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Alpha-synuclein (α-syn) aggregation and mitochondrial dysfunction are considered as two of the main factors associated with Parkinson's disease (PD). In the present investigation, the effectiveness of the amyloid fibrils obtained from α-syn with those of hen egg white lysozyme (HEWL), as disease-related and-unrelated proteins, to damage rat brain and rat liver mitochondria have been investigated. This was extended by looking at SH-SY5Y human neuroblastoma cells and erythrocytes, thereby investig...
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#1Weihua Qiu (VCU: Virginia Commonwealth University)H-Index: 2
#2Youzhong Guo (VCU: Virginia Commonwealth University)H-Index: 2
Abstract null null Mycobacterial membrane protein large 3 (Mmpl3) as a trehalose monomycolate lipid transporter contributes to cell wall biosynthesis. Inhibition of Mmpl3 can suppress cell growth and lead to mycobacterial death. SQ109 is a hydrophobic inhibitor of Mmpl3. We have devised a detergent-free strategy to characterize the SQ109/Mmpl3 interaction using the Native Cell Membrane Nanoparticles (NCMN) system, a new method for extracting membrane proteins that better retains native lipids. T...
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#1Alain Bolaño Alvarez (UNC: National University of Córdoba)H-Index: 1
Last. Gerardo D. Fidelio (UNC: National University of Córdoba)H-Index: 32
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Abstract null null Gangliosides induced a smelting process in nanostructured amyloid fibril-like films throughout the surface properties contributed by glycosphingolipids when mixed with 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC)/Aβ(1–40) amyloid peptide. We observed a dynamical smelting process when pre-formed amyloid/phospholipid mixture is laterally mixed with gangliosides. This particular environment, gangliosides/phospholipid/Aβ(1–40) peptide mixed interfaces, showed complex miscibilit...
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