Toxicology in Vitro
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#1Grzegorz Bartosz (UPRRP College of Natural Sciences)H-Index: 58
#2Natalia Pieńkowska (UPRRP College of Natural Sciences)H-Index: 4
Last. Izabela Sadowska-Bartosz (UPRRP College of Natural Sciences)H-Index: 20
view all 3 authors...
It has been argued that the mol/cell metric is more universal than concentration of the toxic agent since in many cases the effect of dose expressed as mol/cell is independent of ex-perimental setup. We confirmed it for hemolysis of erythrocytes in phosphate-buffered saline induced by hypochlorite where the amount of femtomoles/cell of hypochlorite needed for 50% hemolysis was independent of erythrocyte concentration. However, in the presence of blood plasma this metric became dependent on cell ...
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#1A Juarez Facio (UNICAEN: Université de Caen Normandie)
#2Jérôme Yon (CNRS: French National Centre for Scientific Research)H-Index: 20
Last. Laurence Chevalier (CNRS: French National Centre for Scientific Research)H-Index: 3
view all 12 authors...
Abstract null null Air pollution has significant health effects worldwide, and airborne particles play a significant role in these effects. Ultrafine particles (UFPs) have an aerodynamic diameter of 0.1 μm or less, can penetrate deep into the respiratory tree, and are more toxic due to their large specific surface area, which should adsorb organic compounds. The aim of this study is to show the toxicological effects of UFPs with high organic content at low dose on BEAS-2B cells through at air-li...
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#1Li Zhang (SEU: Southeast University)H-Index: 1
#2Shichen XuH-Index: 8
Last. Hui-Xin YuH-Index: 13
view all 9 authors...
Curcumin, a polyphenolic compound, is a well-known anticancer agent, although its poor bioavailability remains a big concern. Recent studies suggest that autophagy-targeted therapy may be a useful adjunct treatment for patients with thyroid cancer. Curcumin acts as an autophagy inducer on many cancer cells. However, little is known about the exact role of curcumin on thyroid cancer cells. In the present study, curcumin significantly inhibited the growth of thyroid cancer cells. Autophagy was mar...
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#1Nandita SaxenaH-Index: 4
#2Pooja PhatakH-Index: 1
Last. Vinita ChauhanH-Index: 16
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Abstract null null Abrus precatorius is a highly toxic seed containing the poison abrin. Similar in properties to ricin, this toxin binds to ribosomes causing cessation of protein synthesis and cell death. With an estimated human lethal dose of 0.1–1 μg/kg, it has been the cause of fatalities due to accidental and intentional ingestion. In present study, we profiled seven human cell lines of different organ origin, for their sensitivity against abrin toxicity. These cell lines are, A549, COLO 20...
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#1D.V. OkhrimenkoH-Index: 1
#2J.A. BøtnerH-Index: 1
Last. M. SolvangH-Index: 1
view all 6 authors...
Abstract null null The biopersistence of fiber materials is one of the cornerstones in estimating potential risk to human health upon inhalation. To connect epidemiological and in vivo investigations with in vitro studies, reliable and robust methods of fiber biopersistence determination and understanding of fiber dissolution mechanism are required. We investigated dissolution properties of oil treated stone wool fibers with and without sugar-based binder (SBB) at 37 °C in the liquids representi...
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#1Thomas W. Sawyer (DRDC: Defence Research and Development Canada)H-Index: 14
#2Yushan Wang (DRDC: Defence Research and Development Canada)H-Index: 12
Last. Grant Hennes (DRDC: Defence Research and Development Canada)H-Index: 3
view all 5 authors...
The contact poison VX (O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate) is a chemical warfare agent that is one of the most toxic organophosphorus compounds known. Its primary mechanism of toxic action is through the inhibition of acetylcholinesterase and resultant respiratory paralysis. The majority of work on VX has thus concentrated on its potent anticholinesterase activity and acute toxicity, with few studies investigating potential long-term effects. In this report we describe th...
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#1Pégah JaliliH-Index: 5
#2Sylvie HuetH-Index: 9
Last. Peter LauxH-Index: 23
view all 13 authors...
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#1Stacey Herriage (OSU: Oklahoma State University)
#2Guangping Chen (OSU: Oklahoma State University)H-Index: 13
Last. Carey Pope (OSU: Oklahoma State University)H-Index: 99
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Abstract null null Chlorpyrifos oxon (CPO) is the active metabolite of the organophosphorus pesticide, chlorpyrifos. CPO is a potent inhibitor of acetylcholinesterase (AChE) and other serine hydrolases including fatty acid amide hydrolase (FAAH). AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide,...
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#1Luciana Madureira de Araujo Lowndes Viera (FIOCRUZ: Oswaldo Cruz Foundation)
#2Ronald Santos Silva (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 6
Last. Maria Helena Simões Villas Bôas (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
view all 5 authors...
Abstract null null The Hen's Egg Test – Chorioallantoic Membrane (HET-CAM) is a valid alternative method used to assess the potential for eye irritation from chemicals. This method is the only one that mimics the conjunctivae of the eye and aims to semi-quantitatively evaluate the irritant potential of a chemical on the chorioallantoic membrane surrounding the chicken embryo in egg by observing the irritation effects on the membrane immediately after the pure or diluted chemical is applied. The ...
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#1Carlos Angelé-Martínez (Clemson University)H-Index: 3
#2Fathima S. Ameer (Clemson University)H-Index: 8
Last. Julia L. Brumaghim (Clemson University)H-Index: 28
view all 7 authors...
Abstract null null The ability of ten polyphenolic antioxidants to prevent CuO nanoparticle (NPCuO) and H2O2-mediated DNA damage and cytotoxicity was investigated. Five of the polyphenols (MEPCA, PREGA, MEGA, ECG, and EGCG) prevent NPCuO/H2O2-mediated DNA damage (IC50 values of 7.5–800 μM), three have no effect (PCA, VA, and EC), and two (GA and EGC) result in increased DNA damage. Most polyphenols had similar antioxidant/prooxidant activity in the presence of NPCuO or free copper ions. Electron...
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