Disease Markers
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#1Lin Fu (WMC: Wenzhou Medical University)H-Index: 7
Last. Yufeng Ye
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Objectives. To investigate the classification performance of support vector machine in mild traumatic brain injury (mTBI) from normal controls. Methods. Twenty-four mTBI patients (15 males and 9 females; mean age, null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null null years) and 24 age and sex-matched normal controls (13 males and 11 females; mean ...
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#1Li Wang (CAS: Chinese Academy of Sciences)H-Index: 3
#2Wenjun Zhang (CQU: Chongqing University)H-Index: 3
Last. Jiaxi Lu (CAS: Chinese Academy of Sciences)
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Background. With the development of sequencing technology, several signatures have been reported for the prediction of prognosis in patients with hepatocellular carcinoma (HCC). However, the above signatures are characterized by cumbersome application. Therefore, the study is aimed at screening out a robust stratification system based on only one gene to guide treatment. Methods. Firstly, we used the limma package for performing differential expression analysis on 374 HCC samples, followed by Co...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA virus first identified in December 2019 in Wuhan, China, and responsible for coronavirus disease 2019 (COVID-19). The ongoing COVID-19 pandemic is impacting healthcare worldwide. Patients who develop coagulopathy have worse outcomes. The pathophysiology of COVID-19 suggests a strong interplay between hemostasis and immune cells, especially neutrophils. Our purpose was to assess neutrophil fluorescence as a poten...
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Objectives. Most patients with systemic lupus erythematosus (SLE) develop lupus nephritis (LN) with severe kidney manifestations. Renal fibrosis can be primarily attributed to overproliferation of mesangial cells (MCs), which are subject to drug treatment. Nevertheless, the detailed mechanisms remain elusive. We sought to identify the effect of cyclophosphamide (CTX), a drug commonly used for LN treatment, on MC proliferation and explore its underlying mechanisms. Material/Methods. Cell prolifer...
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#1Iason Psilopatis (National and Kapodistrian University of Athens)
#2Alexandros Pergaris (National and Kapodistrian University of Athens)H-Index: 2
Last. Stamatios Theocharis (National and Kapodistrian University of Athens)H-Index: 51
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Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Epigenetic alterations are implicated in endometrial cancer development and progression. Histone deacetylase inhibitors are a novel class of anticancer drugs that increase the level of histone acetylation in many cell types, thereby inducing cell cycle arrest, differentiation, and apoptotic cell death. This review is aimed at determining the role of histone acetylation and examining the the...
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#1Feng Qiu (HMU: Harbin Medical University)
#2Yumei Zhu (HMU: Harbin Medical University)
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#2Shilong Sun (CJFH: China-Japan Friendship Hospital)
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#1Peiwen Zhu (Fudan University)
#2Qian Yang (Fudan University)
Last. Qing Chang (Fudan University)
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Retinitis pigmentosa (RP) is a major cause of blindness that is difficult to diagnose and treat. PKM2, a subtype of pyruvate kinase, is strongly associated with oxidative stress and is expressed in photoreceptors. We investigated whether PKM2 reduces photoreceptor cell apoptosis and evaluated possible antiapoptotic mechanisms in RP. We established RP models by exposing 661W cells to blue light and modulated PKM2 activity using a PKM2 inhibitor. We measured the apoptosis rates using calcein-aceto...
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The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of research, more and more evidence showed that mtDNA is related to the occurrence and development of CVD. Current studies mainly focus on how mtDNA copy number, an indirect biomarker of mitochondrial fun...
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