Journal of Endocrinology
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#1Jordan E. Hamden (UBC: University of British Columbia)H-Index: 4
#2Melody Salehzadeh (UBC: University of British Columbia)H-Index: 1
Last. Kiran K. Soma (UBC: University of British Columbia)H-Index: 54
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Glucocorticoids (GCs) are secreted by the adrenal glands and locally produced by lymphoid organs. Adrenal GC secretion at baseline and in response to stressors is greatly reduced during the stress hyporesponsive period (SHRP) in neonatal mice (postnatal day (PND) 2-12). It is unknown whether lymphoid GC production increases in response to stressors during the SHRP. Here, we administered an acute stressor (isoflurane anesthesia) to mice before, during, and after the SHRP and measured systemic and...
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#1Katie L. Davies (University of Cambridge)H-Index: 3
#2Emily J. Camm (Hudson Institute of Medical Research)H-Index: 21
Last. AL Fowden (University of Cambridge)H-Index: 8
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In adults, glucocorticoids act to match the supply and demand for energy during physiological challenges, partly through actions on tissue mitochondrial oxidative phosphorylation (OXPHOS) capacity. However, little is known about the role of the natural prepartum rise in fetal glucocorticoid concentrations in preparing tissues for the increased postnatal energy demands. This study examined the effect of manipulating cortisol concentrations in fetal sheep during late gestation on mitochondrial OXP...
#1Isao Tamura (Yamaguchi University)H-Index: 20
#2Hiroshi Tamura (Yamaguchi University)H-Index: 39
Last. Shun Sato (Yamaguchi University)H-Index: 19
view all 11 authors...
Women usually experience body weight gain with aging, which can put them at risk for many chronic diseases. Previous studies indicated that melatonin treatment attenuates body weight gain and abdominal fat deposition in several male animals. However, it is unclear whether melatonin affects female animals in the same way. This study investigated whether long-term melatonin treatment can attenuate body weight gain with aging and, if it does, what the mechanism is. Ten-week-old female ICR mice were...
#1Antonio Gázquez (University of Murcia)H-Index: 7
#2Francisca Rodriguez (University of Murcia)H-Index: 15
Last. Elvira Larqué (University of Murcia)H-Index: 28
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Gestational diabetes mellitus (GDM) reduces maternal adiponectin and docosahexaenoic acid (DHA) materno-fetal transfer, which may have negative consequences for the offspring. Our aim was to evaluate the effects of administration of a novel adiponectin agonist (AdipoRon) to GDM rats on the long-term consequences in glycaemia and fatty acids (FA) profile in the offspring. Pregnant rats were randomized to three groups: GDM rats (GDM, n=8), GDM rats treated with AdipoRon (GDM+ADI, n=9) and control ...
#1Hye Jin Lee (KU: Korea University)H-Index: 52
#2Haifei Shi (Miami University)H-Index: 15
Last. Dong Hoon Kim (KU: Korea University)H-Index: 17
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Vascular reactivity of adipose tissue (AT) is hypothesized to play an important role in the development of obesity. However, the exact role of vascular reactivity in the development of obesity remains unclear. In this study, we investigated the chronological changes in vascular reactivity and the microenvironments of the visceral AT (VAT) and subcutaneous AT (SAT) in lean and obese mice. Changes in blood flow levels induced by a β-adrenoceptor agonist (isoproterenol) were significantly lower in ...
#1Nattayaporn Apaijai (CMU: Chiang Mai University)H-Index: 16
#2Kewarin Jinawong (CMU: Chiang Mai University)H-Index: 1
Last. Nipon Chattipakorn (CMU: Chiang Mai University)H-Index: 56
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High fat diet (HFD) consumption induces prediabetes and left ventricular dysfunction through many pathways including the cell death pathway, necroptosis. Although benefits of necroptosis inhibitor (necrostatin-1 or Nec-1) in the brain of prediabetic rats have been shown, the effects of Nec-1 on cardiac autonomic function, blood pressure, and cardiac function, and the mechanisms involved have not been investigated. Male Wistar rats were fed with either a normal diet (n=8) or HFD (n=24) for 12 wee...
#1Simon Travers (Université Paris-Saclay)H-Index: 6
#2Laetitia MartinerieH-Index: 12
Last. Eric Pussard (Université Paris-Saclay)
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Preterm birth is associated with immaturity of several crucial physiological functions notably those prevailing in the lung and kidney. Recently, a steroid secretion deficiency was identified in very preterm neonates, associated with a partial yet transient deficiency in 11β-hydroxylase activity, sustaining cortisol synthesis. However, the P450c11β enzyme is expressed in preterm adrenal glands, we hypothesized an inhibition of cortisol production by adrenomedullin (ADM), a peptide highly produce...
#1Ida Marie BoisenH-Index: 4
#2John E. Nielsen (Nielsen Holdings N.V.)
Last. Geert Carmeliet (Katholieke Universiteit Leuven)H-Index: 68
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Vitamin D is important for gonadal function in rodents, and improvement of vitamin D status in men with low sperm counts increases live birth rate. Vitamin D is a regulator of transcellular calcium transport in the intestine and kidney and may influence the dramatic changes in the luminal calcium concentration in epididymis. Here, we show spatial expression in the male reproductive tract of vitamin D receptor (VDR)-regulated factors involved in calcium transport: Transient receptor potential van...
#1Marta Lantero Rodriguez (University of Gothenburg)H-Index: 2
#2Maaike Schilperoort (LUMC: Leiden University Medical Center)H-Index: 6
Last. Jan Borén (University of Gothenburg)H-Index: 90
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Brown adipose tissue (BAT) burns substantial amounts of mainly lipids to produce heat. Some studies indicate that BAT activity and core body temperature are lower in males than females. Here we investigated the role of testosterone and its receptor (the androgen receptor; AR) in metabolic BAT activity in male mice. Castration, which renders mice testosterone deficient, slightly promoted the expression of thermogenic markers in BAT, decreased BAT lipid content, and increased basal lipolysis in is...
#1Yu Zhou (Nanjing Medical University)H-Index: 3
#2Min Gong (Nanjing Medical University)H-Index: 1
Last. Rong Ju (Nanjing Medical University)H-Index: 3
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Prenatal androgen exposure induces metabolic disorders in female offspring. However, the long-term effect of maternal testosterone excess on glucose metabolism, especially on pancreatic beta cell function, is rarely investigated. Our current study mainly focused on the effects of prenatal testosterone exposure on glucose metabolism and pancreatic beta cell function in aged female offspring. By using maternal mice and their female offspring as animal models, we found that prenatal androgen treatm...
Top fields of study
Diabetes mellitus