Current Medicinal Chemistry
Papers 6,616
1 page of 662 pages (6,616 results)
#1Anastasios I. Birmpilis (UoA: National and Kapodistrian University of Athens)H-Index: 2
#2Panagiotis Vitsos (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last. Wolfgang Voelter (University of Tübingen)H-Index: 63
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Background null Members of the α-thymosin family have long been studied for their immunostimulating properties. Among them, the danger-associated molecular patterns (DAMPs) prothymosin α (proTα) and its C-terminal decapeptide proTα(100-109) have been shown to act as immunomodulators in vitro, due to their ability to promote T helper type 1 (Th1) responses. Recently, we verified these findings in vivo, showing that both proTα and proTα(100-109) enhance antitumor-reactive T cell-mediated responses...
#1Lucia M. BalsaH-Index: 5
#2Enrique J. BaranH-Index: 33
Last. Ignacio E. LeónH-Index: 17
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Copper is an essential element for most aerobic organisms, with an important function as a structural and catalytic cofactor, and in consequence, it is implicated in several biological actions. The relevant aspects of chemistry and biochemistry and the importance of copper compounds in medicine give us a comprehensive knowledge of the multifaceted applications of copper in physiology and physiopathology. In this review, we present an outline of the chemistry and the antitumor properties of coppe...
#1Shigao Huang (Fourth Military Medical University)
#2Qi Zhao (Fourth Military Medical University)
#1Adeleh SahebnasaghH-Index: 7
#2Razieh Avan (Birjand University of Medical Sciences)H-Index: 5
Last. Fatemeh Saghafi (Shahid Sadoughi University of Medical Sciences and Health Services)H-Index: 5
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In this review, we discussed the biological targets of carnitine, its effects on immune function, and how L-carnitine supplementation may help critically ill patients. L-carnitine is a potent antioxidant. L-carnitine depletion has been observed in prolonged intensive care unit (ICU) stays, while L-carnitine supplementation has beneficial effects in health promotion and regulation of immunity. It is essential for the uptake of fatty acids into mitochondria. By inhibiting the ubiquitin-proteasome ...
#1Alemeh Mohammadzadeh (University of Tabriz)H-Index: 1
#2Narges Dastmalchi (University of Tabriz)H-Index: 7
Last. Reza Safaralizadeh (University of Tabriz)H-Index: 19
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As a novel group of non-coding RNAs, long non-coding RNA (lncRNAs) can substantially regulate various biological processes. Downregulated tumor-suppressive lncRNAs and upregulated oncogenic lncRNAs (onco-lncRNAs) have been implicated in gastric cancer (GC) development. These dysregulations have been associated with decreased chemosensitivity, inhibited apoptosis, and increased tumor migration in GC. Besides, growing evidence indicates that lncRNAs can be a valuable diagnostic and prognostic biom...
Initially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and...
#1Christoph Müller (LMU: Ludwig Maximilian University of Munich)H-Index: 14
#2Emily Hank (LMU: Ludwig Maximilian University of Munich)
Last. Franz Bracher (LMU: Ludwig Maximilian University of Munich)H-Index: 33
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During the last decade, the understanding of the biological functions of cholesterol biosynthesis intermediates has changed significantly. Particularly, the enzyme sterol dehydrocholesterol reductase 24 (DHCR24) has taken center stage as a potential drug target. Inhibition of DHCR24 leads to accumulation of the endogenous, biologically active metabolite cholesta-5,24-dien-3β-ol (desmosterol). Desmosterol is an endogenous agonist of the liver X receptor (LXR). LXR is a master regulator of lipid m...
#1Francesca Seghetti (UNIBO: University of Bologna)H-Index: 7
#2Silvia Gobbi (UNIBO: University of Bologna)H-Index: 20
Last. Alessandra Bisi (UNIBO: University of Bologna)H-Index: 29
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Pharmacological treatment of complex pathologies such as neurodegenerative diseases still represents a major challenge, due to the networked pathways involved in their onset and progression that may require equally complex therapeutic approaches. Polypharmacology, based on the simultaneous modulation of multiple targets involved in the disease, may offer the potential to increase effectiveness and reduce the drawbacks related to the use of drug combinations. Clearly, this approach requires both ...
#1Alessandra Della Vecchia (UniPi: University of Pisa)H-Index: 5
#2Alessandro Arone (UniPi: University of Pisa)H-Index: 1
Last. Donatella Marazziti (UniPi: University of Pisa)H-Index: 58
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Background null The pathophysiology of major depressive disorder (MDD), one of the major causes of worldwide disability, is still largely unclear, despite the increasing data reporting evidence of multiple alterations of different systems. Recently, there was a renewed interest in the signalling of gamma aminobutyric acid (GABA) - the main inhibitory neurotransmitter. null Objective null The aim of this study was to review and comment on the available literature about the involvement of GABA in ...
#1Kazuhiro Haraguchi (Nihon Pharmaceutical University)H-Index: 17
#2Hiroki Kumamoto (Nihon Pharmaceutical University)H-Index: 2
Last. Hiromichi Tanaka (Showa University)H-Index: 33
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The first highly diastereoselective synthesis of -anomers of 4'-thionucleosides has been carried out by means of electrophilic glycosidation utilizing 3,5-O-(di-t-butylsilylene) (DTBS)-4-thiofuranoid glycal as a glycosyl donor. The resulting glycosides were transformed into ribo-, 2'-deoxy- and arabinofuranosyl nucleosides through a chemical transformation of the 2'-substituent. The additive Pummerer reaction of the glycal S-oxide gave 1,2-di-O-acetyl-3,5-O-DTBS-4-thioribofuranose. The utility ...
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