Biotechnology Journal
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Papers 2831
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#1Philipp Schneider (MPG: Max Planck Society)H-Index: 3
#2Radhakrishnan Mahadevan (U of T: University of Toronto)H-Index: 45
Last. Steffen Klamt (MPG: Max Planck Society)H-Index: 43
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BACKGROUND A widely used design principle for metabolic engineering of microorganisms aims to introduce interventions that enforce growth-coupled product synthesis such that the product of interest becomes a (mandatory) by-product of growth. However, different variants and partially contradicting notions of growth-coupled production (GCP) exist. METHODS AND RESULTS Herein, we propose an ontology for the different degrees of GCP and clarify their relationships. Ordered by coupling degree, we dist...
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#1Jeroen Vereman (Katholieke Universiteit Leuven)
#2Tim Thysens (Katholieke Universiteit Leuven)
Last. Ilse Van De Voorde (Katholieke Universiteit Leuven)H-Index: 7
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Hydrophobins (HFBs) are a group of highly functional, low molecular weight proteins with the ability to self-assemble at hydrophobic-hydrophilic interfaces. The surface active, cysteine-rich proteins are found in filamentous fungi such as Trichoderma reesei. In the present study multiple extraction solvents and conditions were screened for the mycelium bound hydrophobin HFBI and the effects on the total amount of extracted proteins, HFBI recovery and HFBI gushing activity were investigated to ga...
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#1S. Swetha (SRM University)H-Index: 1
#1Sampath Swetha (SRM University)
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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BACKGROUND Treatment of critical-sized bone defects has progressively evolved over the years from metallic implants to more ingenious three-dimensional-based scaffolds. The use of three-dimensional scaffolds for bone regeneration from biodegradable polymers like poly(lactic acid) (PLA) is gaining popularity. Scaffolds with surface functionalization using gelatin (Gel) have the advantages of biocompatibility and cell adhesion. Nano-hydroxyapatite (nHAp) is one of the most promising implant materi...
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#1Nurzhan Kuanyshev (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
#2Anshu Deewan (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last. Yong Su Jin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 52
view all 9 authors...
Simultaneous co-fermentation of glucose and xylose is a key desired trait of engineered Saccharomyces cerevisiae for efficient and rapid production of biofuels and chemicals. However, glucose strongly inhibits xylose transport by endogenous hexose transporters of S. cerevisiae. We identified structurally distant sugar transporters (Lipomyces starkeyi LST1_205437 and Arabidopsis thaliana AtSWEET7) capable of co-transporting glucose and xylose from previously unexplored oleaginous yeasts and plant...
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#1Kingsley Wong (UW: University of Waterloo)H-Index: 2
#2Juewen Liu (UW: University of Waterloo)H-Index: 87
DNA oligonucleotides are widely used in a diverse range of research fields from analytical chemistry, molecular biology, nanotechnology to drug delivery. In these applications, DNA hybridization is often the most important enabling reaction. Achieving control over hybridization kinetics and a high yield of hybridized products is needed to ensure high-quality and reproducible results. Since DNA strands are highly negatively charged and can also fold upon itself to form various intramolecular stru...
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#1Xuelian Qi (Nanjing Tech University)
#2Shao J (Nanjing Tech University)
Last. Ming Yan (Nanjing Tech University)H-Index: 15
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Background null 2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is an important derivative of L-ascorbic acid (L-AA), which has the distinct advantages of non-reducibility, antioxidation, and reproducible decomposition into L-AA and glucose. Enzymatic synthesis is a preferred method for AA-2G production over alternative chemical synthesis owing to the regioselective glycosylation reaction. α-Glucosidase, an enzyme classed into O-glycoside hydrolases, might be used in glycosylation reactions to sy...
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#1Wan-Ying Chu (ZSTU: Zhejiang Sci-Tech University)
#2Ke Jiang (ZSTU: Zhejiang Sci-Tech University)
Last. Shenghou Wang (SYNU: Shenyang Normal University)
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BACKGROUND Biogenic 2,3-butanediol (2,3-BDO) is a high-value-added compound that can be used as a liquid fuel and a platform chemical. Bioproduction of 2,3-BDO is an environmentally friendly choice. METHOD AND RESULTS Three recombinant derivatives of the novel Klebsiella sp. isolate FSoil 024 (WT) were constructed via different strategies including deletion of lactate dehydrogenase by λ-Red homologous recombination technology, overexpression of the small-noncoding RNA RyhB and a combination of b...
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BACKGROUND Understanding the pathophysiology of degenerative diseases pertaining to nervous system, ocular region, bone/cartilage and muscle are still being comprehended, thus delaying the availability of targeted therapies. PURPOSE AND SCOPE Newer micro-physiological systems (organ-on-chip technology) involves development of more sophisticated devices, modelling a range of in vitro human tissues and an array of models for diseased conditions. These models expand opportunities for high throughpu...
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#1Mohammad Karim Khaleghi (TMU: Tarbiat Modares University)
#2Iman Shahidi Pour Savizi (TMU: Tarbiat Modares University)H-Index: 1
Last. Seyed Abbas Shojaosadati (TMU: Tarbiat Modares University)H-Index: 37
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Recent noteworthy advances in developing high-performing microbial and mammalian strains have enabled the sustainable production of bio-economically valuable substances such as bio-compounds, biofuels, and biopharmaceuticals. However, to obtain an industrially viable mass-production scheme, much time and effort are required. The robust and rational design of fermentation processes requires analysis and optimization of different extracellular conditions and medium components, which have a massive...
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#1Nam Kyu Kang (UIUC: University of Illinois at Urbana–Champaign)H-Index: 12
#2Jae Won Lee (UIUC: University of Illinois at Urbana–Champaign)
Last. Yong Su Jin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 52
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L-malic acid is widely used in the food, chemical, and pharmaceutical industries. Here, we report on production of malic acid from xylose, the second most abundant sugar in lignocellulosic hydrolysates, by engineered Saccharomyces cerevisiae. To enable malic acid production in a xylose-assimilating S. cerevisiae, we overexpressed PYC1 and PYC2, coding for pyruvate carboxylases, a truncated MDH3 coding for malate dehydrogenase, and SpMAE1, coding for a Schizosaccharomyces pombe malate transporter...
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