Papers 10000
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#1Yuta Matsuno (Tokai University)H-Index: 1
#2Yahia A. Amin (Aswan University)H-Index: 2
Last. Kazuhiko Imakawa (Tokai University)H-Index: 28
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In ruminants, various molecules are involved in regulating conceptus attachment and adhesion; however, molecules that maintain the conceptus adhesion have not been well characterized. We hypothesized that conceptus must produce a molecule(s), yet uncharacterized or overlooked, which maintain conceptus adhesion to the uterine epithelium. In this study, we aimed to identify new candidate(s) in conceptus secretory proteins responsible for maintaining conceptus adhesion in sheep. We performed RNA-se...
#1Fuhua Xu (OHSU: Oregon Health & Science University)H-Index: 4
#2Shally N. Wolf (Oregon National Primate Research Center)
Last. Jing Xu (OHSU: Oregon Health & Science University)H-Index: 17
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Vitamin D (VD) is a secosteroid hormone synthesized predominantly in the skin upon ultraviolet light exposure, which can also be obtained from dietary sources. In target cells, the bioactive VD binds to specific VD receptor to regulate downstream transcription of genes that are involved in a wide range of cellular processes. There is increasing recognition that the proper physiological levels of VD are critical for optimizing reproductive potential in women. The direct VD action in the ovary was...
#1María Silvia Ventimiglia (CONICET: National Scientific and Technical Research Council)
#2Natalin Jimena Valeff (CONICET: National Scientific and Technical Research Council)
Last. Federico JensenH-Index: 21
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Preterm birth (PTB), defined as birth occurring before 37 weeks of pregnancy, affects 5-18% of pregnancies and is the leading cause of neonatal morbidity and mortality worldwide. Although PTB is considered a syndrome, infection-induced inflammation accounts up to 50% of all cases. Despite the effort to reduce the incidence of PTB, it continues rising worldwide and current approaches for preventing or treating PTB are largely unsatisfactory. Probiotics are live microorganisms that, when administe...
#1Tetsuhiro Yokonishi (Kawasaki Medical School)
#2Blanche Capel (Duke University)H-Index: 67
Sertoli cells proliferate and construct seminiferous tubules during fetal life, then undergo differentiation and maturation in the prepubertal testes. In the adult testes, mature Sertoli cells maintain spermatogonia and support spermatogenesis during the entire lifetime. Although Sertoli-like cells have been derived from iPS cells, they tend to remain immature. To investigate whether Sertoli cells can spontaneously acquire the ability to support spermatogenesis when transferred into the adult te...
#1Shinnosuke Suzuki (UTSA: University of Texas at San Antonio)H-Index: 2
#2John R. McCarrey (UTSA: University of Texas at San Antonio)H-Index: 60
Last. Brian P. Hermann (UTSA: University of Texas at San Antonio)H-Index: 20
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Initiation of spermatogonial differentiation in the mouse testis begins with the response to retinoic acid (RA) characterized by activation of KIT and STRA8 expression. In the adult, spermatogonial differentiation is spatiotemporally coordinated by a pulse of RA every 8.6 days that is localized to stages VII-VIII of the seminiferous epithelial cycle. Dogmatically, progenitor spermatogonia that express retinoic acid receptor gamma (RARG) at these stages will differentiate in response to RA, but t...
#1Hossam El-Sheikh Ali (UK: University of Kentucky)H-Index: 5
#2Kirsten E. Scoggin (UK: University of Kentucky)H-Index: 17
Last. Barry A. Ball (UK: University of Kentucky)H-Index: 51
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Cervical remodeling is a critical component in both term and preterm labor in eutherian mammals. However, the molecular mechanisms underlying cervical remodeling remain poorly understood in the mare. The current study compared the transcriptome of the equine cervix (cervical mucosa (CM) and stroma (CS)) during placentitis (placentitis group, n=5) and normal prepartum mares (prepartum group, n=3) to normal pregnant mares (control group, n=4). Transcriptome analysis identified differentially expre...
#1Mohammed Hoque (SBU: Stony Brook University)
#2Danny Chen (SBU: Stony Brook University)
Last. Ken-Ichi Takemaru (SBU: Stony Brook University)H-Index: 27
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Cilia are evolutionarily conserved microtubule-based structures that perform diverse biological functions. Cilia are assembled on basal bodies and anchored to the plasma membrane via distal appendages. In the male reproductive tract, multicilia in efferent ducts (EDs) move in a whip-like motion to prevent sperm agglutination. Previously, we demonstrated that the distal appendage protein CEP164 recruits Chibby1 (Cby1) to basal bodies to facilitate basal body docking and ciliogenesis. Mice lacking...
#1Barry E. Perlman (Rutgers Biomedical and Health Sciences)H-Index: 1
#2Audrey A Merriam (Yale University)H-Index: 1
Last. Nataki C. Douglas (Rutgers Biomedical and Health Sciences)H-Index: 16
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In the 1st trimester of human pregnancy, low oxygen tension or hypoxia, is essential for proper placentation and placenta function. Low oxygen levels and activation of signaling pathways have been implicated as critical mediators in the promotion of trophoblast differentiation, migration, and invasion with inappropriate changes in oxygen tension and aberrant Notch signaling both individually reported as causative to abnormal placentation. Despite crosstalk between hypoxia and Notch signaling in ...
#1Rowena Smith (Edin.: University of Edinburgh)H-Index: 6
#2Susan J. PickeringH-Index: 5
Last. Chih-Jen Lin (Edin.: University of Edinburgh)H-Index: 64
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Elucidating the mechanisms underpinning fertilisation is essential to optimising IVF procedures. One of the critical steps involves paternal chromatin reprogramming, in which compacted sperm chromatin packed by protamines is removed by oocyte factors and new histones, including histone H3.3, are incorporated. HIRA is the main H3.3 chaperone governing this protamine-to-histone exchange. Failure of this step results in abnormally fertilised zygotes containing only 1 pronucleus (1PN), in contrast t...
#1Hong-Lan Song (CQMU: Chongqing Medical University)
#2Tai-Hang Liu (MOE: Chinese Ministry of Education)H-Index: 1
Last. Li-Juan Fu (CQMU: Chongqing Medical University)H-Index: 8
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The syncytiotrophoblast, derived from cytotrophoblast fusion, is responsible for maternal-fetal exchanges, secretion of pregnancy-related hormones, and fetal defense against pathogens. Inadequate cytotrophoblast fusion can lead to pregnancy disorders, such as preeclampsia and fetal growth restriction. However, little is known about the mechanism of cytotrophoblast fusion in both physiological and pathological pregnancy conditions. In this study, P57kip2 (P57), a cell cycle-dependent kinase inhib...
Top fields of study
Estrous cycle