Neuroimmunology and Neuroinflammation
Papers 1,322
1 page of 133 pages (1,322 results)
#1Young Nam KwonH-Index: 3
#1Young Nam Kwon (SNUH: Seoul National University Hospital)H-Index: 3
Last. Sung Hyuk HeoH-Index: 12
view all 23 authors...
Background and Objective null To investigate the clinical relevance of CSF myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) testing in a large multicenter cohort. null Methods null In this multicenter cohort study, paired serum-CSF samples from 474 patients with suspected inflammatory demyelinating disease (IDD) from 11 referral hospitals were included. After serum screening, patients were grouped into seropositive myelin oligodendrocyte glycoprotein antibody associated disease (MO...
#1Jens Ingwersen (HHU: Heinrich Heine University Düsseldorf)H-Index: 11
#2Jonas Graf (HHU: Heinrich Heine University Düsseldorf)H-Index: 10
Last. Sven G. Meuth (HHU: Heinrich Heine University Düsseldorf)H-Index: 6
view all 13 authors...
Background and Objectives null Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease primarily affecting the peripheral nervous system. However, several noncontrolled studies have suggested concomitant inflammatory CNS demyelination similar to multiple sclerosis. The aim of this study was to investigate an involvement of the visual pathway in patients with CIDP. null Methods null In this prospective cross-sectional study, we used high-resolution spectral-domain optica...
BACKGROUND AND OBJECTIVES: It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population. METHODS: Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective obs...
BACKGROUND AND OBJECTIVES To investigate whether children receiving immunosuppressive therapies for neuroimmunologic disorders had (1) increased susceptibility to SARS-CoV2 infection or to develop more severe forms of COVID-19; (2) increased relapses or autoimmune complications if infected; and (3) changes in health care delivery during the pandemic. METHODS Patients with and without immunosuppressive treatment were recruited to participate in a retrospective survey evaluating the period from Ma...
BACKGROUND AND OBJECTIVES: To define the clinical and pathologic correlations of compartmentalized perivascular B cells in postmortem progressive multiple sclerosis (MS) brains. METHODS: Brain slices were acquired from 11 people with secondary progressive (SP) MS, 5 people with primary progressive (PP) MS, and 4 controls. Brain slices were immunostained for B lymphocytes (CD20), T lymphocytes (CD3), cytotoxic T lymphocytes (CD8), neuronal neurofilaments (NF200), myelin (SMI94), macrophages/micro...
BACKGROUND AND OBJECTIVES The mechanisms of pain in patients with diabetic polyneuropathy are unknown. Studies have suggested a role of inflammation and increased neuropeptides peripherally in pain generation. This study examined the possible skin markers of painful diabetic polyneuropathy (P-DPN): macrophages, substance P (SP), and calcitonin gene-related peptide (CGRP). METHODS The participants were included from a large Danish cross-sectional clinical study of type 2 diabetes. We diagnosed de...
#1Michael Sy (UCI: University of California, Irvine)H-Index: 3
#2Erin Fromm (UCI: University of California, Irvine)
Last. Alexander U. Brandt (UCI: University of California, Irvine)H-Index: 47
view all 5 authors...
BACKGROUND AND OBJECTIVES There are limited data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine reactogenicity in persons with multiple sclerosis (PwMS) and how reactogenicity is affected by disease-modifying therapies (DMTs). The objective of this retrospective cross-sectional study was to generate real-world multiple sclerosis-specific vaccine safety information, particularly in the context of specific DMTs, and provide information to mitigate specific concerns in vacc...
Background and objectives null To determine the role of complement in the disease pathology of multifocal motor neuropathy (MMN), we investigated complement activation, and inhibition, on binding of MMN patient-derived immunoglobulin M (IgM) antibodies in an induced pluripotent stem cell (iPSC)-derived motor neuron (MN) model for MMN. null Methods null iPSC-derived MNs were characterized for the expression of complement receptors and membrane-bound regulators, for the binding of circulating IgM ...
#1Lorena Martín-Aguilar (UAB: Autonomous University of Barcelona)H-Index: 5
#2Cinta LleixàH-Index: 7
Last. Noemi de Luna (UNIMI: University of Milan)H-Index: 1
view all 43 authors...
BACKGROUND AND OBJECTIVES To study the clinical and laboratory features of antineurofascin-155 (NF155)-positive autoimmune nodopathy (AN). METHODS Patients with anti-NF155 antibodies detected on routine immunologic testing were included. Clinical characteristics, treatment response, and functional scales (modified Rankin Scale [mRS] and Inflammatory Rasch-built Overall Disability Scale [I-RODS]) were retrospectively collected at baseline and at the follow-up. Autoantibody and neurofilament light...
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