Neuroimmunology and Neuroinflammation
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Objectives null To evaluate the long-term effects of natalizumab (NTZ) on different features of intrathecal immunoglobulin (Ig) synthesis in patients with multiple sclerosis (MS) and to quantify the expression of α4-integrin in stages of B-cell maturation. null Methods null We combined a cross-sectional (49 NTZ-treated MS patients, mean treatment duration 5.1 years, and 47 untreated MS patients) and a longitudinal study (33 patients with MS before and during NTZ, mean treatment duration: 4.8 yea...
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#1Steven Cicero (Brigham and Women's Hospital)H-Index: 1
#2Eero Rissanen (Brigham and Women's Hospital)
Last. Tarun Singhal (Brigham and Women's Hospital)H-Index: 12
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An increasing number of disease-modifying therapies (DMTs) are being approved for treatment of multiple sclerosis …
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In the article “Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem …
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In recent years, the number of articles submitted to N2 has grown substantially. Currently, we are able to accept only a minority of submitted articles, and therefore, we must make difficult decisions regarding which articles will most benefit our readers and improve patient care. The extraordinary work of our reviewers facilitates this task. The dedication to reviewing for Neurology® Neuroimmunology & Neuroinflammation cannot be adequately conveyed. Your thoughtful comments regarding experiment...
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In the article “Discontinuation of Immunosuppressive Therapy in Patients With Neuromyelitis Optica …
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#1Jie Li (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Sam A. Bazzi (UTSW: University of Texas Southwestern Medical Center)
Last. Benjamin Greenberg (UTSW: University of Texas Southwestern Medical Center)H-Index: 42
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Objective null To determine whether distinct aquaporin-4 (AQP4)-IgG lineages play a role in neuromyelitis optica spectrum disorder (NMOSD) pathogenesis, we profiled the AQP4-IgG polyclonal serum repertoire and identified, quantified, and functionally characterized distinct AQP4-IgG lineages circulating in 2 patients with NMOSD. null Methods null We combined high-throughput sequencing and quantitative immunoproteomics to simultaneously determine the constituents of both the B-cell receptor (BCR) ...
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#1Georgina Arrambide (Autonomous University of Barcelona)H-Index: 20
Last. Mayra Gómez-MorenoH-Index: 1
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Objective null To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. null Methods null Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations ...
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#1Neda Zarghami Esfanhani (KP: Kaiser Permanente)
#2Annette Wundes (UW: University of Washington)H-Index: 12
Last. Scott D. Newsome (Johns Hopkins University)H-Index: 27
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A 31-year-old woman presented with fever, ataxia, double vision, confusion, and auditory hallucinations, preceded by 2 weeks of cough, increased oral secretions, and dermatomal rash. Her medical history was unremarkable. Her family history was notable for first-degree relatives with autoimmune
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OBJECTIVE To determine whether CSF interleukin 8 (IL-8) concentration can help to distinguish Guillain-Barre syndrome (GBS) from chronic inflammatory demyelinating polyneuropathy (CIDP) at the initial stage of the disease. METHODS We performed retrospective immunoassay of IL-8 in CSF, collected at the University Hospitals of Geneva between 2010 and 2018, from patients diagnosed with GBS (n = 45) and with CIDP (n = 30) according to the Brighton and European Federation of Neurological Societies/Pe...
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Top fields of study
Pathology
Antibody
Immunology
Disease
Multiple sclerosis
Medicine