Applied Cancer Research
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Cell culture (spheroid and 2D monolayer cultures) is an essential tool in drug discovery. Piperlongumine (PLN), a naturally occurring alkaloid present in the long pepper (Piper longum), has been implicated in the regulation of GSTP1 activity. In vitro treatment of cancer cells with PLN increases ROS (reactive oxygen species) levels and induces cell death, but its molecular mode of action has not been entirely elucidated. In this study, we correlated the antiproliferative effects (2D and 3D cultu...
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#1Amani A. Alrehaili (Taif University)H-Index: 2
#2Majed Al-Mourgi (Taif University)H-Index: 3
Last. Nermin Raafat (Zagazig University)H-Index: 7
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Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27kip1 is an inhibitor of a cycline-dependent kinase, its loss, can contribute to tumor progression. This study aimed to examine the importance of P27KIP1 protein in predicting the prognosis and response to neoadjuvant chemotherapy in patients with advanced ovarian epithelial cancer and to compare the outcomes of immunohistochemistry w...
1 CitationsSource
Last. Fábio Abreu Alves (USP: University of São Paulo)H-Index: 3
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Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-hodgkin’s lymphoma. In oral cavity represents approximately 2% of all malignancies. This report describes a rare mandibular involvement of DLBCL. A 56 year-old man was referred for evaluation of left mandible pain. In the anamnesis, the patient informed to be treating tooth pain in lasting 6 months. On oral evaluation, an intense mobility of the left mandibular second molar and a swelling in posterior left mandible were observe...
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#1Subhadip Pati (Bose Institute)H-Index: 1
#2Anandi Chowdhury (Bose Institute)H-Index: 1
Last. Gaurisankar Sa (Bose Institute)H-Index: 33
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A large number of cancer patients relapse after chemotherapeutic treatment. The immune system is capable of identifying and destroying cancer cells, so recent studies have highlighted the growing importance of using combinatorial chemotherapy and immunotherapy. However, many patients have innate or acquired resistance to immunotherapies. Long-term follow-up in a pooled meta-analysis exhibited long-term survival in approximately 20% of patients treated with immune checkpoint inhibitors or the ado...
1 CitationsSource
#1Suziene Caroline Silva Cardoso (USP: University of São Paulo)H-Index: 1
#2Andressa Duarte (USP: University of São Paulo)H-Index: 3
Last. Alfredo Ribeiro-Silva (USP: University of São Paulo)H-Index: 13
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Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumor of the head and neck region. Chk2 (Checkpoint kinase 2) is considered a tumor suppressor gene that acts on the cellular response to DNA damage. However, the role of Chk2 in OSCC prognosis is not yet fully understood. The objective of this study was to evaluate Chk2 immunoexpression in OSCC and to elucidate the association between its expression and clinicopathological parameters of prognostic importance, includi...
1 CitationsSource
#1Amadou Barrow (University of the Gambia)H-Index: 1
#2Adeyinka OnikanH-Index: 2
Last. Michael Ekholuenetale (UI: University of Ibadan)H-Index: 12
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Cervical cancer is a prominently diagnosed form of cancer in several resource-constrained settings particularly within the sub-Saharan African region. Globally, Africa region has the highest incidence and mortality rates of cervical cancer. The high prevalence has been attributed to several factors including lack of awareness of the disease. The aim of this paper is to explore the prevalence and factors associated with awareness of cervical cancer among women of reproductive age in Republic of B...
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#1Samuel Jellison (Oklahoma State University Center for Health Sciences)H-Index: 4
#2Nicholas Hoffsommer (Oklahoma State University Center for Health Sciences)
Last. Matt Vassar (Oklahoma State University Center for Health Sciences)H-Index: 20
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Randomized controlled trials (RCTs) play an integral role in childhood cancer research. Several efforts to improve the quality of reporting of clinical trials have been published in recent years, including the TIDieR checklist. Many reviews have since used TIDieR to evaluate how well RCTs are being reported, but no such study has yet been done in childhood cancer. The aim of this study is to evaluate adherence of RCTs involving acute lymphocytic leukemia (ALL) to the TIDieR checklist. The PubMed...
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#1Edwin Halliday (Royal Shrewsbury Hospital)
#1Edwin Halliday (Royal Shrewsbury Hospital)H-Index: 2
Last. Syed Farhan Ahsan (Royal Shrewsbury Hospital)
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Lymphoedema is a common side effect after treatment for head and neck cancer. Our treatment protocol involves staging the degree of lymphoedema and then offering treatment comprising skin care, manual lymphatic drainage, simple lymphatic drainage, compression and elastic therapeutic tape. The Glasgow Benefit Inventory is a validated post-interventional questionnaire applicable to otorhinolaryngology interventions which measures changes in health status. The aim of this study was to quantify the ...
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#1Anurag MehtaH-Index: 8
#1Anurag MehtaH-Index: 9
Last. Ullas BatraH-Index: 7
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Next-generation sequencing (NGS) based assay for finding an actionable driver in non-small-cell lung cancer is a less used modality in clinical practice. With a long list of actionable targets, limited tissue, arduous single-gene assays, the alternative of NGS for broad testing in one experiment looks attractive. We report here our experience with NGS for biomarker testing in hundred advanced lung cancer patients. Predictive biomarker testing was performed using the Ion AmpliSeq™ Cancer Hotspot ...
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#1Iris A. Lesser (UFV: University of the Fraser Valley)H-Index: 9
#2J. Prystupa (UFV: University of the Fraser Valley)H-Index: 1
Last. C. P Nienhuis (UFV: University of the Fraser Valley)H-Index: 1
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Cancer survivorship results in an increased number of physical and psychosocial health issues. Engaging in physical activity in natural environments is often thought of as restorative. Despite the potential benefits of engaging in physical activity in natural environments there are no sustainable community-based programs for cancer survivors that employ this form of physical activity. This study aims to evaluate the impact of an 8-week trail-walking (TW) program on anxiety in a population of adu...
2 CitationsSource
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