International journal of stem cells
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Papers 357
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Background and Objectives To seek out the role of mircoRNA (miR)-324-5p-modified adipose-derived stem cells (ADSCs) in post-myocardial infarction (MI) myocardial repair. Methods and Results Rat ADSCs were cultivated and then identified by morphologic observation, osteogenesis and adipogenesis induction assays and flow cytometry. Afterwards, ADSCs were modified by miR-324-5p lentiviral vector, with ADSC proliferation and migration measured. Then, rat MI model was established, which was treated by...
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#1Nasim Kiaie (UT: University of Tehran)H-Index: 8
#2Seyedeh Parvin Mousavi Ghanavati (Ahvaz Jundishapur University of Medical Sciences)H-Index: 1
Last. Rouhollah Mehdinavaz Aghdam (UT: University of Tehran)H-Index: 10
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Since the emergence of the novel coronavirus, named COVID-19, researchers are looking for a treatment to stop the devastating pandemic. During these efforts, mesenchymal stem cells (MSCs), the potential next generation of therapeutic methods with wide application for diseases, have successfully controlled cytokine storm following the virus infection. However, the use of MSCs has been limited due to the ethical issues, immunogenicity, and genetic modifications. Therefore, exosomes were introduced...
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#1Yuanshu Liu (MOE: Chinese Ministry of Education)H-Index: 1
#2Peng Zhang (University of Electronic Science and Technology of China)
Last. Rui Zhou (Boston Children's Hospital)
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Background and Objectives Manipulating different signaling pathways via small molecules could efficiently induce cardiomyocytes from human induced pluripotent stem cells (hiPSC). However, the effect of transcription factors on the hiPSC-directed cardiomyocytes differentiation remains unclear. Transcription factor, p53 has been demonstrated indispensable for the early embryonic development and mesendodermal differentiation of embryonic stem cells (ESC). We tested the hypothesis that p53 promotes ...
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#1Reza ArefNezhad (Shiraz University of Medical Sciences)H-Index: 4
#2Hossein Motedayyen (KAUMS: Kashan University of Medical Sciences)H-Index: 6
Last. Ali Mohammadi (IAU: Islamic Azad University)H-Index: 50
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Multiple sclerosis (MS) is an inflammatory disease of central nervous system (CNS). The mmune system plays an important role in its pathogenesis. Current treatments are unable to cure patients and prevent the progression of MS lesions. Stem cell-based cell therapy has opened a new window for MS treatment. Stem cells regulate immune responses and improve axonal remyelination. Stem cells can be obtained from different origins such as embryonic, neural, bone marrow, and adipose tissues. But yet the...
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#1Limin LiuH-Index: 1
#2Yao WuH-Index: 1
Last. Dangze SunH-Index: 1
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Background and Objectives Chronic kidney disease (CKD) has a major impact on the quality of life of patients, and renal fibrosis is a critical pathological change in the disease. It is very important to control the process of renal fibrosis to improve the quality of life of patients with CKD. The pathological mechanism of renal fibrosis is very complicated, and the current treatment strategy also has many flaws. Methods and Results To explore a better treatment, we collected exosomes from plurip...
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#1Xin Jin (CSU: Central South University)H-Index: 1
#2Jiali Hou (CSU: Central South University)H-Index: 1
Last. Xuan Sun (CSU: Central South University)H-Index: 1
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Background and objectives null Systemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory disease. In this study, preventive effect of single systemic human umbilical cord mesenchymal stem cells (UC-MSCs) transfusion on SSc was preliminarily explored. null Methods and results null SSc mouse model was established by daily intradermal injection of Hypochlorite (HOCl). SSc mice were treated by single transfusion of UC-MSCs at 0.625×105, ...
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#1Soojin Park (Catholic University of Korea)
#2Hee-Je Kim (Catholic University of Korea)H-Index: 25
Last. Areum HanH-Index: 14
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Background and objectives null The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M), a VEGFR-3 inhibiting chemical, was effectively restored the function of NK cells via the high expression of interferon- gamma (IFN-γ) in NK cells, as shown in our previous study. Although tremendous amount of clinical data using peptides are currently available in real clinic, pep...
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#1Myung-Jin Chung (KNU: Kyungpook National University)H-Index: 5
#2Ji-Yoon Son (KNU: Kyungpook National University)H-Index: 1
Last. Kyu-Shik Jeong (KNU: Kyungpook National University)H-Index: 33
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The therapeutic effects of mesenchymal stem cells (MSCs) in musculoskeletal diseases (MSDs) have been verified in many human and animal studies. Although some tissues contain MSCs, the number of cells harvested from those tissues and rate of proliferation in vitro are not enough for continuous transplantation. In order to produce and maintain stable MSCs, many attempts are made to induce differentiation from pluripotent stem cells (iPSCs) into MSCs. In particular, it is also known that the parac...
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Background and Objectives Human CD34+ hematopoietic stem cells can reconstitute the human hematopoietic system when transplanted into immunocompromised mice after irradiation. Human leukapheresis peripheral blood (LPB)- and cord blood (CB)-derived CD34+ cells have a similar capacity to reconstitute myeloid lineage cells in a humanized mice (hu-mice) model. However, potent stem cells, such as CB-CD34+ cells, efficiently reconstitute the lymphoid system in vivo compared to LPB-CD34+ cells. Modelin...
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Last. Zhaojin Du (Boston Children's Hospital)
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Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured understanding of underlying mechanisms. Recently microRNAs have emerged as a key player in the process of spermatogenesis. Expression profiling of miR-181a was carried out in murine testes and spermatocyte culture system. In vitro cellular and biochemical assays were used to examine the effect of miR...
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Top fields of study
Pathology
Mesenchymal stem cell
Stem cell
Medicine
Biology
Cell biology