Clinical and translational gastroenterology
Papers 762
1 page of 77 pages (762 results)
#1Anke H. M. van Vugt (Utrecht University)H-Index: 3
#1Anke H M van Vugt (UM: University of Michigan–Ann Arbor)
Last. Roderick H. J. Houwen (Utrecht University)H-Index: 60
view all 12 authors...
INTRODUCTION Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder. METHODS We investigated the effect of SSP2518 on GCC-mediated intracellular cyclic guanosine monophosphate (cGMP) levels and on GCC-mediated chloride secretion in intestinal organoids from 3 patients with distinct activating GCC mutations and from controls, with and without stimulation ...
#1Fujiao Duan (Zhengzhou University)H-Index: 9
#2Chunhua SongH-Index: 14
Last. Kaijuan WangH-Index: 5
view all 7 authors...
INTRODUCTION Single-nucleotide polymorphisms (SNPs) are used to stratify the risk of gastric cancer. However, no study included gastric cancer-related long noncoding RNA (lncRNA) SNPs into the risk model for evaluation. This study aimed to replicate the associations of 21 lncRNA SNPs and to construct an individual risk prediction model for gastric cancer. METHODS The bioinformatics method was used to screen gastric cancer-related lncRNA functional SNPs and verified in population. Gastric cancer ...
#1Hideaki Kinugasa (Okayama University)H-Index: 14
#2Hiromitsu Kanzaki (Okayama University)H-Index: 19
Last. Hiroyuki Okada (Okayama University)H-Index: 63
view all 10 authors...
INTRODUCTION The genomic characterization of primary nonampullary duodenal adenocarcinoma indicates a genetic resemblance to gastric and colorectal cancers. However, a correlation between the clinical and molecular characteristics of these cancers has not been established. This study aimed to elucidate the clinicopathological features of sporadic nonampullary duodenal epithelial tumors, including their molecular characteristics and prognostic factors. METHODS One hundred forty-eight patients wit...
#1Shinya Furukawa (Ehime University)H-Index: 25
#2Yoshio Ikeda (Ehime University)H-Index: 12
Last. Seiyuu SuzukiH-Index: 7
view all 18 authors...
INTRODUCTION Monocytes play an important role in innate immunity. Some epidemiological evidence indicates an association between peripheral blood monocytes and ulcerative colitis (UC). The association between peripheral blood monocytes and mucosal healing (MH), however, remains unclear. We evaluated this issue in patients with UC. METHODS Study subjects consisted of 272 Japanese patients with UC. Monocyte counts were taken in the morning after overnight fasting. Monocyte count was divided into t...
#1Robert W. Cowan (The University of Texas Health Science Center at Houston)
#1Robert W. Cowan (The University of Texas Health Science Center at Houston)H-Index: 12
Last. Melena D. Bellin (University of Minnesota)H-Index: 42
view all 11 authors...
INTRODUCTION Chronic pancreatitis is associated with an increased risk of developing pancreatic cancer, and patients with inherited forms of pancreatitis are at greatest risk. We investigated whether clinical severity of pancreatitis could also be an indicator of cancer risk independent of etiology by performing targeted DNA sequencing to assess the mutational burden in 55 cancer-associated genes. METHODS Using picodroplet digital polymerase chain reaction and next-generation sequencing, we repo...
#1Karine Suissa (BWH: Brigham and Women's Hospital)H-Index: 2
#2Seoyoung C. Kim (BWH: Brigham and Women's Hospital)H-Index: 43
Last. Elisabetta Patorno (BWH: Brigham and Women's Hospital)H-Index: 32
view all 3 authors...
Introduction null Quantitative and phenotypic analyses of duodenal intraepithelial lymphocytes (IELs) by flow cytometry (IEL lymphogram) confer specificity and enable the diagnosis even in unconventional presentations of celiac disease (CD). To evaluate the validity of the IEL lymphograms in the pediatric population for new insights into their use as biomarkers in the natural history of CD. null Methods null We retrospectively included 1,211 children (602 with active CD, 92 on a gluten-free diet...
#1Xiaoyun Zhang (SCU: Sichuan University)H-Index: 11
#2Yongjie Zhou (SCU: Sichuan University)H-Index: 12
Last. Tian-Fu Wen (SCU: Sichuan University)H-Index: 26
view all 8 authors...
INTRODUCTION Carbohydrate antigen 19-9 (CA19-9) and α-fetoprotein (AFP) are routinely tested in patients with liver malignancies before surgery. However, few reports have explored the relevance of the expression pattern of these 2 tumor markers regarding the prognosis of intrahepatic cholangiocarcinoma (ICC). We herein combined these 2 tumor markers to investigate the influence on ICC malignancy and patient prognosis. METHODS From March 2009 to December 2019, 519 consecutive patients with newly ...
#1Karan Mathur (IU: Indiana University)H-Index: 2
#2Areej MazharH-Index: 1
Last. Samer Gawrieh (IU: Indiana University)H-Index: 11
view all 10 authors...
INTRODUCTION The impact of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) on burden of cirrhotic and noncirrhotic hepatocellular carcinoma (HCC) has not been examined. We assessed recent trends in liver disease etiologies of HCC and proportion of noncirrhotic HCC since DAAs introduction. METHODS Clinical characteristics including presence or absence of underlying cirrhosis were collected from 2,623 patients diagnosed with HCC between 2009 and 2019 at 2 large US centers. Logistic reg...
#1Jorge D. Machicado (UM: University of Michigan–Ann Arbor)
#2Rawad MounzerH-Index: 15
Last. David C. Whitcomb (University of Pittsburgh)H-Index: 91
view all 13 authors...
INTRODUCTION Experimental data suggest that nonsteroidal antiinflammatory drugs may prevent disease severity and mortality in acute pancreatitis (AP). The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression. METHODS We conducted a single-center, quadruple-blinded, randomized, placebo-controlled trial. Eligible criteria were subjects with AP and SI...
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