Biochemistry and biophysics reports
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#1Mariko Mizuguchi (Tokyo Medical and Dental University)H-Index: 5
#2Toshifumi Hara (Aichi Gakuin University)
Last. Masataka Nakamura (Tokyo Medical and Dental University)H-Index: 39
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Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells. We recently found that the transcriptional factor Kruppel-like factor 2 (KLF2) binds to the CpG sequences in the hTERT promoter and inhibits hTERT gene expression in normal resting T-cells. The human T-cell line Kit 225 in the resting phase induced by the deprivation of interleukin (IL)-2 showed no decrease in the expression of hTERT, despite the h...
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#1Ravneet ChugH-Index: 1
#2Shruti MathurH-Index: 1
Last. Vinod Singh GourH-Index: 5
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#1Izzeddin Alsalahat (RMIT: RMIT University)H-Index: 2
#2Zubida M. Al-Majdoub (RMIT: RMIT University)H-Index: 6
Last. Sally Freeman (RMIT: RMIT University)H-Index: 25
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Abstract The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic benzylpenicillin (BP) can specifically bind to Aβ, modulate the process of aggregation and supress its cytotoxic effect, initially via a reversible binding interaction, followed by covalent bonding between specific functional groups (nucleophiles) within the Aβ peptide and the beta-lactam ring. Mass spectrometry and computational...
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#1P. Tandale (LPU: Lovely Professional University)
#2Neeraj Choudhary (LPU: Lovely Professional University)H-Index: 2
Last. Ashish Suttee (LPU: Lovely Professional University)H-Index: 4
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Abstract Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from 2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical ...
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#1Maho Shimizu (Nagaoka University of Technology)H-Index: 1
#2Saoko Tachikawa (Nagaoka University of Technology)H-Index: 5
Last. Kiyoshi Ohnuma (Nagaoka University of Technology)H-Index: 20
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Abstract Although thalidomide is highly teratogenic, it has been prescribed for treating multiple myeloma and Hansen's disease. However, its mechanism of action is not fully understood. Here, we employed a reverse transcription quantitative PCR array to measure the expression of 84 genes in human induced pluripotent stem cells (hiPSCs) and their mesodermal differentiation. Thalidomide altered the expression of undifferentiated marker genes in both cell types. Thalidomide affected more genes in t...
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#1Dimple Goyal (Panjab University, Chandigarh)H-Index: 1
#2Shabeer Ahmad (Panjab University, Chandigarh)
Last. Sukesh Chander Sharma (Panjab University, Chandigarh)H-Index: 13
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Abstract Plant polyphenols have been extensively studied for their chemopreventive properties for human health. Dextransucrase plays an essential role in synthesizing exopolysaccharides from its exclusive substrate sucrose in Streptococcus mutans. In the present study, the effect of polyphenols gallic acid and tannic acid was investigated on the dextransucrase activity. The enzyme was purified by ethanol precipitation followed by column chromatography by Sephadex G-200 gel chromatography, follow...
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#1Bhanubong Saiboonjan (KKU: Khon Kaen University)
#2Sittiruk Roytrakul (Thailand National Science and Technology Development Agency)H-Index: 26
Last. Wises Namwat (KKU: Khon Kaen University)H-Index: 11
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The existence of latent tuberculosis infection (LTBI) is one of the main obstacles hindering eradication of tuberculosis (TB). To better understand molecular mechanisms and explore biomarkers for the pathogen during LTBI, we cultured strains of Mycobacterium tuberculosis (Mtb) under stress conditions, mimicking those in the host granuloma intracellular environment, to induce entry into the non-replicating persistence stage. The stresses included hypoxia, low pH (5.0), iron deprivation (100 μM of...
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Abstract Reducing sugars and reactive aldehydes, such as glyceraldehyde, non-enzymatically react with amino or guanidino groups of proteins to form advanced glycation end-products (AGEs) by the Maillard reaction that involves Schiff base formation followed by Amadori rearrangement. AGEs are found relatively in abundance in the human eye and to accumulate at a higher rate in diseases that impair vision such as cataract, diabetic retinopathy or age-related macular degeneration. We identified two n...
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