Nature Biomedical Engineering
Papers 741
1 page of 75 pages (741 results)
#1Shixian Wen (USC: University of Southern California)H-Index: 2
#2Allen Yin (Facebook)H-Index: 4
Last. Laurent Itti (USC: University of Southern California)H-Index: 69
view all 6 authors...
For brain-computer interfaces (BCIs), obtaining sufficient training data for algorithms that map neural signals onto actions can be difficult, expensive or even impossible. Here we report the development and use of a generative model-a model that synthesizes a virtually unlimited number of new data distributions from a learned data distribution-that learns mappings between hand kinematics and the associated neural spike trains. The generative spike-train synthesizer is trained on data from one r...
#1Or Perlman (Harvard University)H-Index: 7
#2Hirotaka Ito (BWH: Brigham and Women's Hospital)H-Index: 16
Last. Christian T. Farrar (Harvard University)H-Index: 31
view all 10 authors...
Non-invasive imaging methods for detecting intratumoural viral spread and host responses to oncolytic virotherapy are either slow, lack specificity or require the use of radioactive or metal-based contrast agents. Here we show that in mice with glioblastoma multiforme, the early apoptotic responses to oncolytic virotherapy (characterized by decreased cytosolic pH and reduced protein synthesis) can be rapidly detected via chemical-exchange-saturation-transfer magnetic resonance fingerprinting (CE...
#1Di-Wei Zheng (WHU: Wuhan University)H-Index: 25
#2Wei-Wei Deng (WHU: Wuhan University)H-Index: 18
Last. Xian-Zheng Zhang (WHU: Wuhan University)H-Index: 98
view all 10 authors...
Because a host's immune system is affected by host-microbiota interactions, means of modulating the microbiota could be leveraged to augment the effectiveness of cancer therapies. Here we report that patients with oral squamous cell carcinoma (OSCC) whose tumours contained higher levels of bacteria of the genus Peptostreptococcus had higher probability of long-term survival. We then show that in mice with murine OSCC tumours injected with oral microbiota from patients with OSCCs, antitumour resp...
#1Rumana Rashid (Harvard University)H-Index: 11
#2Yu-An Chen (Harvard University)H-Index: 6
Last. Peter K. Sorger (Harvard University)H-Index: 103
view all 10 authors...
Multiplexed tissue imaging facilitates the diagnosis and understanding of complex disease traits. However, the analysis of such digital images heavily relies on the experience of anatomical pathologists for the review, annotation and description of tissue features. In addition, the wider use of data from tissue atlases in basic and translational research and in classrooms would benefit from software that facilitates the easy visualization and sharing of the images and the results of their analys...
#1Floris Jan Voskuil (UMCG: University Medical Center Groningen)H-Index: 4
#2Jasper Vonk (UMCG: University Medical Center Groningen)H-Index: 3
Last. Gooitzen M. van Dam (UMCG: University Medical Center Groningen)H-Index: 44
view all 8 authors...
The pathological assessment of surgical specimens during surgery can reduce the incidence of positive resection margins, which otherwise can result in additional surgeries or aggressive therapeutic regimens. To improve patient outcomes, intraoperative spectroscopic, fluorescence-based, structural, optoacoustic and radiological imaging techniques are being tested on freshly excised tissue. The specific clinical setting and tumour type largely determine whether endogenous or exogenous contrast is ...
#1Marcelo D. T. Torres (University of Pennsylvania)H-Index: 18
#2Marcelo C. R. Melo (University of Pennsylvania)H-Index: 8
Last. Cesar de la Fuente-Nunez (University of Pennsylvania)H-Index: 31
view all 5 authors...
The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for decades, traditional discovery strategies have not yielded new classes of antimicrobial. Here, by mining the human proteome via an algorithm that relies on the sequence length, net charge, average hydrophobicity and other physicochemical properties of antimicrobial peptides, we report the identification of 2,603 encrypted peptide antibiotics that are encoded in proteins with biological function unrelate...
#1Leonid Cherkassky (RPCI: Roswell Park Cancer Institute)H-Index: 1
#2Prasad S. Adusumilli (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 62
The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
#1Jung Seok Lee (Yale University)H-Index: 20
#2Patrick Han (Yale University)H-Index: 8
Last. José M. Carballido (Novartis)H-Index: 28
view all 17 authors...
#1Ishita Basu (Harvard University)H-Index: 10
#2Ali Yousefi (WPI: Worcester Polytechnic Institute)H-Index: 8
Last. Alik S. Widge (University of Minnesota)H-Index: 24
view all 15 authors...
Deficits in cognitive control-that is, in the ability to withhold a default pre-potent response in favour of a more adaptive choice-are common in depression, anxiety, addiction and other mental disorders. Here we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants' cognitive control during a conflict task. We also show that clo...
#1Zhuolong Zhou (IU: Indiana University)H-Index: 10
#2Kevin Van der Jeught (IU: Indiana University)H-Index: 13
Last. Haniyeh Eyvani (IU: Indiana University)H-Index: 9
view all 19 authors...
In breast cancer, genetic heterogeneity, the lack of actionable targets and immune evasion all contribute to the limited clinical response rates to immune checkpoint blockade therapy. Here, we report a high-throughput screen based on the functional interaction of mouse- or patient-derived breast tumour organoids and tumour-specific cytotoxic T cells for the identification of epigenetic inhibitors that promote antigen presentation and potentiate T-cell-mediated cytotoxicity. We show that the epig...
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