Vaccine
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#1Bradford D Gessner (Pfizer)H-Index: 9
#2Christian Theilacker (Pfizer)H-Index: 3
Last. Luis Jodar (Pfizer)H-Index: 11
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#1Chia-Yun Lo (CBER: Center for Biologics Evaluation and Research)H-Index: 14
#2Julia A. Misplon (CBER: Center for Biologics Evaluation and Research)H-Index: 15
Last. Suzanne L. Epstein (CBER: Center for Biologics Evaluation and Research)H-Index: 28
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Current influenza vaccines rely on inducing antibody responses to the rapidly evolving hemagglutinin (HA) and neuraminidase (NA) proteins, and thus need to be strain-matched. However, predictions of strains that will circulate are imperfect, and manufacturing of new vaccines based on them takes months. As an alternative, universal influenza vaccines target highly conserved antigens. In proof of concept studies of universal vaccine candidates in animal models challenge is generally conducted only...
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#1Frederik Schaltz-Buchholzer (OUH: Odense University Hospital)H-Index: 1
#2Adam Roth (Public Health Agency of Sweden)H-Index: 23
Last. Christine Stabell Benn (OUH: Odense University Hospital)
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Abstract null null Background null In randomized trials, Bacille Calmette-Guerin (BCG) vaccine has been associated with reduced all-cause mortality. BCG-induced Tuberculin Skin Test (TST) reactions have also been associated with reduced all-cause mortality. We aimed to assess the association between TST responses and subsequent mortality in three birth cohorts and conducted a meta-analysis of existing studies. null null null Methods null Observational study within three Guinea-Bissau BCG trial b...
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#1Nimrod RahamimovH-Index: 3
#1Nimrod Rahamimov (BIU: Bar-Ilan University)H-Index: 3
Last. Anna Chernihovsky (BIU: Bar-Ilan University)
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Abstract null null Background null Recent phase-3 clinical trials have demonstrated very encouraging results for mRNA based vaccines against COVID-19. Current FDA and manufacturer guidelines mandate intramuscular administration of these vaccines, as other administration routes may not provide the same levels of effectiveness and safety. Observing the vast amount of published media images of persons receiving their vaccines, the authors noted in many cases the injection technique involved skin bu...
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#2Iltaf HussainH-Index: 3
Last. Anees Ur Rehman (BZU: Bahauddin Zakariya University)H-Index: 1
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The current study aims to assess the beliefs of the general public in Pakistan towards conspiracy theories, acceptance, willingness to pay, and preference for the COVID-19 vaccine. A cross-sectional study was conducted through an online self-administered questionnaire during January 2021. The Chi-square test or Fisher exact test was utilized for statistical data analysis. A total of 2158 respondents completed the questionnaire, among them 1192 (55.2%) were male with 23.87 (SD: ±6.23) years as me...
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#1Chiu-Bin HsiaoH-Index: 3
#1Chiu-bin Hsiao (Allegheny General Hospital)H-Index: 2
Last. Supriya D. MahajanH-Index: 36
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The widespread use of combination antiretroviral therapy (cART) has led to the accelerated aging of the HIV-infected population, and these patients continue to have a range of mild to moderate HIV-associated neurocognitive disorders (HAND). Infection results in altered mitochondrial function. The HIV-1 viral protein Tat significantly alters mtDNA content and enhances oxidative stress in immune cells. Microglia are the immune cells of the central nervous system (CNS) that exhibit a significant mi...
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The medical and veterinary public health importance of ticks and tick-borne pathogens is increasing due to the expansion of the geographic ranges of both ticks and pathogens, increasing tick populations, growing incidence of tick-borne diseases, emerging tick transmitted pathogens, and continued challenges of achieving effective and sustained tick control. The past decades show an increasing interest in the immune-mediated control of tick infestations and pathogen transmission through the use of...
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#1Henry A. UtsetH-Index: 8
#2Jenna J. GuthmillerH-Index: 14
Last. Patrick C. WilsonH-Index: 63
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The generation of high affinity antibodies is a crucial aspect of immunity induced by vaccination or infection. Investigation into the B cells that produce these antibodies grants key insights into the effectiveness of novel immunogens to induce a lasting protective response against endemic or pandemic pathogens, such as influenza viruses, human immunodeficiency virus, or severe acute respiratory syndrome coronavirus-2. However, humoral immunity has largely been studied at the serological level,...
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Dengue virus (DENV) is a major global health problem, with over half of the world’s population at risk of infection. Despite over 60 years of efforts, no licensed vaccine suitable for population-based immunization against DENV is available. Here, we describe efforts to engineer epitope-based vaccines against DENV non-structural protein 1 (NS1). NS1 is present in DENV-infected cells as well as secreted into the blood of infected individuals. NS1 causes disruption of endothelial cell barriers, res...
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#1Tatenda T. Yemeke (UNC: University of North Carolina at Chapel Hill)H-Index: 6
#2Elizabeth A. Mitgang (The Graduate Center, CUNY)H-Index: 2
Last. Bruce Y. Lee (The Graduate Center, CUNY)H-Index: 59
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Abstract null null Introduction null Understanding the costs to increase vaccination demand among under-vaccinated populations, as well as costs incurred by beneficiaries and caregivers for reaching vaccination sites, is essential to improving vaccination coverage. However, there have not been systematic analyses documenting such costs for beneficiaries and caregivers seeking vaccination. null null null Methods null We searched PubMed, Scopus, and the Immunization Delivery Cost Catalogue (IDCC) ...
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