Journal of Trauma-injury Infection and Critical Care
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#1Xiaowu Wu (DA: United States Department of the Army)H-Index: 17
Last. Andrew P. CapH-Index: 41
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BACKGROUND Mesenchymal stromal cells (MSC) express surface tissue factor (TF), which may affect hemostasis and detract from therapeutic outcomes of MSCs if administered intravenously (IV). In this study, we determine a safe dose of MSCs for IV administration, and further demonstrate the impact of IV-MSC on acute traumatic coagulopathy (ATC) in rats. METHODS TF expression of rat bone marrow derived MSC (BMSC) or adipose derived MSC (AMSC) was detected by immunohistochemistry and ELISA. The coagul...
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Trauma patients are at increased risk of venous thromboembolism (VTE), which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). Pharmacologic VTE prophylaxis is a critical component of optimal trauma care that significantly decreases VTE risk. Optimal VTE prophylaxis protocols must manage the risk of VTE with the competing risk of hemorrhage in patients following significant trauma. Currently, there is variability in VTE prophylaxis protocols across trauma centers. In an attem...
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BACKGROUND Traumatic cardiac arrests (TCA) are associated with high mortality and the majority of deaths occur at the prehospital scene. The aim of the present study was to assess, in a pre-hospital physician-led emergency medical system, the factors associated with sustained return of spontaneous circulation (ROSC) in TCA, including advanced life procedures. The secondary objectives were to assess factors associated with 30-day survival in TCA, evaluate neurological recovery in survivors, and d...
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#1Joseph J Lee (USU: Uniformed Services University of the Health Sciences)H-Index: 1
#2Andrew HallH-Index: 2
Last. Matthew D. TadlockH-Index: 7
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With the current drawdown of military operations and attrition of experienced personnel, Military-Civilian Partnerships (MCP) will be integral to preparing forward surgical teams to deploy. This review of the literature from 1980 through 2020 describes the characteristics of these complex relationships. Each identified MCP article was evaluated for measured MCP outcomes and classified using the Evidence Level of Individual Studies (ELIS) framework. From this review, a framework was developed for...
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#1Todd W Costantini (LLU: Loma Linda University)
#2Raul CoimbraH-Index: 81
Last. Brian P. EliceiriH-Index: 47
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BACKGROUND The systemic inflammatory response (SIRS) drives late morbidity and mortality after injury. The α7 nicotinic acetylcholine receptor (α7nAchR) expressed on immune cells regulates the vagal anti-inflammatory pathway that prevents an overwhelming SIRS response to injury. Non-specific pharmacologic stimulation of the vagus nerve has been evaluated as a potential therapeutic to limit SIRS. Unfortunately, the results of clinical trials have been underwhelming. We hypothesized that directly ...
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#1Torbjorg Holtestaul (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Ian F. JonesH-Index: 2
Last. Matthew J. EckertH-Index: 19
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BACKGROUND Management of noncompressible truncal hemorrhage utilizing REBOA requires arterial pressure monitoring that can be logistically challenging in austere or emergency settings. Novel pressure transducer devices such as the Centurion COMPASS® device (CD) offer an alternative to traditional monitoring systems. We sought to assess the feasibility of maintaining permissive hypotension during intermittent REBOA in a porcine model guided by CD monitoring. METHODS Eight Yorkshire swine underwen...
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#1Peter Abraham (UAB: University of Alabama at Birmingham)H-Index: 2
#2Brandon M. CrowleyH-Index: 1
Last. Jan O. JansenH-Index: 23
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BACKGROUND Understanding geographic patterns of injury is essential to operating an effective trauma system and targeting injury prevention. Choropleth maps are helpful in showing spatial relationships, but are unable to provide estimates of spread or degrees of confidence. Funnel plots overcome this issue and are a recommended graphical aid for comparisons that allow quantification of precision. The purpose of this project was to demonstrate the complementary roles of choropleth maps and funnel...
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#1Johannes Zipperle (Paracelsus Private Medical University of Salzburg)H-Index: 11
Last. Herbert SchöchlH-Index: 41
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BACKGROUND Heparan sulfate is an integral component of the glycocalyx that provides an anticoagulant layer close to the endothelium. Hypoperfusion, inflammation and sympathoadrenal activation following major trauma result in glycocalyx shedding and subsequent release of heparan sulfate into the bloodstream. The possible anticoagulant effect of this "auto-heparinization" has been suggested as a potential driver of trauma-induced coagulopathy. We investigated whether thromboelastometry can be used...
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BACKGROUND The National Academies of Sciences, Engineering, and Medicine 2016 trauma system report recommended a National Trauma Research Action Plan (NTRAP) to strengthen and guide future trauma research. To address this recommendation, 11 expert panels completed a Delphi survey process to create a comprehensive research agenda, spanning the continuum of trauma care. We describe the gap analysis and high priority research questions generated from the NTRAP panel on prehospital and mass casualty...
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