Cancer Research and Treatment
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3.76
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1518
Papers 1680
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#1Jun Zeng (NCU: Nanchang University)
#2Xiao-qing Xiao (NCU: Nanchang University)
Last. Zhi-yong Zhou (NCU: Nanchang University)
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Purpose Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF E3 ligases in the pathogenesis of colorectal cancer (CRC) remain obscure. Materials and Methods The cancerous and adjacent noncancerous tissues from CRC patients were collected, and protein levels were analyzed. Lentiviral short hairpin RNA (shRNA) and plasmid t...
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#1Ozlem Ozkaya Akagunduz (Ege University)H-Index: 5
#2Suzan Guven Yilmaz (Ege University)H-Index: 11
Last. Mustafa Esassolak (Ege University)H-Index: 9
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Purpose null To evaluate the radiation induced adverse effects on ocular structures in head and neck cancer patients and investigate the radiation dose-volume effects on the cornea, lacrimal gland, retina, optic nerve and chiasm. null Materials and methods null A total of 38 eyes of 19 patients were included in this prospective, cohort study. All patients underwent complete ophthalmological examination in addition to contrast sensitivity, visual field and visual evoked potentials (VEP) tests. Op...
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#1J.H. Kim (KU: Korea University)H-Index: 4
#2Bokyung Ahn (UOU: University of Ulsan)
Last. Jong Hoon Kim (UOU: University of Ulsan)H-Index: 39
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Purpose This study aimed to evaluate the real-world efficacy of immune checkpoint inhibitors (ICIs), and to identify clinicolaboratory factors to predict treatment outcomes in patients with advanced esophageal squamous cell carcinoma (ESCC) receiving ICIs. Materials and Methods Sixty patients with metastatic or unresectable ESCC treated with nivolumab (n=48) or pembrolizumab (n=12) as ≥ second-line treatment between 2016 and 2019 at Asan Medical Center were included. Results The median age of th...
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#1Dong-Yun Kim (Seoul National University Hospital)
#2Hong-Gyun Wu (Seoul National University Hospital)H-Index: 2
Last. Tack-Kyun KwonH-Index: 14
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Purpose null To compare the outcomes of primary radiotherapy (RT) versus surgery in early-stage human papilloma virus-positive oropharyngeal squamous cell carcinoma (hpv+OPC), and investigate the preoperative clinical factors that can predict the requirement for postoperative adjuvant treatment. null Materials and methods null This multicenter study included 166 patients with AJCC 8th edition-Stages I-II hpv+OPC. Sixty (36.1%) and 106 (63.9%) patients underwent primary (CC)RT and surgery, respec...
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#1Hyehyun Jeong (UOU: University of Ulsan)H-Index: 4
#2Jae Ho Jeong (UOU: University of Ulsan)H-Index: 8
Last. Sung-Bae Kim (UOU: University of Ulsan)H-Index: 57
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Purpose In hormone receptor-positive, HER2-negative metastatic breast cancer (HR+ HER2- MBC), the mainstay treatment options include cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and everolimus (EVE) in combination with endocrine treatment. This study aims to compare the outcomes of the following treatment sequences: CDK4/6i followed by EVE and EVE followed by CDK4/6i. Materials and Methods Data from HR+ HER2- MBC patients treated between Jan. 2014 and Nov. 2020 with both CDK4/6i and EVE were...
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#1Kyung Su Kim (Ewha Womans University)H-Index: 2
#2Hong-Gyun Wu (Seoul National University Hospital)H-Index: 2
Charged-particle therapy (CPT) such as proton beam therapy (PBT) and carbon-ion radiotherapy (CIRT) exhibit substantial physical and biological advantages compared to conventional photon radiotherapy. As it can reduce the amount of radiation irradiated in the normal organ, CPT has been mainly applied to pediatric cancer and radioresistent tumors in the eloquent area. Although there is a possibility that more patients can benefit from it, high set-up cost and dearth of high level of clinical evid...
1 CitationsSource
#1Jong Min Park (Seoul National University Hospital)H-Index: 17
#2Jung In Kim (Seoul National University Hospital)H-Index: 15
Last. Hong-Gyun Wu (Seoul National University Hospital)H-Index: 2
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Charted-particle therapy (CPT) benefits cancer patients by localizing doses in the tumor volume while minimizing the doses delivered to normal tissue through its unique physical and biological characteristics. The world's first CPT applied on humans was proton beam therapy (PBT), which was performed in the mid-1950s. Among heavy ions, carbon ions showed the most favorable biological characteristics for the treatment of cancer patients. Carbon ions show coincidence between the Bragg peak and maxi...
1 CitationsSource
#1Hwa Kyung Byun (Yonsei University)H-Index: 7
#2Min Cheol Han (Yonsei University)H-Index: 3
Last. Yong Bae Kim (Yonsei University)H-Index: 22
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Particle therapy is a promising and evolving modality of radiotherapy that can be used to treat tumors that are radioresistant to conventional photon beam radiotherapy. It has unique biological and physical advantages compared with conventional radiotherapy. The characteristic feature of particle therapy is the "Bragg peak," a steep and localized peak of dose, that enables precise delivery of the radiation dose to the tumor while effectively sparing normal organs. Especially, the charged particl...
1 CitationsSource
#1Eui Kyu Chie (New Generation University College)H-Index: 27
#2Yong Chan Ahn (SMC: Samsung Medical Center)H-Index: 43
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#1Mohamed H. Osman (Zagazig University)H-Index: 3
Last. Jeonghyun Kang (Yonsei University)H-Index: 19
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Purpose null Machine learning (ML) is a strong candidate for making accurate predictions, as we can use large amount of data with powerful computational algorithms. We developed a ML based model to predict survival of patients with colorectal cancer (CRC) using data from 2 independent datasets. null Materials and methods null A total of 364,316 and 1,572 CRC patients were included from the Surveillance, Epidemiology, and End results (SEER) and a Korean dataset, respectively. As SEER combines dat...
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