Oxidative Medicine and Cellular Longevity
Papers 5080
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#1Zhu GuoH-Index: 4
#2Weiliang SuH-Index: 1
Last. Hongfei XiangH-Index: 6
view all 16 authors...
Objective. Low back pain (LBP) is one of the top three causes of disability in developed countries, and intervertebral disc degeneration (IDD) is a major contributor to LBP. In the process of IDD, there is a gradual decrease in nucleus pulposus cells (NPCs) and extracellular matrix (ECM). Exosomes are important exocrine mediators of stem cells that can act directly on cells for tissue repair and regeneration. In this study, we determined the antisenescence, cell proliferation promotion, and ECM ...
Acute ischemic stroke (AIS) is a major cause of acquired adult disability and death. Our previous studies proved the efficacy and effectiveness of Tanhuo decoction (THD) on AIS. However, the therapeutic mechanism remains unclear. We recruited 49 AIS patients and 30 healthy people to explore the effects of THD+basic treatment on the poststroke gut microbiota of AIS patients using 16S rRNA sequencing, in which 23 patients received basic treatment (control group) and 26 patients received THD+basic ...
Atherosclerosis (AS) is a chronic metabolic disease in arterial walls, characterized by lipid deposition and persistent aseptic inflammation. AS is regarded as the basis of a variety of cardiovascular and cerebrovascular diseases. It is widely acknowledged that macrophages would become foam cells after internalizing lipoprotein particles, which is an initial factor in atherogenesis. Here, we showed the influences of Bruton’s tyrosine kinase (BTK) in macrophage-mediated AS and how BTK regulates t...
#1Xiaowei Wang (Fudan University)H-Index: 1
#2Tingting Ji (Fudan University)H-Index: 6
Last. Shoujun Bai (Fudan University)H-Index: 6
view all 5 authors...
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease. Although numerous reports have demonstrated a correlation between epithelial-mesenchymal transition (EMT) and renal fibrosis, how these processes lead to tubular dysfunction remains unclear. Here, we show that FOXO3a protects kidneys from injury in type II DN by increasing Sirt6 expression, which deacetylates Smad3 and inhibits its transcriptional activity. The results showed that progressive EMT in the kidneys from d...
#1Changzhao Gao (JLU: Jilin University)
#2Fei Yin (JLU: Jilin University)H-Index: 10
Last. Qingsan Zhu (JLU: Jilin University)H-Index: 2
view all 7 authors...
Spinal cord injury (SCI) causes a significant physical, emotional, social, and economic burden to millions of people. MicroRNAs are known players in the regulatory circuitry of the neural repair in SCI. However, most microRNAs remain uncharacterized. Here, we demonstrate the neuroprotection of microRNA-145 (miR-145) after SCI in vivo and in vitro. In silico analysis predicted the target gene KDM6A of miR-145. The rat SCI model was developed by weight drop, and lipopolysaccharide- (LPS-) induced ...
#1Anna Santarsiero (University of Basilicata)H-Index: 3
#2Paolo Convertini (University of Basilicata)H-Index: 15
Last. Vittoria Infantino (University of Basilicata)H-Index: 21
view all 13 authors...
Phenolic compounds of red wine powder (RWP) extracted from the Italian red wine Aglianico del Vulture have been investigated for the potential immunomodulatory and anti-inflammatory capacity on human macrophages. These compounds reduce the secretion of IL-1β, IL-6, and TNF-α proinflammatory cytokines and increase the release of IL-10 anti-inflammatory cytokine induced by lipopolysaccharide (LPS). In addition, RWP restores Annexin A1 levels, thus involving activation of proresolutive pathways. No...
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#1Chunmei Zhang (MOE: Chinese Ministry of Education)H-Index: 3
#2Mengying Suo (MOE: Chinese Ministry of Education)
Last. Peili Bu (MOE: Chinese Ministry of Education)H-Index: 8
view all 11 authors...
Oxidative stress and apoptosis play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The purpose of our study was to investigate the protective effects and mechanisms of melatonin against CI-AKI in a CI-AKI mouse model and NRK-52E cells. We established the CI-AKI model in mice, and the animals were pretreated with melatonin (20 mg/kg). Our results demonstrated that melatonin treatment exerted a renoprotective effect by decreasing the level of serum creatinine (S...
#1Rengasamy Balakrishnan (Konkuk University)H-Index: 5
#2Shofiul Azam (Konkuk University)H-Index: 7
Last. Dong-Kug Choi (Konkuk University)H-Index: 54
view all 5 authors...
Parkinson’s disease (PD) is the second-most common neurodegenerative chronic disease affecting both cognitive performance and motor functions in aged people. Yet despite the prevalence of this disease, the current therapeutic options for the management of PD can only alleviate motor symptoms. Research has explored novel substances for naturally derived antioxidant phytochemicals with potential therapeutic benefits for PD patients through their neuroprotective mechanism, targeting oxidative stres...
#1Shou-Qian Dai (Soochow University (Suzhou))H-Index: 1
#2Xiu Shi (Soochow University (Suzhou))H-Index: 1
Last. Huilin Yang (Soochow University (Suzhou))H-Index: 49
view all 6 authors...
Objective. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, a representative traditional Chinese medicine. The aim of the study was to investigate the capability of STS to reverse injury-induced intervertebral disc degeneration (IDD) and explore the potential mechanisms. Methods. Forty adult rats were randomly allocated into groups (control, IDD, STS10, and STS20). An IDD model was established by puncturing the Co8-9 disc using a needle. Rats in the STS grou...
#1Gang Gong (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 1
#2Yu-Li Shen (SHU: Shanghai University)H-Index: 5
Last. Hong Zhang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 58
view all 10 authors...
Cervical cancer is a common female malignant tumor that seriously threatens human health. This study explored the anticervical cancer effects and potential mechanisms of Rotundifuran (RTF), a natural product isolated from Vitex trifolia L. In this study, we found that RTF can suppress the proliferation of cervical cancer cell lines, including HeLa and SiHa cells (with the IC50 less than 10 μM), via induction of apoptosis in vitro, and the antitumor effect of RTF is further confirmed on the HeLa ...
Top fields of study
Oxidative stress
Reactive oxygen species
Diabetes mellitus