Oxidative Medicine and Cellular Longevity
Papers 5,621
1 page of 563 pages (5,621 results)
Last. Chunpeng Craig Wan (JXAU: Jiangxi Agricultural University)
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Huge epidemiological and clinical studies have confirmed that black tea is a rich source of health-promoting ingredients, such as catechins and theaflavins (TFs). Furthermore, TF derivatives mainly include theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3 null null null null null - gallate (TF2B), and theaflavin-3,3 null null null null null - digallate (TF3). All of these TFs exhibit extensive usages in pharmaceutics, foods, and traditional medication systems. Various indepth studies r...
#1Qingtian Zhu (Yangzhou University)
#2Lu Hao (ZJU: Zhejiang University)H-Index: 3
Last. Xinnong Liu (Yangzhou University)H-Index: 4
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As a calcium-regulated protein, CaMK II is closely related to cell death, and it participates in the development of pathological processes such as reperfusion injury, myocardial infarction, and oligodendrocyte death. The function of CaMK II activation in acute pancreatitis (AP) remains unclear. In our study, we confirmed that the expression of p-CaMK II was increased significantly and consistently in injured pancreatic tissues after caerulein-induced AP. Then, we found that KN93, an inhibitor of...
#1Yu-Bo Ma (XJTU: Xi'an Jiaotong University)H-Index: 1
#2Ming GaoH-Index: 5
Last. Lian-Dong Zhang (XJTU: Xi'an Jiaotong University)H-Index: 6
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In the past two decades, testicular tissue grafting and xenografting have been well established, with the production of fertilization-competent sperm in some studies. However, few studies have been carried out to observe the development of grafted prepubertal testicular tissue of rats and compare the biological differences between in situ testis and grafted testis. In this study, we established the prepubertal testicular tissue xenografting model using a 22-day-old rat and evaluated certain para...
#1Wenpei Chen (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 6
#2Yuxin Ye (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 1
Last. Baoqin Lin (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 5
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Dry age-related macular degeneration (dAMD) is a chronic degenerative ophthalmopathy that leads to serious burden of visual impairment. Antioxidation in retinal pigment epithelium (RPE) cells is considered as a potential treatment for dAMD. Our previous studies have showed that naringenin (NAR) protects RPE cells from oxidative damage partly through SIRT1-mediated antioxidation. In this study, we tested the hypothesis that the Nrf2 signaling is another protective mechanism of NAR on dAMD. NaIO3-...
#1Hui-Qin Li (NU: Nanjing University)
#2Sheng-Nan Xia (NU: Nanjing University)H-Index: 3
Last. Xiang Cao (NU: Nanjing University)H-Index: 10
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Ischemic stroke is a severe and acute neurological disorder with limited therapeutic strategies currently available. Oxidative stress is one of the critical pathological factors in ischemia/reperfusion injury, and high levels of reactive oxygen species (ROS) may drive neuronal apoptosis. Rescuing neurons in the penumbra is a potential way to recover from ischemic stroke. Endogenous levels of the potent ROS quencher glutathione (GSH) decrease significantly after cerebral ischemia. Here, we aimed ...
Vitamin D3, as an indispensable and fat-soluble micronutrient, plays an important role in the health of humans and animals. At present, studies are focusing on the calcium absorption and immunoregulation function of vitamin D3; this study was aimed at exploring the antioxidative stress ability of vitamin D3 on diquat-induced intestinal dysfunction of ICR mice and the underlying mechanism. The results showed that oral gavage of vitamin D3 daily significantly improved the body weight gain and immu...
#1Jiabao Hou (WHU: Wuhan University)H-Index: 8
#2Qianni Shen (WHU: Wuhan University)H-Index: 3
Last. Bo Zhao (WHU: Wuhan University)H-Index: 16
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Oxidative stress and apoptosis contribute to the progression of cerebral ischemia/reperfusion (I/R) injury. Ubiquitin-specific protease 29 (USP29) is abundantly expressed in the brain and plays critical roles in regulating oxidative stress and cell apoptosis. The purpose of the present study is to investigate the role and underlying mechanisms of USP29 in cerebral I/R injury. Neuron-specific USP29 knockout mice were generated and subjected to cerebral I/R surgery. For USP29 overexpression, mice ...
#1Yufeng Zhang (WHU: Wuhan University)H-Index: 1
#1Yufeng Zhang (WHU: Wuhan University)H-Index: 54
Last. Lin Cai (WHU: Wuhan University)H-Index: 13
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Bone resorption diseases, including osteoporosis, are usually caused by excessive osteoclastogenesis. Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian serine/threonine kinase, may participate in the regulation of bone homeostasis and osteolytic metastasis. In this study, ULK1 expression during osteoclastogenesis was detected with RT-PCR. We knocked down or overexpressed ULK1 through siRNA or lentiviral transduction in bone marrow macrophage (BMM). TRAP and phalloidin staining were p...
#1Vladimir Mihailović (University of Kragujevac)H-Index: 17
#2Jelena S. Katanić Stanković (University of Kragujevac)H-Index: 5
Last. Gvozden Rosic (University of Kragujevac)H-Index: 10
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Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for th...
#1Jialin He (CSU: Central South University)H-Index: 4
#2Jianyang Liu (CSU: Central South University)H-Index: 4
Last. Ming Lu (HNU: Hunan Normal University)H-Index: 10
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The mechanism of Golgi apparatus (GA) stress responses mediated by GOLPH3 has been widely studied in ischemic stroke, and the neuroprotection effect of olfactory mucosa mesenchymal stem cells (OM-MSCs) against cerebral ischemia/reperfusion injury (IRI) has been preliminarily presented. However, the exact role of OM-MSCs in the GA stress response following cerebral IRI remains to be elucidated. In the present study, we used an oxygen-glucose deprivation/reoxygenation (OGD/R) model and reversible ...
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