Expert Opinion on Drug Safety
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#1Patrick M. HonoreH-Index: 19
#2Sebastien RedantH-Index: 6
Last. David De BelsH-Index: 16
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#1Neil Vargesson (Aberd.: University of Aberdeen)H-Index: 22
#2Trent D. Stephens (ISU: Idaho State University)H-Index: 14
Thalidomide is used around the world today to effectively treat inflammatory and cancer conditions. Yet, 60 years ago, it was withdrawn from the market. What do we know about its mechanisms of acti...
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#1Mohamed Ali (Ain Shams University)H-Index: 8
#2Mohamed F. RaslanH-Index: 4
Last. Ayman Al-Hendy (U of C: University of Chicago)H-Index: 44
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Introduction null Uterine fibroids (UFs) are the most prevalent benign neoplastic threat originating from myometria of reproductive age women, with profound financial load valued in hundreds of billions of dollars. Unfortunately, there is no curative treatment so far except surgery and available pharmacological treatments are restricted for short-term treatment options. Thus, there is a large unmet need in the UF space for noninvasive therapeutics. null Areas covered null Authors reviewed litera...
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#1Kanako Kurihara (Fukuoka University)H-Index: 1
#2Takayasu Mishima (Fukuoka University)H-Index: 9
Last. Yoshio Tsuboi (Fukuoka University)H-Index: 51
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Introduction null While levodopa is still the most effective treatment for Parkinson's disease, concerns about long-term complications such as wearing-off and dyskinesia with levodopa usage remain. null Areas covered null : Safinamide is a highly selective and reversible monoamine oxidase B inhibitor introduced in the European Union, Japan, and the United States as an adjunctive agent to levodopa in PD patients with motor fluctuation. This review outlines the pharmacological properties, therapeu...
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#1Luigi ScarpatoH-Index: 2
#2Lucia FestinoH-Index: 14
Last. Paolo A. AsciertoH-Index: 91
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INTRODUCTION The development of new targeted therapies has considerably changed the therapeutic paradigm of melanoma, significantly increasing overall survival (OS) and progression-free survival (PFS). However, skin-related adverse sequelae might occur and impact on patients' quality of life. AREAS COVERED In this article we will cover the most important dermatological toxicities related to BRAF and MEK-inhibitors, along with updated management strategies. EXPERT OPINION BRAF inhibitors have rep...
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#1Yajnavalka Banerjee (University of Medicine and Health Sciences)H-Index: 16
#2Anca Pantea Stoian (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 11
Last. Manfredi Rizzo (USC: University of South Carolina)H-Index: 64
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Introduction null Inclisiran is a novel posttranscriptional gene silencing therapy that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis by RNA interference and has a potent, dose-dependent, durable effect in lowering LDL-C, and therefore is an effective drug to treat dyslipidemia, reducing the risk for acute cardiovascular (CV) events. It is safe and well-tolerated. null Areas covered null This paper aims to review the mechanism of action of inclisiran while evaluating i...
1 CitationsSource
#2Amir Krivoy (TAU: Tel Aviv University)H-Index: 17
Last. Sukhi Shergill (South London and Maudsley NHS Foundation Trust)H-Index: 16
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Introduction null Antipsychotic pharmacotherapy is considered first-line treatment in schizophrenia-related disorders and is associated with favorable prognosis and lower mortality rates. However, low adherence rates present a major clinical challenge. In this paper we will review contemporary approaches to improve adherence to antipsychotic treatment, considering their mechanism of action, safety, tolerability and acceptability. null Areas covered null Novel pharmacological delivery methods suc...
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#1Markus Mintert (International Flavors & Fragrances, Inc.)
#2Michael Kerry (International Flavors & Fragrances, Inc.)
Last. Meinolf Brackhagen (International Flavors & Fragrances, Inc.)
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#1Ming-Ming Yan (Fudan University)H-Index: 1
#2Shu-Shan Wu (UNMC: University of Nebraska Medical Center)
Last. Xiaoyan Qiu (Fudan University)
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Objectives:Real world studies have started to emerged on occurrence of venous thromboembolism (VTE) with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, but still deserve constant surveillance and evaluation. This study was to analyze this association. Methods: Adverse event cases were acquired from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database betweenJanuary 1st 2015 and December 31st 2020.Signals indicating association between CDK 4/6 inhibitors and V...
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#1Janne K Mortensen (Aarhus University Hospital)
#2Grethe Andersen (Aarhus University Hospital)H-Index: 52
Introduction null With the development of selective serotonin reuptake inhibitors (SSRI), a relatively uncomplicated treatment of depression and a safer alternative to tricyclic antidepressants was introduced. Any medical treatment has potential safety risks, however, and these risks should also be considered when prescribing SSRIs. null Areas covered null The present review focuses on safety considerations when prescribing SSRIs to patients with previous stroke and myocardial infarction, as dep...
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