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#1Seyed Reza Mirhafez (MUMS: Mashhad University of Medical Sciences)H-Index: 16
#2Seyedeh Hamideh Khadem (MUMS: Mashhad University of Medical Sciences)
Last. Majid Ghayour-Mobarhan (MUMS: Mashhad University of Medical Sciences)H-Index: 46
view all 9 authors...
Coronary artery bypass grafting (CABG) surgery with two methods (on-pump or off-pump) can be used to rescue individuals with severe coronary artery disease (CAD). Each method might cause an inflammatory response, which can lead to some complications. The aim of this study was to compare the changes in serum concentrations of IFN-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, MCP-1, and epidermal growth factor between the two CABG surgery method...
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#1Ying Li (Anhui Medical University)H-Index: 6
#2Meng-Ya Jiang (Anhui Medical University)H-Index: 2
Last. Wei Wei (Anhui Medical University)H-Index: 73
view all 8 authors...
Deficiency of G protein-coupled receptor kinase 2 (GRK2) was found to protect mice from dextran sulfate sodium (DSS)-induced colitis. Paeoniflorin-6'-O-benzene sulfonate (CP-25) has been shown to exert anti-inflammatory immune regulatory effects in animal models of inflammatory autoimmune disease. This study aimed to investigate the of GRK2 in the pathogenesis of ulcerative colitis (UC) and its effects on macrophage polarization, macrophage subtype regulation of intestinal barrier function, and ...
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#1Jhonatan Basso Lino (FIOCRUZ: Oswaldo Cruz Foundation)
#2Anny Waloski Robert (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 6
Last. Alessandra Melo de Aguiar (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 11
view all 4 authors...
The secretome of different cell types has been applied on in vitro and in vivo assays, indicating considerable therapeutic potential. However, the choice of the ideal cell type and culture conditions for obtaining the best set of soluble factors, as well as the assays to assess specific effects, remain subjects of vigorous debate. In this study, we used mass spectrometry to characterize the secretomes of ventricle derived-cardiac resident stromal cells (vCRSC) and human dermal fibroblasts (HDFs)...
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#1Chun-Jung Chang (TMU: Taipei Medical University)
#2Chiou Feng Lin (TMU: Taipei Medical University)H-Index: 54
Last. Chia Ling Chen (TMU: Taipei Medical University)H-Index: 30
view all 5 authors...
Chronic respiratory diseases (CRDs), including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), lung cancer, and asthma, are significant global health problems due to their prevalence and rising incidence. The roles of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in controlling tyrosine phosphorylation of targeting proteins modulate multiple physiological cellular responses and contribute to the pathogenesis of CRDs. Src homology-2 domain-containing P...
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#1Piero Leone (University of Bari)H-Index: 6
#2Maria Tolomeo (University of Bari)H-Index: 4
Last. Maria Barile (University of Bari)H-Index: 35
view all 8 authors...
Riboflavin (Rf), or vitamin B2, is the precursor of FMN and FAD, redox cofactors of several dehydrogenases involved in energy metabolism, redox balance and other cell regulatory processes. FAD synthase, coded by FLAD1 gene in humans, is the last enzyme in the pathway converting Rf into FAD. Mutations in FLAD1 gene are responsible for neuromuscular disorders, in some cases treatable with Rf. In order to mimic these disorders, the Caenorhabditis elegans (C. elegans) gene orthologue of FLAD1 (flad-...
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#1Liping Wang (DUT: Dalian University of Technology)H-Index: 2
#2Xixi Chen (DUT: Dalian University of Technology)H-Index: 7
Last. Jianing Zhang (DUT: Dalian University of Technology)H-Index: 9
view all 7 authors...
Abnormal sialylation is a distinctive feature of human hepatocellular carcinoma (HCC) and is closely related to its malignant properties. Exosomes have characteristic protein and lipid composition; however, the results concerning glycoprotein composition and glycosylation are scarce. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified multiple microvesicle-related sialylated proteins including CD63, a classic marker of exosomes. The silencing of α2,6-sialyltransfe...
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#1Shu Wen Wan (NCKU: National Cheng Kung University)H-Index: 17
#2Ying-Ray Lee (KMU: Kaohsiung Medical University)
Last. Chih Peng Chang (NCKU: National Cheng Kung University)H-Index: 24
view all 4 authors...
Autophagy is not only an intracellular recycling degradation system that maintains cellular homeostasis but is also a component of innate immunity that contributes to host defense against viral infection. The viral components as well as viral particles trapped in autophagosomes can be delivered to lysosomes for degradation. Abundant evidence indicates that dengue virus (DENV) has evolved the potent ability to hijack or subvert autophagy process for escaping host immunity and promoting viral repl...
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#1Xiangui Meng (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Hongwei Yuan (HUST: Huazhong University of Science and Technology)
Last. Xiaoping Zhang (HUST: Huazhong University of Science and Technology)H-Index: 18
view all 7 authors...
Prostate cancer (PCa), characterized by high invasion, metastasis, and recurrence, is the most prevalent malignant tumor in men worldwide. A clear understanding of the underlying molecular mechanisms and their role during PCa tumorigenesis can help develop prognostic and targeted therapies. We analyzed datasets from public databases, including the Cancer Genome Atlas (TCGA) and Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) for differential expression of solute carrier famil...
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#1Ramin Hosseinzadeh (Tehran University of Medical Sciences)H-Index: 5
Last. Hamed MohammadiH-Index: 23
view all 10 authors...
Immune checkpoint blockade therapy (ICBT) has become a successful cancer treatment approach in the field of cancer immunotherapy. Blockade of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) with monoclonal antibodies have been known as successful examples of cancer immunotherapy in recent years. Although ICBT has been shown to be beneficial in cancers, such benefits have only been seen in a portion of cancer patients. In this regard, enhancing the therapeutic effects of inhibitin...
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#1Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 24
#2Chulwon Kim (Kyung Hee University)H-Index: 27
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 50
view all 10 authors...
STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that are connected with cell proliferation, antiapoptosis, metastasis, angiogenesis, and immune evasion in tumor cells. In this study, we investigated the effect of crocetin on the growth of HCC cells and dissected its underlying molecular mechanism in imparting a cytotoxic effect. Crocetin suppressed proliferation, promoted...
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