PLOS Medicine
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#1Sean Harrison (UoB: University of Bristol)H-Index: 12
#2Padraig Dixon (UoB: University of Bristol)H-Index: 9
Last. Neil M. Davies (NTNU: Norwegian University of Science and Technology)
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BACKGROUND The prevalence of obesity has increased in the United Kingdom, and reliably measuring the impact on quality of life and the total healthcare cost from obesity is key to informing the cost-effectiveness of interventions that target obesity, and determining healthcare funding. Current methods for estimating cost-effectiveness of interventions for obesity may be subject to confounding and reverse causation. The aim of this study is to apply a new approach using mendelian randomisation fo...
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#1Jiaxi Zhao (Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Hao Wang (Chinese PLA General Hospital)H-Index: 6
Last. Chung-Wah Siu (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 60
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BACKGROUND Adherence to oral anticoagulant therapy in patients with atrial fibrillation (AF) in China is low. Patient preference, one of the main reasons for discontinuation of oral anticoagulant therapy, is an unfamiliar concept in China. METHODS AND FINDINGS A discrete choice experiment (DCE) was conducted to quantify patient preference on 7 attributes of oral anticoagulant therapy: antidote (yes/no), food-drug interaction (yes/no), frequency of blood monitoring (no need, every 6/3/1 month[s])...
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#1Sanjay K. Mohanty (International Institute for Population Sciences)H-Index: 27
#2Sarang Pedgaonkar (International Institute for Population Sciences)H-Index: 3
Last. Owen O'Donnell (EUR: Erasmus University Rotterdam)H-Index: 48
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Background Lack of nationwide evidence on awareness, treatment, and control (ATC) of hypertension among older adults in India impeded targeted management of this condition. We aimed to estimate rates of hypertension ATC in the older population and to assess differences in these rates across sociodemographic groups and states in India. null null Methods and findings We used a nationally representative survey of individuals aged 45 years and over and their spouses in all Indian states (except one)...
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#1Stefan Gutwinski (Humboldt University of Berlin)H-Index: 4
#2Stefanie Schreiter (Humboldt University of Berlin)H-Index: 7
Last. Seena Fazel (University of Oxford)H-Index: 79
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Background Homelessness continues to be a pressing public health concern in many countries, and mental disorders in homeless persons contribute to their high rates of morbidity and mortality. Many primary studies have estimated prevalence rates for mental disorders in homeless individuals. We conducted a systematic review and meta-analysis of studies on the prevalence of any mental disorder and major psychiatric diagnoses in clearly defined homeless populations in any high-income country. null n...
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#1K. Miriam Elfström (Karolinska University Hospital)H-Index: 3
#2Carina Eklund (Karolinska University Hospital)H-Index: 24
Last. Joakim Dillner (Karolinska University Hospital)H-Index: 105
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BACKGROUND Clinical trials in the research setting have demonstrated that primary human papillomavirus (HPV)-based screening results in greater protection against cervical cancer compared with cytology, but evidence from real-life implementation was missing. To evaluate the effectiveness of HPV-based cervical screening within a real-life screening program, the organized, population-based cervical screening program in the capital region of Sweden offered either HPV- or cytology-based screening in...
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#1Justine Davies (University of Birmingham)H-Index: 26
#2Adrian W. Gelb (UCSF: University of California, San Francisco)H-Index: 64
Last. Kathryn M. Chu (Stellenbosch University)H-Index: 6
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Background null Indicators to evaluate progress towards timely access to safe surgical, anaesthesia, and obstetric (SAO) care were proposed in 2015 by the Lancet Commission on Global Surgery. These aimed to capture access to surgery, surgical workforce, surgical volume, perioperative mortality rate, and catastrophic and impoverishing financial consequences of surgery. Despite being rapidly taken up by practitioners, data points from which to derive the indicators were not defined, limiting compa...
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#1Lukas E Brümmer (University Hospital Heidelberg)
#2Stephan Katzenschlager (University Hospital Heidelberg)
Last. Nira R. Pollock (Boston Children's Hospital)H-Index: 22
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Background SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs) are increasingly being integrated in testing strategies around the world. Studies of the Ag-RDTs have shown variable performance. In this systematic review and meta-analysis, we assessed the clinical accuracy (sensitivity and specificity) of commercially available Ag-RDTs. null null Methods and findings We registered the review on PROSPERO (registration number: CRD42020225140). We systematically searched multiple databases (PubMed, W...
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#1Sheila Isanaka (Harvard University)H-Index: 18
#2Souna GarbaH-Index: 1
Last. Rebecca F. GraisH-Index: 50
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Background Nutritional status may play a role in infant immune development. To identify potential boosters of immunogenicity in low-income countries where oral vaccine efficacy is low, we tested the effect of prenatal nutritional supplementation on immune response to 3 doses of a live oral rotavirus vaccine. null null Methods and findings We nested a cluster randomized trial within a double-blind, placebo-controlled randomized efficacy trial to assess the effect of 3 prenatal nutritional supplem...
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#1Julie E Bines (University of Melbourne)H-Index: 36
Julie Bines discusses an accompanying study by Sheila Isanaka and colleagues on nutrient supplementation and immune responses to rotavirus vaccination.
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#1Florian Naudet (University of Rennes)H-Index: 17
#2Maximilian Siebert (University of Rennes)H-Index: 1
Last. Erick H. Turner (OHSU: Oregon Health & Science University)H-Index: 38
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Florian Naudet and co-authors propose a pathway involving registered criteria for evaluation and approval of new drugs.
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