Endocrine-related Cancer
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#1Li Qin (BCM: Baylor College of Medicine)H-Index: 17
#2Jianwei Chen (BCM: Baylor College of Medicine)H-Index: 18
Last. Jin Wang (BCM: Baylor College of Medicine)H-Index: 26
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Steroid receptor coactivators (SRCs) possess specific and distinct oncogenic roles in the initiation of cancer and in its progression to a more aggressive disease. These coactivators interact with nuclear receptors and other transcription factors to boost transcription of multiple genes, which potentiate cancer cell proliferation, migration, invasion, tumor angiogenesis and epithelial-mesenchymal transition (EMT). Targeting SRCs using small molecule inhibitors (SMIs) is a promising approach to c...
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#1Jonathan Fussey (RD&E: Royal Devon and Exeter Hospital)H-Index: 4
#2Robin N Beaumont (University of Exeter)H-Index: 27
Last. Jessica Tyrrell (University of Exeter)H-Index: 34
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#1Gustavo Penna (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
#2Ileana Gabriela Sanchez Rubio (UNIFESP: Federal University of São Paulo)H-Index: 5
Last. Helton Estrela Ramos (UFBA: Federal University of Bahia)H-Index: 11
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Neuroendocrine neoplasms (NENs) represent a rare and heterogeneous group of malignancies, sharing features of both neural and endocrine cells. NENs G3 appear as a highly aggressive subset with poor prognosis and limited therapeutic options. The small-molecule inhibitor of the WEE1 tyrosine kinase, adavosertib (AZD1775), has previously demonstrated potent anti-tumor effects on various types of cancer in preclinical and clinical studies. However, the role of adavosertib in NENs G3 had remained elu...
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#1Ville Paakinaho (University of Eastern Finland)H-Index: 13
#2Jorma J. Palvimo (University of Eastern Finland)H-Index: 65
Steroid receptors (SRs) constitute an important class of signal-dependent transcription factors (TFs). They regulate a variety of key biological processes and are crucial drug targets in many disease states. In particular, estrogen (ER) and androgen receptors (AR) drive the development and progression of breast and prostate cancer, respectively. Thus, they represent the main specific drug targets in these diseases. Recent evidence has suggested that the crosstalk between signal-dependent TFs is ...
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#1Alyaksandr V. Nikitski (University of Pittsburgh)H-Index: 9
#2Marina N. Nikiforova (University of Pittsburgh)H-Index: 55
Last. Yuri E. Nikiforov (University of Pittsburgh)H-Index: 90
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Mutations of the TP53 tumor suppressor gene are highly prevalent in thyroid anaplastic carcinomas (AC) but are also reported in some well-differentiated cancers and even benign adenomas. The natural history of TP53-mutant adenomas, and whether they may represent a precursor for well-differentiated cancer or AC is largely unknown. Similarly, the frequency of TP53 mutations in thyroid nodules found on routine molecular analysis of fine-needle aspiration (FNA) samples is not established. A database...
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#1Nikita Pozdeyev (University of Colorado Denver)H-Index: 21
#2Lauren Fishbein (University of Colorado Denver)H-Index: 18
Last. Lindsey J Foust (University of Colorado Denver)
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Despite recent advances in elucidating molecular pathways underlying adrenocortical carcinoma (ACC), this orphan malignancy is associated with poor survival. Identification of targetable genomic alterations is critical to improve outcomes. The objective of this study was to characterize the genomic profile of a large cohort of patient ACC samples to identify actionable genomic alterations. Three hundred sixty-four individual patient ACC tumors were analyzed. The median age of the cohort was 52 y...
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#1Alexa Childs (UCL: University College London)H-Index: 6
#2Christopher D. Steele (UCL: University College London)H-Index: 8
Last. Lucia Conde (UCL: University College London)H-Index: 30
view all 17 authors...
Single-cell profiling of circulating tumor cells (CTCs) as part of a minimally invasive liquid biopsy presents an opportunity to characterize and monitor tumor heterogeneity and evolution in individual patients. In this study, we aimed to compare single-cell copy number variation (CNV) data with tissue, and define the degree of intra- and inter-patient genomic heterogeneity. We performed next generation sequencing (NGS) whole genome CNV analysis of 125 single CTCs derived from seven patients wit...
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#1Amina Zoubeidi (UBC: University of British Columbia)H-Index: 47
#2Paramita M. Ghosh (VA: United States Department of Veterans Affairs)H-Index: 29
In this special issue of Endocrine-Related Cancer, we are celebrating the 80th anniversary of hormone ablation as treatment for metastatic prostate cancer. Our understanding has evolved from the observation that androgen withdrawal, either surgical or pharmacological, resulted in prostatic atrophy in animal models, to its application in patients, to investigation of the mysterious way in which prostate cancer escapes androgen dependence. We are now in an era of novel AR pathway inhibitors, combi...
1 CitationsSource
#1Eilon Krashin (TAU: Tel Aviv University)H-Index: 2
#2Barbara Silverman (Sheba Medical Center)H-Index: 2
Last. Osnat Ashur-Fabian (TAU: Tel Aviv University)H-Index: 21
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Research on the association between thyroid hormone levels and cancer mortality remains limited and inconclusive. We determined the relation of thyroid stimulating hormone (TSH), free T4 (FT4) and free T3 (FT3) levels with mortality in overall cancer and specific tumor types. Thyroid hormone levels one to five years prior to cancer diagnosis, as well as multiple clinical and demographic parameters, were retrospectively collected for 10,325 Israeli cancer patients, diagnosed between 2000 and 2016...
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Cancer
Endocrinology
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Breast cancer
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