International Journal of Molecular Medicine
Papers 7,842
1 page of 785 pages (7,842 results)
#1Patrizia Virdis (UniSS: University of Sassari)H-Index: 13
#2Rossana Migheli (UniSS: University of Sassari)H-Index: 27
Last. Luigi Bagella (UniSS: University of Sassari)H-Index: 27
view all 13 authors...
Multiple myeloma (MM) is an aggressive B cell malignancy. Substantial progress has been made in the therapeutic context for patients with MM, however it still represents an incurable disease due to drug resistance and recurrence. Development of more effective or synergistic therapeutic approaches undoubtedly represents an unmet clinical need. Tomentosin is a bioactive natural sesquiterpene lactone extracted by various plants with therapeutic properties, including anti‑neoplastic effects. In the ...
#1Yinghui WangH-Index: 2
#2Qiuju MouH-Index: 1
Last. Lili ZhuH-Index: 1
view all 5 authors...
The aim of the present study was to investigate whether long non‑coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) could modulate activation and inflammation of hepatic stellate cell (HSCs) via regulation of a microRNA (miR)‑181a‑toll like receptor (TLR)4/nuclear factor (NF)‑κB axis, thereby contributing to the development of liver fibrosis. A total of 151 patients with liver fibrosis were recruited, and the serum levels of alanine transaminase, aspartate aminotransferas...
#1Linhai Zhu (ZJU: Zhejiang University)H-Index: 5
#2Ying Wang (ZJU: Zhejiang University)H-Index: 2
Last. Jian Hu (ZJU: Zhejiang University)H-Index: 19
view all 7 authors...
Schizandrin A (SchA) can be extracted from the vine plant Schisandra chinensis and has been reported to confer various biologically active properties. However, its potential biological effects on non‑small cell lung cancer (NSCLC) remain unknown. Therefore, the present study aims to address this issue. NSCLC and normal lung epithelial cell lines were first treated with SchA. Cell viability and proliferation were measured using CellTiter‑Glo Assay and colony formation assays, respectively. PI sta...
#1Da-Won Choi (Ewha Womans University)
#2Kyung-Ah Cho (Ewha Womans University)H-Index: 4
Last. So-Youn Woo (Ewha Womans University)H-Index: 26
view all 7 authors...
Mesenchymal stem cells (MSCs) are mesoderm‑originated adult SCs that possess multidirectional differentiation potential. MSCs migrate to injured tissue and secrete a range of paracrine factors that induce regeneration in damaged tissue and exert immune modulation. Because tumor progression is dependent on cross‑talk between the tumor and its microenvironment, MSCs also produce extracellular vesicles (EVs) that mediate information transfer in the tumor microenvironment. However, the effect of MSC...
#1Limin Sun (Soochow University)
#2Xin HeH-Index: 1
Last. Guizhou Tao (Soochow University)
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Mesenchymal stem cell (MSC) therapy has potential applications in treating atherosclerosis and coronary heart disease (CAD). Previous studies have demonstrated that MSCs are the most preferable sources of therapeutic exosomes, which carry long non‑coding RNAs and participate in the progression of atherosclerosis. The results of our previous bioinformatics study demonstrated that the levels of LOC100129516 were significantly upregulated in peripheral blood mononuclear cells obtained from patients...
#1Niki Mourtzi (National and Kapodistrian University of Athens)H-Index: 4
#2Tania Siahanidou (National and Kapodistrian University of Athens)H-Index: 15
Last. George E. Baltatzis (National and Kapodistrian University of Athens)H-Index: 6
view all 13 authors...
Breast milk is the ideal food for infants and undoubtedly has immediate and long‑term benefits. Breast milk contains extracellular vesicles (EVs) i.e., exosomes secreted by maternal breast cells. Exosomes carry genetic material, such as long non‑coding RNAs (lncRNAs), which possibly participate in cell‑to‑cell communications, as they are known to regulate critical gene pathways. The aim of the present study was to screen human breastmilk exosomes for their lncRNA cargo and to examine exosomal ln...
#1Chun-Min Kang (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 3
#2Weikang Li (GZUCM: Guangzhou University of Chinese Medicine)
Last. Heng Wang (GZUCM: Guangzhou University of Chinese Medicine)
view all 14 authors...
Atherosclerosis and related cardiovascular diseases pose severe threats to human health worldwide. There is evidence to suggest that at least 50% of foam cells in atheromas are derived from vascular smooth muscle cells (VSMCs); the first step in this process involves migration to human atherosclerotic lesions. Long non‑coding RNAs (lncRNAs) have been found to play significant roles in diverse biological processes. The present study aimed to investigate the role of lncRNAs in VSMCs. The expressio...
#1Lei WangH-Index: 1
#2Jiangwei DingH-Index: 1
Last. Feng Wang (ZJU: Zhejiang University)H-Index: 3
view all 11 authors...
Epilepsy comorbidities and anti‑epileptic drugs (AEDs) are currently the main limitations of epilepsy treatment. Semaglutide is a glucagon like peptide‑1 analogue that has entered the market as a new once‑weekly drug for type II diabetes. The aim of the present study was to investigate the functions of semaglutide in epilepsy and inflammation models, in order to investigate its potential mechanism. In vitro, an inflammation model was established using lipopolysaccharide (LPS) and nigericin stimu...
#1Maoquan Li (Sun Yat-sen University)
#2Jinqiu Ning (Sun Yat-sen University)
Last. Xiaoshi Jia (Sun Yat-sen University)
view all 6 authors...
Chondrocytes are well adapted to hypoxia and produce more functional extracellular matrix in low oxygen environments in vitro. In our previous study, methyltransferase SET domain containing (SETD)7 regulated chondrocyte activity in hypoxic conditions. However, the precise association between SETD7 and chondrocyte differentiation under low oxygen partial pressure remains unclear. The association between SETD7 and chondrocyte differentiation was studied by silencing SETD7 in chondrocytes in vitro....
Lung cancer is the second most frequent cancer type in both men and women, and it is considered to be one of the major causes of cancer‑related mortality worldwide. However, few biomarkers are currently available for the diagnosis of lung cancer. The aim of the present study was to investigate the function of the immunoglobulin superfamily containing leucine‑rich repeat (ISLR) gene in non‑small cell lung cancer (NSCLC) cells, and to elucidate the underlying molecular mechanism of its action. The...
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