International Journal of Molecular Medicine
Papers 7809
1 page of 781 pages (7,809 results)
#1Yun Xu (CSU: Central South University)
#2Yi Li (CSU: Central South University)H-Index: 14
Severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2) is the virus that causes coronavirus disease 2019. Angiotensin­converting enzyme 2 (ACE2) is the SARS­CoV binding site and is ubiquitously expressed in endothelial cells of several organs, with the highest levels in the cardiovascular system, kidney and lungs. A disintegrin and metalloproteinase 17 (ADAM17) is involved in ectodomain shedding of ACE2. In the present study, reverse­transcription­quantitative PCR, transfection, TUNNEL ass...
#1Yunlong Huang (Anhui Medical University)H-Index: 3
#2Ran Ruan (Anhui Medical University)
Last. Wei He (Anhui Medical University)H-Index: 1
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Growth factor‑independent 1 (GFI1) has been reported to serve a vital role in hematopoietic development. However, the function and molecular mechanism of GFI1 in esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, the biological functions and the molecular mechanism of the effects of GFI1 in ESCC were analyzed. The results demonstrated that GFI1 expression levels were significantly upregulated in ESCC compared with those in normal esophageal tissues. Knockdown of GFI...
#1Yan Li (Henan University)H-Index: 2
#2Li-Ling Xiang (Henan University)H-Index: 1
Last. Can Wang (Henan University)H-Index: 1
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Ischemic stroke is one of the most common causes of mortality worldwide and is a primary cause of disability and mortality in adults. There is an unmet need for drugs that can effectively treat ischemic stroke. Hence, the present study explored the neuroprotective effects of andrographolide (Andro) in a mouse model of bilateral common carotid artery occlusion, and systematically evaluated the potential mechanisms underlying its effects. The effects of Andro on mouse brain tissue following cerebr...
#2Huadong Li (HUST: Huazhong University of Science and Technology)
Last. Weihua Bian (Binzhou University)
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Heme oxygenase‑1 (HO‑1) has been reported to be upregulated following renal ischemia‑reperfusion injury (IRI) and plays a key cytoprotective role; however, the underlying molecular mechanisms of its protective effects remain poorly understood. In the present study, in order to further elucidate the molecular mechanisms underlying the cytoprotective role of HO‑1 in renal IRI, HO‑1+/+ and HO‑1+/‑ mice were subjected to renal ischemia and subsequent reperfusion followed by the analysis of blood ure...
#1Shenglin Xian (Guangxi Medical University)H-Index: 1
#2Ang Chen (Guangxi Medical University)H-Index: 2
Last. Zhiyu Zeng (Guangxi Medical University)H-Index: 7
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Rheumatic heart disease (RHD) affects numerous individuals annually; however, its pathogenesis remains unclear. The sphingosine 1‑phosphate receptor 1 (S1PR1) and signal transducer and activator of transcription 3 (STAT3) have recently been shown to be involved in valvular damage via the promotion of the differentiation of T helper 17 (Th17) cells during the development of RHD‑induced valvular damage. The present study investigated whether altering the expression of S1PR1 or STAT3 attenuates val...
Dysbiosis, a qualitative and quantitative aberrancy of gut microbiota, has attracted marked attention. At present, advances in molecular biological techniques have made it possible to analyze gut microbiota at the DNA and RNA levels without culturing, and methods such as 16S ribosomal RNA targeting analysis and metagenomic analysis using next‑generation sequencers have been developed. The relationship between gut microbiota and various diseases has been extensively examined. Gut microbiota are e...
#1Jing Zhao (Anhui Medical University)
#2Juan Chen (Anhui Medical University)
Last. Yong-Gui Wu (Anhui Medical University)H-Index: 3
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It has been previously reported that macrophages may be involved in diabetic nephropathy (DN) development. Furthermore, Bruton's tyrosine kinase (BTK) may participate in macrophage activation and lead to the release of inflammatory mediators. The main aim of the present study was to analyze the association between renal BTK expression and clinical indicators. Moreover, BTK knockout mice were used to establish a diabetic model for further research. The results demonstrated that BTK was activated ...
#1Shun Yao (Zunyi Medical College)
#2Xingyue Yang (Zunyi Medical College)
Last. Biguang Tuo (Zunyi Medical College)H-Index: 21
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Ischemic stroke is a leading cause of mortality and disability. Diabetes mellitus, characterized by hyperglycemia, is a common concomitant disease of ischemic stroke, which is associated with autophagy dysfunction and blood‑brain barrier (BBB) damage following cerebral ischemia/reperfusion (I/R) injury. At present, there is no effective treatment strategy for the disease. The purpose of the present study was to explore the molecular mechanisms underlying the protective effects of selenium on the...
#1Jing-Meng Hu (Southern Medical University)
#2Lijie He (Fourth Military Medical University)H-Index: 14
Last. Li Liang (Southern Medical University)
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Top fields of study
Molecular biology
Cell cycle
Cancer research
Molecular medicine