International Journal of Molecular Medicine
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Papers 7721
1 page of 773 pages (7,721 results)
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#1Jian Yang (JLU: Jilin University)
#2Xiao Miao (JLU: Jilin University)
Last. Guanfang Su (JLU: Jilin University)H-Index: 10
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Diabetic retinopathy (DR) is a type of retinal microangiopathy caused by diabetes mellitus. It has become the leading cause of blindness among working individuals worldwide. DR is becoming increasingly common among younger diabetic patients and there is a need for lifelong treatment. The pathogenic mechanisms of DR are influenced by a number of factors, such as hyperglycemia, hyperlipidemia, inflammatory response and oxidative stress, among others. Currently, the treatment methods for DR mainly ...
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Circular nuclear receptor interacting protein 1 (circNRIP1) is implicated in tumor initiation and progression; however, the underlying mechanism of keloid progression is unclear. To the best of our knowledge, the present study is the first to characterize the contribution of circNRIP1 to keloid progression and evaluate the potential underlying molecular mechanisms using keloid‑derived fibroblasts. The expression profile of circNRIP1 was confirmed in keloid tissue. The contribution of circNRIP1 t...
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#1Xiaofeng Lu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Shaoling Yu (HUST: Huazhong University of Science and Technology)H-Index: 6
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 13
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Bone‑related diseases comprise a large group of common diseases, including fractures, osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly the elderly. The progressive destruction and loss of alveolar bone caused by periodontitis is a specific type of bone loss, which has a high incidence and markedly reduces the quality of life of patients. With the existing methods of prevention and treatment, the incidence and mortality of bone‑related diseases are st...
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#1Shan Cai (Kunming Medical University)
#2Chao-jia Shi (Kunming Medical University)H-Index: 1
Last. Xiang-peng Wang (Kunming Medical University)H-Index: 1
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The mortality rate of patients with glioma is increasing worldwide per annum. This is attributed to the poor disease prognosis, most notably for high‑grade gliomas (grade III and IV), which does not improve the overall patient survival. The dysregulation of microRNA (miRNA/miR)‑124‑3p is found in a variety of tumors. However, the association between miR‑124‑3p expression and its target genes in glioma has not been thoroughly elucidated. The present study aimed to explore the possible effects of ...
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#1Yuguang Zhu (WMU: Weifang Medical University)
#2Fengqin Hao (WMU: Weifang Medical University)
A number of studies have verified the vital effects of long non‑coding RNAs on the malignant behaviour of retinoblastoma (RB). The objective of the present study was to examine the specific role and mechanisms of HLA complex P5 (HCP5) in RB. For this purpose, reverse transcription‑quantitative polymerase chain reaction was used to determine the expression of HCP5, microRNA (miRNA/miR)‑3619‑5p and histone deacetylase 9 (HDAC9). A 3‑(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2‑H-tetrazolium bromide a...
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#1Xun Wang (Dalian Medical University)
#2Shuang Zou (ZJU: Zhejiang University)
Last. Li-Jun Zhang (Dalian Medical University)
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Glioblastoma (GBM) is the most common aggressive brain tumor and is associated with an extremely poor prognosis, as the current standard of care treatments have limited efficacy. Natural compounds have attracted increasing attention as potential anticancer drugs. Alantolactone (ATL) is a natural small molecule inhibitor, that has antitumor properties. In the present study, U87MG and U251 cells were treated ATL and changes in actin/G‑actin/F‑actin/cofilin pathway were detected in whole cells, in ...
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#1Junmin Wang (SHU: Shanghai University)
#2Hongjiao Xiang (SHU: Shanghai University)H-Index: 1
Last. Tao Wu (SHU: Shanghai University)H-Index: 14
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The appearance and growth of malignant tumors is a complicated process that is regulated by a number of genes. In recent years, studies have revealed that the transforming growth factor‑β (TGF‑β) signaling pathway serves an important role in cell cycle regulation, growth and development, differentiation, extracellular matrix synthesis and immune response. Notably, two members of the TGF‑β signaling pathway, TGF‑β1 and TGF‑β receptor 1 (TGF‑βR1), are highly expressed in a variety of tumors, such ...
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#1Libin Tian (WHU: Wuhan University)
#2Feng Han (HUST: Huazhong University of Science and Technology)
Last. Lili Chen
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As previously reported, long intergenic non‑protein‑coding RNA 1006 (LINC01006) plays crucial roles in prostate, pancreatic and gastric cancers. However, whether it plays important roles in cervical cancer remains unclear. The present study thus aimed to determine the precise role of LINC01006 in cervical cancer and elucidate its regulatory mechanisms. The expression of LINC01006 in cervical cancer was examined by reverse transcription‑quantitative polymerase chain reaction. Cell proliferation a...
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Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19). This disease is characterized by a respiratory syndrome that can progress to an acute respiratory distress syndrome. To date, limited effective therapies are available for the prevention or treatment of COVID‑19; therefore, it is necessary to propose novel treatment options with immunomodulatory effects. Vitamin D serves functions in bone ...
2 CitationsSource
#1Yunhe Qu (Northeast Normal University)H-Index: 4
#2Xiaolin Zhao (Northeast Normal University)
Last. Lin Sun (Northeast Normal University)H-Index: 13
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The present study was designed to investigate the structure and immunomodulatory activity of a polysaccharide. A novel acidic β‑glucan (WCCP‑A‑b; molecular weight, 7.3 kDa) was purified from the fruiting bodies of the edible mushroom Cantharellus cibarius, which possesses high nutritional values. WCCP‑A‑b was composed primarily of glucose (89.7%) and glucuronic acid (8.8%). Methylation and nuclear magnetic resonance analysis suggested that WCCP‑A‑b contained β‑D‑1,6‑glucan as its main chain, whi...
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