Health Technology Assessment
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#1David J Beard (University of Oxford)H-Index: 64
#2Marion K Campbell (Aberd.: University of Aberdeen)H-Index: 70
Last. Jonathan Pugh (University of Oxford)H-Index: 9
view all 31 authors...
BACKGROUND The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges. OBJECTIVES To provide a summary of knowledge on placebo controls in surgical trials and to summarise any recommendations for designers, evaluators and funders of placebo-controlled surgical trials. DESIGN To carry ...
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#1Ana Duarte (Ebor: University of York)H-Index: 8
#2Alexis Llewellyn (Ebor: University of York)H-Index: 12
Last. Mark Simmonds (Ebor: University of York)H-Index: 25
view all 8 authors...
Background null QAngio® XA 3D/QFR® (three-dimensional/quantitative flow ratio) imaging software (Medis Medical Imaging Systems BV, Leiden, the Netherlands) and CAAS® vFFR® (vessel fractional flow reserve) imaging software (Pie Medical Imaging BV, Maastricht, the Netherlands) are non-invasive technologies to assess the functional significance of coronary stenoses, which can be alternatives to invasive fractional flow reserve assessment. null Objectives null The objectives were to determine the cl...
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#1Sarah J. Stock (Edin.: University of Edinburgh)H-Index: 25
#2Margaret Horne (Edin.: University of Edinburgh)H-Index: 4
Last. Jon Dorling (Halifax)H-Index: 20
view all 24 authors...
BACKGROUND The diagnosis of preterm labour is challenging. False-positive diagnoses are common and result in unnecessary, potentially harmful treatments (e.g. tocolytics, antenatal corticosteroids and magnesium sulphate) and costly hospital admissions. Measurement of fetal fibronectin in vaginal fluid is a biochemical test that can indicate impending preterm birth. OBJECTIVES To develop an externally validated prognostic model using quantitative fetal fibronectin concentration, in combination wi...
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#1David P. French (University of Manchester)H-Index: 53
#2Lisa M. Miles (University of Manchester)H-Index: 9
Last. Jim McCambridge (Ebor: University of York)H-Index: 59
view all 8 authors...
BACKGROUND Measurement can affect the people being measured; for example, asking people to complete a questionnaire can result in changes in behaviour (the 'question-behaviour effect'). The usual methods of conduct and analysis of randomised controlled trials implicitly assume that the taking of measurements has no effect on research participants. Changes in measured behaviour and other outcomes due to measurement reactivity may therefore introduce bias in otherwise well-conducted randomised con...
1 CitationsSource
#1Rebecca L. Gould (UCL: University College London)H-Index: 18
#2Julie Loebach Wetherell (UCSD: University of California, San Diego)H-Index: 55
Last. Marie Le Novere (UCL: University College London)
view all 11 authors...
BACKGROUND Generalised anxiety disorder, characterised by excessive anxiety and worry, is the most common anxiety disorder among older people. It is a condition that may persist for decades and is associated with numerous negative outcomes. Front-line treatments include pharmacological and psychological therapy, but many older people do not find these treatments effective. Guidance on managing treatment-resistant generalised anxiety disorder in older people is lacking. OBJECTIVES To assess wheth...
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#1Sally Hopewell (University of Oxford)H-Index: 61
#2David J Keene (University of Oxford)H-Index: 11
Last. Willie Hamilton (University of Exeter)H-Index: 17
view all 16 authors...
BACKGROUND Rotator cuff-related shoulder pain is very common, but there is uncertainty regarding which modes of exercise delivery are optimal and the long-term benefits of corticosteroid injections. OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of progressive exercise compared with best-practice physiotherapy advice, with or without corticosteroid injection, in adults with a rotator cuff disorder. DESIGN This was a pragmatic multicentre superiority randomised controlled ...
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#1Christopher Gidlow (Staffordshire University)H-Index: 28
#2Naomi Ellis (Staffordshire University)H-Index: 14
Last. David Clark-Carter (Staffordshire University)H-Index: 21
view all 0 authors...
Background The NHS Health Check is a national cardiovascular disease prevention programme. There is a lack of evidence on how health checks are conducted, how cardiovascular disease risk is communicated to foster risk-reducing intentions or behaviour, and the impact on communication of using different cardiovascular disease risk calculators. Objectives RIsk COmmunication in Health Check (RICO) study aimed to explore practitioner and patient understanding of cardiovascular disease risk, the assoc...
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#1Amanda Daley (Lboro: Loughborough University)H-Index: 49
#2Kate Jolly (University of Birmingham)H-Index: 49
Last. Hannah Bensoussane (University of Birmingham)
view all 13 authors...
BACKGROUND Pregnancy is a high-risk time for excessive weight gain. The rising prevalence of obesity in women, combined with excess weight gain during pregnancy, means that there are more women with obesity in the postnatal period. This can have adverse health consequences for women in later life and increases the health risks during subsequent pregnancies. OBJECTIVE The primary aim was to produce evidence of whether or not a Phase III trial of a brief weight management intervention, in which po...
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#1Kevin Wing (Lond: University of London)H-Index: 13
#2Elizabeth A. Williamson (Lond: University of London)H-Index: 73
Last. Ian J. Douglas (Lond: University of London)H-Index: 38
view all 8 authors...
Background null Chronic obstructive pulmonary disease treatment is informed by randomised controlled trial results, but it is unclear if these findings apply to people excluded from these trials. We used data from the TORCH (TOwards a Revolution in COPD Health) randomised controlled trial to validate non-interventional methods for assessing the clinical effectiveness of chronic obstructive pulmonary disease treatment in the UK Clinical Practice Research Datalink, before applying these methods to...
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#1Jane E. Norman (UoB: University of Bristol)H-Index: 67
#2John Norrie (Edin.: University of Edinburgh)H-Index: 69
Last. Joel Smith (University of Oxford)H-Index: 6
view all 18 authors...
BACKGROUND Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm birth and prevents neonatal morbidity. OBJECTIVE STOPPIT 2 aimed to evaluate the clinical utility of the Arabin cervical pessary in preventing preterm birth i...
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Top fields of study
Randomized controlled trial
Intensive care medicine
Physical therapy
Psychological intervention
Cost effectiveness
Medicine