Objectives null To assess the feasibility and uptake of a community based prostate cancer (PrCa) screening programme selecting men according to their genetic risk of PrCa. To assess the uptake of PrCa screening investigations by men invited for screening. The uptake of the pilot study would guide the opening of the larger BARCODE1 study recruiting 5000 men. null Subjects and methods null Healthy males aged 55-69 years were invited to participate via their General Practitioners (GPs). Saliva samp...
Last. Olof Akre(KI: Karolinska Institutet)H-Index: 45
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OBJECTIVE To investigate the cause-specific mortality in the postoperative period after radical prostatectomy (RP) for prostate cancer (PCa). METHODS In the National Prostate Cancer Register of Sweden (NPCR), we identified all men who died within 90 days after RP performed 1998-2018 and we assessed cause of death in a chart review. We compared the adjudications of death from our medical record review with those in in The Swedish Cause of Death Registry (CDR). RESULTS Out of 44 635, 58 (0.13%) me...
#1Roy Mano(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 17
#2Amy Tin(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 9
Last. Jonathan A. Coleman(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 51
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OBJECTIVES To evaluate the association between intraoperative anesthetic parameters, primarily intraoperative hypotension, and postoperative renal function in patients undergoing nephrectomy. PATIENTS AND METHODS We reviewed data from 3,240 consecutive patients who underwent nephrectomy between 2010-2018. Anesthetic parameters evaluated included duration of hypotension, tachycardia, hypothermia, volatile anesthetic use and mean arterial pressure at the post-anesthesia care unit. Outcomes include...
#1Alaina Garbens(UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Margaret S. Pearle(UTSW: University of Texas Southwestern Medical Center)H-Index: 67
Despite high level evidence supporting the use of pharmacotherapy therapy for the prevention of kidney stones, adherence to medications is often poor because of side effects, inconvenience and cost. Furthermore, with a desire for more "natural" products, patients seek dietary and herbal remedies over pharmacotherapy. However, patients are often unaware of the potential side effects, lack of evidence and cost of these remedies. Therefore, in this review we examine the evidence for a few of the co...
OBJECTIVES To investigate the genetic alterations of prostate cancer (PCa) patients with and without intraductal carcinoma of the prostate (IDC-P). MATERIALS AND METHODS We performed targeted sequencing of plasma cell-free DNA on 161 patients of prostate adenocarcinoma (PAC) with IDC-P and 84 cases without IDC-P. Genomic alterations were compared between these two groups. The association between genetic alterations and patients' survival outcomes was also explored. RESULTS Totally, we identified...
Last. Benjamin W Lamb(ARU: Anglia Ruskin University)H-Index: 1
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Two decades since their inception, multidisciplinary teams (MDTs) are widely regarded as the gold standard of cancer care delivery. Benefits of MDT working include improved patient outcomes, adherence to guidelines, and even economic benefits. Benefits to MDT members have also been demonstrated. And increasing body of evidence supports do use of MDTs and provides guidance on best practise. The system of MDTs in cancer care has come under increasing pressure of late, due to the increasing inciden...
Last. Thomas Chi(UCSF: University of California, San Francisco)H-Index: 21
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Pain after percutaneous nephrolithotomy (PCNL) is thought to arise from the dilated renal tract rather than from the skin incision, and the response to traditional analgesics is typically limited.[1] To address this problem, the erector spinae plane block (ESPB) has recently been identified as safe and effective method to target kidney pain. While both T8 and T11 have been reported to be effective in relieving renal colic and surgical pain after PCNL, T11 is hypothesized to have greater ureteral...