Molecular and Cellular Endocrinology
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#1Wen Mei (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Biao Zhu (Capital Medical University)
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Abstract null null Growth differentiation factor 11 (GDF11) has been implicated in the regulation of embryonic development and age-related dysfunction, including the regulation of retinal progenitor cells. However, little is known about the functions of GDF11 in diabetic retinopathy. In this study, we demonstrated that GDF11 treatment improved diabetes-induced retinal cell death, capillary degeneration, pericyte loss, inflammation, and blood-retinal barrier breakdown in mice. Treatment of isolat...
#1Jessica Castro de Vasconcelos (State University of Campinas)H-Index: 1
#2Icleia Barreto de Siqueira (State University of Campinas)
Last. Denise Engelbrecht Zantut-Wittmann (State University of Campinas)H-Index: 17
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Cell destruction in Hashimoto's thyroiditis (HT) involves autoantibodies and cytotoxic T lymphocytes. Thyrocytes maintenance occurs by pro-apoptotic, anti-apoptotic and cell proliferation balance. OBJECTIVES To characterize factors related to the mechanisms of apoptosis and cell proliferation in thyroid cells and intrathyroid lymphocytic infiltrate in HT. METHODS We assessed lymphocytic infiltrate and thyroid cells from HT and normal thyroid by immunohistochemical analysis of cell proliferation ...
#1Thais R. Villela (UFMG: Universidade Federal de Minas Gerais)H-Index: 1
#2Cristina Botelho Barra (UFMG: Universidade Federal de Minas Gerais)H-Index: 5
Last. Ivani Novato Silva (UFMG: Universidade Federal de Minas Gerais)H-Index: 11
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Abstract null null Background null Lifelong glucocorticoid (GC) replacement is the mainstay treatment of congenital adrenal hyperplasia (CAH) due to classic 21-hydroxylase deficiency (21-OHD). Challenges posed by therapeutic management of these patients are well known, but novel insights into the variability in clinical response to GC highlight a role for single nucleotide polymorphisms (SNPs) of the glucocorticoid receptor gene (NR3C1). null null null Aim null To assess whether six commonly stu...
#1Simin Younesi (RMIT: RMIT University)H-Index: 2
#2Sarah J. Spencer (RMIT: RMIT University)H-Index: 33
Last. Luba Sominsky (RMIT: RMIT University)H-Index: 19
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Abstract null null Our recent findings indicate that an acute depletion of monocytes has no sustained effects on ovarian follicle health. Here, we utilised a Cx3cr1-Dtr transgenic Wistar rat model to transiently deplete monocytes and investigated the impact of an acute immune challenge by lipopolysaccharide (LPS) on ovarian follicle health and ovulatory capacity relative to wt once the monocytes had repopulated. Monocyte depletion and repopulation exacerbated the effects of LPS in several domain...
#1Allan W. Chen (UWO: University of Western Ontario)H-Index: 2
#2Kyle K. Biggar (Carleton University)H-Index: 25
Last. Madhulika B. Gupta (UWO: University of Western Ontario)H-Index: 14
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Abstract null null Fetal growth restriction (FGR) is associated with decreased nutrient availability and reduced insulin-line growth factor (IGF)-I bioavailability via increased IGF binding protein (IGFBP)-1 phosphorylation. While protein kinase C (PKC) is implicated in IGFBP-1 hyperphosphorylation in nutrient deprivation, the mechanisms remain unclear. We hypothesised that the interaction of PKCα with protein kinase CK2β and activation of PKCα under leucine deprivation (L0) mediate fetal hepati...
#1Xiangting Chen (SCUT: South China University of Technology)
#2Jie Xie (Peking Union Medical College)H-Index: 1
Last. Lu Chen (JNU: Jinan University)
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Abstract null null Purpose null We previously found the mutation frequency of cytoskeleton-associated protein 2 (CKAP2) was significantly increased in proliferative diabetic retinopathy (PDR) patients through whole exome sequencing. The present study was conducted to explore the expression and possible mechanism of CKAP2 in PDR patients and human retinal capillary endothelial cells (HRCECs) under high-glucose (HG) conditions. null null null Methods null Expression of CKAP2 and p53 in the vitreou...
#1Ana Cl. Camargo (UNESP: Sao Paulo State University)
#2Beatriz Remoli (UNESP: Sao Paulo State University)
Last. Luis A. Justulin (UNESP: Sao Paulo State University)H-Index: 15
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Abstract null null Reproductive cancers in both genders represent serious health problems, whose incidence has significantly risen over the past decades. Although considerable differences among reproductive cancers exist, we aimed to identify similar signaling pathways and key molecular oncomarkers shared among six human reproductive cancers that can advance the current knowledge of cancer biology to propose new strategies for more effective therapies. Using a computational analysis approach, he...
#1Antoine-Guy Lopez (French Institute of Health and Medical Research)H-Index: 3
#2Céline Duparc (French Institute of Health and Medical Research)H-Index: 14
Last. Estelle Louiset (French Institute of Health and Medical Research)H-Index: 23
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The human adrenal cortex is a complex organ which is composed of various cell types including not only steroidogenic cells but also mesenchymal cells, immunocompetent cells and neurons. Intermingling of these diverse cell populations favors cell-to-cell communication processes involving local release of numerous bioactive signals such as biogenic amines, cytokines and neuropeptides. The resulting paracrine interactions play an important role in the regulation of adrenocortical cell functions bot...
#1Shimin Zhuang (SYSU: Sun Yat-sen University)H-Index: 1
#2Jing Xie (NCU: Nanchang University)
Last. Debin Xu (NCU: Nanchang University)
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Ataxin-3 (ATXN3) is a ubiquitous deubiquitinating enzyme that plays an essential role in the carcinogenesis of numerous tumors and stabilizes the expression of substrates by deubiquitination. However, the functional role of ATXN3 in anaplastic thyroid carcinoma (ATC) remains unknown. In this research, we report that ATXN3 was overexpressed in ATC compared to that in paracancerous samples. Moreover, various gain/loss functional assays were performed to indicate that ATXN3 overexpression enhanced ...
#1Erica Louden (Georgia Regents University)H-Index: 1
#2Alexandra Poch (Georgia Regents University)
Last. Lawrence C. Layman (Georgia Regents University)H-Index: 32
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Hypogonadotropic hypogonadism, which may be normosmic (nHH) or anosmic/hyposmic, known as Kallmann syndrome (KS), is due to gonadotropin-releasing hormone deficiency, which results in absent puberty and infertility. Investigation of the genetic basis of nHH/KS over the past 35 years has yielded a substantial increase in our understanding, as variants in 44 genes in OMIM account for ∼50% of cases. The first genes for KS (ANOS1) and nHH (GNRHR) were followed by the discovery that FGFR1 variants ma...
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Molecular biology
Cell biology