Pathologica
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#1Carlo PatriarcaH-Index: 14
#2Carlo Alfredo Clerici (University of Milan)H-Index: 24
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Ugo Cerletti was the inventor of the electroconvulsive therapy (ECT) adopted in 1938 to treat schizophrenia. He had a robust education in anatomical pathology, which also left its mark on the journal Pathologica. Although his name is associated with several important moments and breakthroughs in the history of medicine, Ugo Cerletti’s reputation has partly suffered from the same fate as his treatment. The electroshock was initially widely adopted, partly because of its low cost and relatively ea...
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#1Marco UngariH-Index: 15
Last. Giuseppina FerreroH-Index: 5
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Multiple myeloma accounts for 10-15% of all hematologic malignancies, and 20% of deaths related to cancers of the blood and bone marrow. Diagnosis is defined by the presence of a serum monoclonal spike (M-spike) of more than 3 g/dL or more than 10% clonal plasma cells in the bone marrow and at least one myeloma-defining event, such as hypercalcemia, anemia, bone lesions, or renal impairment. The kidney is a major target organ, and renal impairment is frequently the first manifestation of the dis...
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#3Steven J. Melnick (FIU Herbert Wertheim College of Medicine)H-Index: 20
Background. Adenomyomatous hyperplasia (AMH) of the gallbladder, reported in 1-8.7% of cholecystectomies, consists of cystically dilated sinuses/glands with a surrounding spindle cell proliferation which is thought to be composed of smooth muscle cells. Myofibroblasts are contractile cells that secrete a variety of biochemical modulators causing a “field-effect”. Myofibroblasts can be immunohistochemically distinguished from smooth muscle cells by their desmin negativity. Methods. Eighteen cases...
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#1Linda Daffini (University of Brescia)H-Index: 6
#2Francesca Pagani (University of Brescia)H-Index: 4
Last. Pietro Luigi Poliani (University of Brescia)H-Index: 42
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We report a challenging autopsy case with an insidious clinical presentation with diffuse lepto- and pachymeningeal enhancement in a context of a complex clinical history. Clinical features, neuroradiological and anamnestic data were consistent with central nervous system (CNS) dissemination of a previously known lambda restricted multiple myeloma. Autoptic findings allowed to discard this hypothesis. Unexpectedly, CNS sampling revealed an atypical glial cell proliferation within the sacral meni...
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#1Evelin TorresaniH-Index: 1
#2Ilaria GirolamiH-Index: 8
Last. Claudio GhimentonH-Index: 20
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Congenital granular cell epulis is a rare benign lesion usually arising as single mass from the alveolar ridge of maxillary bone of female newborns, composed of polygonal granular cells that typically stain negative for S-100, in contrast to the adult counterpart. Larger lesions can disturb breathing and breast-feeding, requiring surgery. Prenatal diagnosis is achieved in few cases, even if this would be important for best management of delivery and therapy. Here we present a case of multiple CG...
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#1Antonio Marchetti (University of Chieti-Pescara)H-Index: 23
#2Mattia BarbareschiH-Index: 60
Last. Giancarlo PruneriH-Index: 76
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Next Generation Sequencing (NGS) is increasingly used in diagnostic centers for the assessment of genomic alterations to select patients for precision oncology. The Italian Society of Anatomic Pathology and Diagnostic Cytopathology (SIAPEC) through the Molecular Pathology and Predictive Medicine Study Group (PMMP) has been following the progressive development of centers that have adopted NGS technology in diagnostics over time. In July 2017, a study network on massive parallel sequencing was ac...
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#1Claudia Covelli (Casa Sollievo della Sofferenza)H-Index: 3
#2Diana SacchiH-Index: 7
Last. Maria GuidoH-Index: 44
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#2Diana SacchiH-Index: 7
Last. Maria GuidoH-Index: 44
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#1Marta SbaragliaH-Index: 14
#2Gianluca Businello (UNIPD: University of Padua)H-Index: 3
Last. Angelo Paolo Dei TosH-Index: 60
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#1Ivana CataldoH-Index: 17
Last. Maria GuidoH-Index: 44
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