Tissue Engineering Part C-methods
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#1Xincheng Du (China University of Geosciences (Wuhan))
#2Fang Xu (WHU: Wuhan University)
Last. Gaozhi Ou (China University of Geosciences (Wuhan))
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Background: Skeletal muscle tissue engineering (SMTE) is of great significance in the study of skeletal muscle physiology and pathology, which could be used in skeletal muscle graft. The scientomet...
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#1Guocheng Ding (PKU: Peking University)
#2Guanying Gao (PKU: Peking University)
Last. Yingfang Ao (PKU: Peking University)H-Index: 30
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Meniscus injury is a health problem that greatly affects people's quality of life. In recent years, the number of diagnosed meniscus injury is increasing year by year. If not treated in time and co...
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#1Jeong-Kui Ku (Yonsei University)
#2Yeong Kon JeongH-Index: 1
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Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its osteoinductivity and osteoconductivity. There...
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Since 30 years, bioengineering allowed to reconstruct human tissues using normal human cells. Skin has been one of the first organ to be reconstructed thanks to the development of specific cell culture media and supports favoring the culture of human skin cells such as fibroblasts, keratinocytes or melanocytes. Skin models have evolved from epidermis to complex models including a dermis. The purpose of the present study was to design a reconstructed full thickness skin suitable to perform effica...
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#1Johanna F.A. HuschH-Index: 1
#2Talita Stessuk (Radboud University Nijmegen)
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Osteoclasts are multinucleated cells derived from the hematopoietic monocyte/macrophage lineage that possess the unique capacity to resorb bone. Due to the crucial role of osteoclasts in maintaining bone homeostasis and pathologies, this cell type is pivotal in multiple research areas dedicated to bone physiology in health and disease. Although numerous methods for generation of human osteoclasts are already available, those rely either on cell labeling-based purification or an intermediate adhe...
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#1Bethany Ollington (University of Sheffield)
#2Helen E. Colley (University of Sheffield)H-Index: 15
Last. Craig Murdoch (University of Sheffield)H-Index: 42
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Macrophages play a key role in orchestrating the host immune response towards invading organisms or non-self molecules in the oral mucosa. Three-dimensional (3D) oral mucosal equivalents (OME) containing oral fibroblasts and keratinocytes are used extensively to mimic the human oral mucosa where they have been employed to examine innate immune responses to both bacterial and fungal pathogens as well as to biomaterials. Although the presence of immune cells is critical in generating an immune res...
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#1Zhuoming Liu (FDA: Food and Drug Administration)H-Index: 10
#2Rudell Screven (FDA: Food and Drug Administration)H-Index: 5
Last. Laxminarayana R. Devireddy (FDA: Food and Drug Administration)H-Index: 11
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Mesenchymal stromal cells (MSCs) are potential treatments for a variety of veterinary medical conditions. However, clinical trials have often fallen short of expectations, due in part to heterogeneity and lack of characterization of the MSCs. Identification and characterization of subpopulations within MSC cultures may improve those outcomes. Therefore, the functional heterogeneity of different sized subpopulations of MSCs was evaluated. A high-throughput, biophysical, label-free microfluidic so...
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#1Patrícia ZoioH-Index: 2
#1Patrícia Zoio (NOVA: Universidade Nova de Lisboa)H-Index: 1
Last. Abel Oliva (NOVA: Universidade Nova de Lisboa)H-Index: 19
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Reconstructed human skin models are a valuable tool for drug discovery, disease modeling, and basic research. In the past decades, major progress has been made in this field leading to the development of full-thickness skin models (FTSms) better representative of the native human skin by including the cellular cross talk between the dermal and epidermal layers. However, current available FTSms still present important limitations since they are only suitable for short-term studies, include nonhum...
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#1Maxim N. Karagyaur (MSU: Moscow State University)H-Index: 6
#2Alexandra Rostovceva (MSU: Moscow State University)
Last. Dmitry Stambolsky (MSU: Moscow State University)H-Index: 9
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BACKGROUND Gene therapy is one of the promising approaches for regenerative medicine. Local and long-term expression of essential growth factors allows to achieve the desired therapeutic effect. However, some aspects of prolonged usage of genetic constructs encoding growth factors, such as toxicity, mutagenicity, genotoxicity and ability to disseminate from the injection site and mediate ectopic expression of therapeutic proteins, are poorly investigated. These aspects of gene therapy drugs usag...
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#1Hidenori Kuno (Osaka University)H-Index: 3
#2Takami Akagi (Osaka University)H-Index: 33
Last. Yasushi Shintani (Osaka University)H-Index: 28
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Idiopathic pulmonary fibrosis (IPF) is a severe health problem characterized by progressive fibroblast proliferation and aberrant vascular remodeling. However, the lack of a suitable in-vitro model that replicates cell-specific changes in IPF tissue is a crucial issue. Three-dimensional (3D) cell cultures allow the mimicking of cell specific functions, facilitating development of novel anti-fibrosis drugs. We have established a layer-by-layer (LbL) cell coating technique that enables the constru...
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Top fields of study
Anatomy
Biomedical engineering
Molecular biology
Chemistry
Mesenchymal stem cell
Tissue engineering
Biology
Cell biology