Nephrology Dialysis Transplantation
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#1Alex Pai (UCI: University of California, Irvine)H-Index: 1
#2John Sy (Veterans Health Administration)H-Index: 3
Last. Elani Streja (Veterans Health Administration)H-Index: 48
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Background null Serum globulin is a major component of total protein and can be elevated in inflammatory disease states. While inflammation is common in hemodialysis patients and associated with mortality and morbidity, the association between serum globulin and mortality have never been examined in hemodialysis patients. null Methods null In a retrospective cohort of 104,164 incident hemodialysis patients treated by a large dialysis organization from 2007 to 2011, we explored the association be...
#1Jia-Jin Chen (Memorial Hospital of South Bend)H-Index: 3
#2Tao Han Lee (Memorial Hospital of South Bend)H-Index: 1
Last. Chih-Hsiang Chang (Memorial Hospital of South Bend)H-Index: 20
view all 8 authors...
Background null Restless legs syndrome (RLS) is common among patients with end stage kidney disease (ESKD) and is associated with poor outcomes. Several recently published studies had focused on pharmacological and nonpharmacological treatments of RLS, but an updated meta-analysis has not been conducted. null Methods null The study population was adult ESKD patients on dialysis with RLS. Randomized controlled trials were selected. The primary outcome was reduction in RLS severity. The secondary ...
#1Jana NanoH-Index: 17
#2Ben Schöttker (Heidelberg University)H-Index: 64
Last. Dietrich Rothenbacher (University of Ulm)H-Index: 90
view all 16 authors...
BACKGROUND Inflammatory processes have been implicated in the development of chronic kidney disease (CKD). We investigated the association of a large panel of inflammatory biomarkers reflecting aspects of immunity with kidney function and CKD incidence. METHODS We used data from two independent population-based studies, KORA F4 (discovery, n = 1,110, mean age 70.3 years, 48.7% male) and ESTHER (replication, n = 1,672, mean age 61.9 years, 43.6% male). Serum levels of biomarkers were measured usi...
BACKGROUND The access of obese patients to kidney transplantation is limited despite several studies showing that obese transplant recipients had a better survival rate than those undergoing dialysis. The aim of this study was to compare patient and graft survival rates and post-renal transplant complications in obese patients and non-obese patients and to assess the effect of pre-transplant weight loss in obese patients on transplant outcomes. METHODS We carried out a prospective cohort study u...
#1Yoshihiko Nishiguchi (Kumamoto University)H-Index: 1
#2Yusuke Hata (Kumamoto University)H-Index: 1
Last. Haruko Watanabe-TakanoH-Index: 13
view all 17 authors...
Background null Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathophysiological role in the kidney remains unclear. null Methods null The role of endogenous OSTN was investigated using systemic Ostn-knockout mice (KO). As a model for OSTN administration, liver-specific Ostn-overexpressing mice crossed with KO (KO-Tg) were...
#1Catherine R. Butler (UW: University of Washington)H-Index: 3
#2Kirsten L. Johansen (UMN: University of Minnesota)H-Index: 72
#1Andrea Domingo-Gallego (Autonomous University of Barcelona)H-Index: 2
#2Marc Pybus (Autonomous University of Barcelona)H-Index: 2
Last. Laia Ejarque-Vila (Autonomous University of Barcelona)
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Background null Proteinuria is a well-known risk factor for progressive kidney impairment. Recently, C-terminal cubilin (CUBN) variants have been associated with isolated proteinuria without progression of kidney disease. null Methods null Genetic testing of 347 families with proteinuria of suspected monogenic cause was performed by next-generation sequencing of a custom-designed kidney disease gene panel. Families with CUBN biallelic proteinuria-causing variants were studied at the clinical, ge...
#1Yinghua Chen (NU: Nanjing University)H-Index: 4
#2Kang LiH-Index: 3
Last. Weixin Hu (Southern Medical University)H-Index: 17
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Background null To investigate pregnancy outcomes and risk factors in patients with lupus nephritis (LN). null Methods null A total of 158 pregnancies in 155 women with LN were divided into a remission group and a control group according to whether they achieved complete renal remission (CRR) prior to pregnancy. The adverse pregnancy outcomes and risk factors were retrospectively analyzed. null Results null In the remission group, 130 LN patients with 133 pregnancies (two twin pregnancies) deliv...
#1Gordon Chun-Kau Chan (CUHK: The Chinese University of Hong Kong)H-Index: 2
#2Win Hlaing Than (CUHK: The Chinese University of Hong Kong)
Last. Chi-Bon Leung (CUHK: The Chinese University of Hong Kong)H-Index: 42
view all 12 authors...
Background null There were limited data on the association of adipose microRNA expression with body composition and adverse clinical outcomes in patients with advanced chronic kidney disease (CKD). We aimed to evaluate the association of adipose miR-130b and miR-17-5p expressions with body composition, functional state, cardiovascular outcome and mortality in incident dialysis patients. null Methods null We performed a single-centre prospective cohort study. Patients who were planned for periton...
#1Marina Noris (Mario Negri Institute for Pharmacological Research)H-Index: 77
#2Erica Daina (Mario Negri Institute for Pharmacological Research)H-Index: 19
Last. Giuseppe Remuzzi (Mario Negri Institute for Pharmacological Research)H-Index: 189
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Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury that may be primary or secondary to infections, autoimmune diseases and haematological disorders. Primary C3G and IC-MPGN are rare and the prognosis is unfavourable. Based on immunofluorescence findings, MPGN has been classified into complement-mediated C3 glomerulopathy (C3G), and immune complex-mediated MPGN (IC-MPGN). However, this classification leaves a number of issues unresolved. The finding of genetic and a...
Top fields of study
Intensive care medicine
Kidney disease
Diabetes mellitus