Nephrology Dialysis Transplantation
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#1Laurence Dubourg (University of Lyon System)H-Index: 11
#2Manon Aurelle (University of Lyon System)H-Index: 1
Last. Justine BacchettaH-Index: 24
view all 6 authors...
Background null The assessment of phosphate homeostasis in clinical practice relies on circulating phosphate levels but also on phosphate tubular reabsorption, ideally assessed using the Tubular maximum Phosphate Reabsorption per Glomerular Filtration Rate (TmP/GFR). TmP/GFR reference values were established before the onset of IDMS-standardized creatinine assays, and thus need to be updated. Our objective is to provide reference values for TmP/GFR from childhood to adulthood, using the gold-sta...
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#1Ajinath Kale (Birla Institute of Technology and Science, Pilani)H-Index: 3
#2Himanshu Sankrityayan (Birla Institute of Technology and Science, Pilani)H-Index: 5
Last. Anil Bhanudas Gaikwad (Birla Institute of Technology and Science, Pilani)H-Index: 22
view all 4 authors...
Klotho is a transmembrane anti-ageing protein that exists in three forms, i.e., α-Klotho, β-Klotho, and γ-Klotho with distinct organ-specific expression and functions in the body. Here we focus on α-Klotho (mentioned as 'Klotho' only), abundantly expressed by the distal and proximal convoluted tubules of the kidney. Significant decline in systemic and renal Klotho level is a new hallmark for kidney disease progression. Emerging research portrays Klotho as a promising diagnostic as well as a ther...
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#1Rajiv Agarwal (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 68
#2Stefan D. Anker (Charité - University Medicine Berlin)H-Index: 83
Last. George L. Bakris (UC: University of Chicago)H-Index: 105
view all 17 authors...
BACKGROUND The nonsteroidal mineralocorticoid receptor antagonist finerenone and the sodium-glucose co-transporter-2 inhibitor canagliflozin reduce cardiorenal risk in albuminuric patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). At first glance, the results of FIDELIO-DKD (ClinicalTrials.gov, NCT02540993) and CREDENCE appear disparate. In FIDELIO-DKD, the primary end-point had a 18% (95% CI 7% to 27%) relative risk reduction; in CREDENCE the primary end-point had a 30% (95% ...
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#1David C. Wheeler (UCL: University College London)H-Index: 67
#2Niels Jongs (UMCG: University Medical Center Groningen)H-Index: 5
Last. InvestigatorsH-Index: 4
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Background null Despite renin-angiotensin-aldosterone-system blockade and immunosuppressive treatment, focal segmental glomerulosclerosis (FSGS) often progresses to kidney failure. The objective of this pre-specified analysis of DAPA-CKD was to assess efficacy and safety of dapagliflozin in a small subgroup participants with FSGS confirmed by kidney biopsy. null Methods null In DAPA-CKD, patients with estimated glomerular filtration rate (eGFR) 25-75 mL/min/1.73m2 and urinary albumin-to-creatini...
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#1Nadia M. Chu (Johns Hopkins Medicine)H-Index: 11
#2Jingyao Hong (Johns Hopkins Medicine)
Last. Mara A. McAdams-DeMarco (Johns Hopkins Medicine)H-Index: 29
view all 9 authors...
BACKGROUND Cognitive impairment is common among persons with chronic kidney disease (CKD) due in part to reduced kidney function. Given that physical activity (PA) is known to mitigate cognitive decline, we examined whether associations between CKD stage and global/domain-specific cognitive function differs by PA. METHODS We leveraged 3,223 participants (aged≥60years) enrolled in National Health and Nutrition Examination Survey (NHANES,2011-2014), with at least one measure of objective cognitive...
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#1Yishan Dong (Rochester General Health System)
#2Stephen M. Silver (Rochester General Health System)H-Index: 15
Last. Richard H. Sterns (UR: University of Rochester)H-Index: 33
view all 3 authors...
Spot determinations of the urine creatinine concentration are widely used as a substitute for 24-hour urine collections. Expressed as the amount excreted per gram of creatinine, urine concentrations in a single-voided sample are often used to estimate 24-hour excretion rates of protein, sodium, potassium, calcium, magnesium, urea, and uric acid. These estimates are predicated on the assumption that daily creatinine excretion equals 1 gm (and that a urine creatinine concentration of 100 mg/dl ref...
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#1Nessn H. Azawi (UCPH: University of Copenhagen)H-Index: 8
#2Mia Jensen (SDU: University of Southern Denmark)H-Index: 1
Last. Lars H. Lund (OUH: Odense University Hospital)H-Index: 41
view all 6 authors...
Background null Following nephrectomy, the remaining kidney tissue adapts by an increase in GFR. In rats, hyperfiltration can be transferred by plasma. We examined whether natriuretic peptides (ANP, BNP) increase in plasma proportionally with kidney mass reduction and, if so, whether the increase relates to an increase in GFR. null Methods null Patients (n = 54) undergoing partial or total unilateral nephrectomy at two Danish centers were followed for one year in an observational study. Glomerul...
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#1Davide ViggianoH-Index: 27
#2Annette Bruchfeld (Karolinska University Hospital)H-Index: 29
Last. Giovambattista CapassoH-Index: 33
view all 25 authors...
Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment,...
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#1Chang Chu (Heidelberg University)H-Index: 6
#2Xin Chen (Heidelberg University)H-Index: 2
Last. Berthold HocherH-Index: 44
view all 7 authors...
Background null Angiopoietin-2 (Ang-2) plays a pivotal role in pathological vascular remodeling and angiogenesis. Both vascular mechanisms are active in patients with end-stage renal disease (ESRD) and may contribute to the high mortality in these patients. The aim of this multicenter prospective cohort study was to investigate baseline serum Ang-2 concentrations in ESRD patients on hemodialysis (HD) for their ability to predict all-cause mortality. null Methods null We conducted a prospective c...
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#1Rebecca Noble (Royal Derby Hospital)H-Index: 2
#2Nicholas M. Selby (Royal Derby Hospital)H-Index: 29
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