#2Divakar Raj(IITs: Indian Institutes of Technology)
Last. Mukesh Doble(IITs: Indian Institutes of Technology)H-Index: 56
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Abstract null null Anticancer effect of resveratrol and the role of sodium/lithium/calcium exchanger in context with calcium ions are studied in human cervical cancer cell line. This therapeutic approach using siNCLX mediated gene silencing and drug therapy with resveratrol indicates the disruption of calcium homeostasis, increase in caspase (-3, 8, 9) mRNA expressions and DNA damage leading to apoptotic cell death. Monitoring the intracellular Ca2+ changes using fluo-4AM indicates highest rise ...
#1Chien-Jung Lin(WashU: Washington University in St. Louis)H-Index: 1
#2Robert P. Mecham(WashU: Washington University in St. Louis)H-Index: 91
Abstract null null Smooth muscle cells (SMCs) are specialized cells present in many organs where they serve diverse tissue-specific functions. Using the Tabula Muris compendium of single-cell RNA sequencing data, we extracted individual SMC transcriptomes from eight mouse tissues to investigate the transcriptomic landscape of tissue-specific SMCs. We identified marker genes, signaling pathways, and biological processes enriched in tissue-specific SMCs, and inferred potential ligand-receptor inte...
Last. Maria-Jesus Sanz(ISCIII: Carlos III Health Institute)H-Index: 1
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Abstrat null null Primary hypercholesterolemia, a metabolic disorder characterized by elevated circulating levels of cholesterol products, mainly low-density lipoproteins, is associated with arteriosclerosis development. Cardiovascular disease, predominantly myocardial infarction and stroke, remains the main cause of death worldwide, with atherosclerosis considered to be the most common underlying pathology. In addition to elevated plasma levels of low-density lipoproteins, low-grade systemic in...
Last. Guoqing Yang(HUST: Huazhong University of Science and Technology)
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Abstract null null Bladder cancer is the most common cancer in the urinary system which has threatened lives. Increasing evidence has shown that lncRNAs were expressed in cancer cells as a biomarker and might regulate cancer cell development and progression. It was reported that ADAMTS9-AS1 plays a suppressive role in tumor cell growth and proliferation in prostate cancer. However, it remains unclear whether ADAMTS9-AS1 influences the function of bladder cancer cells. In this study, we detected ...
#1Qianxing Zou(Guangzhou Institutes of Biomedicine and Health)
#2Huayu Qi(Guangzhou Institutes of Biomedicine and Health)
Accumulating evidences suggest that the composition and functional roles of ribosomes are heterogeneous in cells, partly due to the temporal-spatial expression of paralogous ribosomal proteins (RPs), of which functional relationships remain largely unexplored. In mouse, the X chromosome-linked RPL39 and its male germline specific paralog RPL39 L are thought to express mutually exclusively due to the meiotic sex chromosome inactivation, hinders the understanding of their functional relationships....
Last. Weihong Zhong(Zhejiang University of Technology)H-Index: 10
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Abstract null null Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome, ranging from benign steatosis to severe non-alcoholic steatohepatitis. Recently, it has been found that lipophagy plays a pivotal role in lipid turnover, which can alleviate NAFLD in hepatocytes. In this study, we found that a highly sulfated glucuronomannan hexamer G6S1 has the ability to enhance lipophagy. When treated with G6S1, the number and the size of lipid droplet...
#1Lohit Khera(Weizmann Institute of Science)H-Index: 1
#2Sima Lev(Weizmann Institute of Science)H-Index: 39
The tyrosine kinase receptor AXL of the TAM (TYRO3, AXL and MERTK) family is considered as a promising therapeutic target for different hematological cancers and solid tumors. AXL is involved in multiple pro-tumorigenic processes including cell migration, invasion, epithelial-mesenchymal transition (EMT), and stemness, and recent studies demonstrated its impact on cancer metastasis and drug resistance. Extensive studies on AXL have highlighted its unique characteristics and physiological functi...
Last. Paola Falletta(UniSR: Vita-Salute San Raffaele University)
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Abstract null null In recent years considerable progress has been made in identifying the impact of mRNA translation in tumour progression. Cancer cells hijack the pre-existing translation machinery to thrive under the adverse conditions originating from intrinsic oncogenic programs, that increase their energetic demand, and from the hostile microenvironment. A key translation program frequently dysregulated in cancer is the Integrated Stress Response, that reprograms translation by attenuating ...
#1Debdatta Halder(IACS: Indian Association for the Cultivation of Science)H-Index: 2
#2Ditipriya Mallick(IACS: Indian Association for the Cultivation of Science)H-Index: 1
Last. Siddhartha S. Jana(IACS: Indian Association for the Cultivation of Science)H-Index: 17
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Cell migration is a key step of cancer metastasis, immune-cell navigation, homing of stem cells and development. What adds complexity to it is the heterogeneity of the tissue environment that gives rise to a vast diversity of migratory mechanisms utilized by cells. A majority of cell motility mechanisms reported elsewhere largely converge in depicting the importance of the activity and complexity of actomyosin networks in the cell. In this review, we highlight the less discussed functional diver...
Abstract null null Background null Glioma is the most prevalent brain tumor with high mortality and morbidity and the prognosis of patients remain very poor. Glioma therapy is largely limited by the extraordinary invasive capability in glioma and the clinical prognostic biomarker of LGG and GBM remain lacking. So it is urgent and important for us to identify a valuable biomarker to treat glioma patients. SCAMP4 (Secretory Carrier-Associated Membrane Protein 4) has not been reported to be linked ...