American Journal of Medical Genetics
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#1Bronwyn Overs (Neuroscience Research Australia)H-Index: 11
#2Gloria Roberts (UNSW: UNSW Sydney)H-Index: 26
Last. Janice M. Fullerton (UNSW: UNSW Sydney)H-Index: 35
view all 11 authors...
Bipolar disorder (BD) is associated with a 20-30-fold increased suicide risk compared to the general population. First-degree relatives of BD patients show inflated rates of psychopathology including suicidal behaviors. As reliable biomarkers of suicide attempts (SA) are lacking, we examined associations between suicide-related polygenic risk scores (PRSs)-a quantitative index of genomic risk-and variability in brain structures implicated in SA. Participants (n = 206; aged 12-30 years) were unre...
#1Manuela Kouakou (Cardiff University)H-Index: 1
#2D. F. Cameron (Cardiff University)H-Index: 17
Last. Nicholas John Bray (Cardiff University)H-Index: 28
view all 7 authors...
Common genetic variation appears to largely influence risk for neuropsychiatric disorders through effects on gene regulation. It is therefore possible to shed light on the biology of these conditions by testing for enrichment of associated genetic variation within regulatory genomic regions operating in specific tissues or cell types. Here, we have used the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq) to map open chromatin (an index of active regulatory g...
#1Xiaotong Wang (UQ: University of Queensland)
#2Tian Lin (UQ: University of Queensland)H-Index: 12
Last. Douglas F. Levinson (SU: Stanford University)H-Index: 86
view all 6 authors...
This study investigates if genetic factors could contribute to the high rate of mood disorders reported in a U.S. community known to have a restricted early founder population (confirmed here through runs of homozygosity analysis). Polygenic scores (PGSs) for eight common diseases, disorders, or traits, including psychiatric disorders, were calculated in 274 participants (125 mood disorder cases) who each reported three or four grandparents born in the community. Ancestry-matched controls were s...
#1Sarah M. C. Colbert (UCB: University of Colorado Boulder)H-Index: 4
#2Scott A Funkhouser (UCB: University of Colorado Boulder)H-Index: 1
Last. Luke M. Evans (UCB: University of Colorado Boulder)H-Index: 19
view all 8 authors...
Genetic correlations suggest that the genetic relationship of alcohol use with internalizing psychopathology depends on the measure of alcohol use. Problematic alcohol use (PAU) is positively genetically correlated with internalizing psychopathology, whereas alcohol consumption ranges from not significantly correlated to moderately negatively correlated with internalizing psychopathology. To explore these different genetic relationships of internalizing psychopathology with alcohol use, we perfo...
#1José J. Morosoli (UQ: University of Queensland)H-Index: 4
#2Lucía Colodro-Conde (UQ: University of Queensland)H-Index: 21
Last. Sarah E. Medland (UQ: University of Queensland)H-Index: 102
view all 4 authors...
Our beliefs about the heritability of psychiatric traits may influence how we respond to the use of genetic information in this area. In the present study, we aim to inform future education campaigns as well as genetic counseling interventions by exploring common fears and misunderstandings associated with learning about genetic predispositions for mental health disorders. We surveyed 3,646 genetic research participants from Australia, and 960 members of the public from the United Kingdom, and t...
#1Judith Schmitz (University of St Andrews)H-Index: 12
#2Filippo Abbondanza (University of St Andrews)H-Index: 3
Last. Silvia Paracchini (University of St Andrews)H-Index: 29
view all 3 authors...
Funding information: Deutsche Forschungsgemeinschaft, Grant/Award Number: SCHM 3530/1-1 (418445085); Royal Society, Grant/Award Number: UF150663; UK Medical Research Council and Wellcome, Grant/Award Number: 217065/Z/19/Z; Wellcome Trust, Grant/Award Number: 105621/Z/14/Z
#1Megan Skelton (KCL: King's College London)H-Index: 1
#2Christopher Rayner (KCL: King's College London)H-Index: 12
Last. Thalia C. Eley (KCL: King's College London)H-Index: 74
view all 10 authors...
The requirement for large sample sizes for psychiatric genetic analyses necessitates novel approaches to derive cases. Anxiety and depression show substantial genetic overlap and share pharmacological treatments. Data on prescribed medication could be effective for inferring case status when other indicators of mental health are unavailable. We investigated self-reported current medication use in UK Biobank participants of European ancestry. Medication Status cases reported using antidepressant ...
#1Anna R. Docherty (VCU: Virginia Commonwealth University)H-Index: 23
#2Brent M. KiousH-Index: 8
Last. Hilary Coon (UU: University of Utah)H-Index: 78
view all 10 authors...
Genome-wide association studies (GWAS) provide valuable information in research contexts regarding genomic changes that contribute to risks for complex psychiatric conditions like major depressive disorder. GWAS results can be used to calculate polygenic risk scores (PRS) for psychiatric conditions, such as bipolar disorder or schizophrenia, as well as for other traits, such as obesity or hypertension. Private companies that provide direct-to-consumer (DTC) genetic testing sometimes report PRS f...
#1Yasmin Namavar (Utrecht University)
#2Denise Joanne Duineveld (Utrecht University)
Last. Janneke Zinkstok (Utrecht University)H-Index: 17
view all 7 authors...
Hyperprolinemia Type I and II are genetic metabolic disorders caused by disrupted proline degradation. It has been suggested that hyperprolinemia is associated with increased risk of developmental and mental disorders but detailed information on the psychiatric phenotype in hyperprolinemic patients is limited. Following PRISMA guidelines, we carried out a systematic review to clarify psychiatric phenotypes in patients with hyperprolinemia. We screened 1753 studies and included 35 for analysis, i...
#1Murray B. Stein (VHA: Veterans Health Administration)H-Index: 148
#2Sonia Jain (UCLA: University of California, Los Angeles)H-Index: 3
Last. Ronald C. Kessler (Harvard University)H-Index: 314
view all 11 authors...
Suicide is a major public health problem. The contribution of common genetic variants for major depressive disorder (MDD) independent of personal and parental history of MDD has not been established. Polygenic risk score (using PRS-CS) for MDD was calculated for US Army soldiers of European ancestry. Associations between polygenic risk for MDD and lifetime suicide attempt (SA) were tested in models that also included parental or personal history of MDD. Models were adjusted for age, sex, tranche...
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