BMC Gastroenterology
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#1A Martín-Cardona (University of Barcelona)H-Index: 4
#2Josep Lloreta Trull (Autonomous University of Barcelona)
Last. Anna Pérez-Madrigal (University of Barcelona)
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BACKGROUND SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is poorly known. Transmission electron microscopy (TEM) is a useful tool that provides an understanding of SARS-CoV-2 invasiveness, replication and dissemination in body cells but information outside the respiratory tract is very limited. We report two cases of severe intestinal com...
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#1Masaru KomatsuH-Index: 1
#2Motoharu HiraiH-Index: 1
Last. Shirou KuwabaraH-Index: 10
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BACKGROUND Although rare, several immune-related adverse effects can be life-threatening. Here, we describe a metastatic gastric cancer patient presenting with nivolumab-related myasthenia gravis and myocarditis, a previously unreported adverse effect of gastric cancer treatment. CASE PRESENTATION A 66-year-old man with metastatic gastric cancer visited the emergency department because of dizziness after the first dose of nivolumab. Diagnoses of nivolumab-related myasthenia gravis and myocarditi...
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#1Chang-li LiH-Index: 1
#2Meng Jiang (HUST: Huazhong University of Science and Technology)H-Index: 5
Last. Li-gang Xu (HUST: Huazhong University of Science and Technology)
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BACKGROUND Acute pancreatitis is a common and potentially lethal gastrointestinal disease, but literatures for the disease burden are scarce for many countries. Understanding the current burden of acute pancreatitis and the different trends across various countries is essential for formulating effective preventive intervenes. We aimed to report the incidence, mortality, and disability-adjusted life-years (DALYs) caused by acute pancreatitis in 204 countries and territories between 1990 and 2019....
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BACKGROUND There are few reports about the effect of glucocorticoids in the treatment of acute pancreatitis in humans. This study aims to evaluate the effect of glucocorticoids in the treatment of acute pancreatitis by propensity score matching analysis. RESULTS Acute pancreatitis patients admitted between 2014 and 2019 were collected from the database and analyzed. Included patients were divided into the glucocorticoids-used group (GC group) and the non-glucocorticoids-used group (NGC group) ac...
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#1Fahdah F. Al-sunaid (Princess Nora bint Abdul Rahman University)
#2Maha M. Al-homidi (Princess Nora bint Abdul Rahman University)
Last. Abeer S. Alzaben (Princess Nora bint Abdul Rahman University)H-Index: 5
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BACKGROUND Adherence to a gluten-free diet (GFD) and food insecurity (FI) may influence health-related quality of life (HRQOL) in individuals with celiac disease (CD). This study aimed to investigate the association between adherence to a GFD, FI, and HRQOL in individuals with CD. METHODS This cross-sectional study included 97 adults (mean age: 34 ± 9 years) diagnosed with CD. The participants were on a GFD for more than 6 months. Sociodemographic characteristics and medical history were assesse...
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#1Takayuki Ando (University of Toyama)H-Index: 26
#2Takahiko Nakajima (University of Toyama)H-Index: 11
Last. Shinya Kajiura (University of Toyama)H-Index: 10
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Background null Constitutional mismatch repair deficiency (CMMRD) is an extremely rare autosomal recessive hereditary disease characterized by the absence of mismatch repair gene activity from birth, which results in brain tumors, colonic polyposis, gastrointestinal cancers, and lymphomas later in life. An aggressive approach, including colectomy or proctocolectomy, is recommended for the treatment of colorectal cancer. Additionally, partial colectomy with subsequent endoscopic surveillance may ...
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#1Narinder Grover (PGIMER: Post Graduate Institute of Medical Education and Research)
#2Prateek Bhatia (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 12
Last. Vishal Sharma (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 18
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BACKGROUND Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively. Exact role of these polymorphisms in South Asian population with inflammatory bowel disease (IBD) is uncertain. METHODS We included consecutive patients with IBD who were initiated on thiopurines at a center in North India. The dosage of thiopurines was titrated using reg...
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#1Tomoyuki Nishimura (Hiroshima University)H-Index: 3
#2Shiro Oka (Hiroshima University)H-Index: 52
Last. Hidenori Tanaka (Hiroshima University)H-Index: 4
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BACKGROUND In Japan, endoscopic submucosal dissection (ESD) is standardized for large colorectal tumors. However, its validity in the elderly population is unclear. We aimed to evaluate the safety and efficacy of ESD for colorectal tumors in elderly patients aged over 80 years. METHODS ESD was performed on 178 tumors in 165 consecutive patients aged over 80 years between December 2008 and December 2018. We retrospectively evaluated the clinicopathological characteristics and clinical outcomes of...
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#1Yosuke Toya (Iwate Medical University)H-Index: 11
#2Masaki Endo (Iwate Medical University)H-Index: 15
Last. Tamotsu Sugai (Iwate Medical University)H-Index: 32
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BACKGROUND Clinical outcomes and prognostic factors for survival after endoscopic submucosal dissection (ESD) in older patients aged ≥ 85 years with early gastric cancer (EGC) are not well defined. The aim of this study was to investigate the clinical outcomes and prognostic factors for survival after ESD in older patients aged ≥ 85 years with EGC. METHODS Clinical outcomes of 70 patients aged ≥ 85 years with EGC treated with ESD were evaluated retrospectively. Prognostic factors for overall sur...
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#1Yuki AoyamaH-Index: 1
#2Tomoki InabaH-Index: 18
Last. Satoko NakamuraH-Index: 3
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BACKGROUND Serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. PR3-ANCA is a useful serological marker for disease severity in ulcerative colitis (UC). The purpose of this study was to investigate whether PR3-ANCA levels could also predict the success of induction therapy and to compare its performance against other markers, including serum CRP and fecal hemoglobin. METHODS This was a multicenter retrospe...
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