Clinical & Translational Oncology
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#1Abu Hazafa (H.I., S.I.: University of Agriculture, Faisalabad)H-Index: 6
#2M O Iqbal (Ocean University of China)
Last. Muhammad Naeem (Hebei Normal University)H-Index: 1
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Natural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic a...
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#1M. Murali (Amrita Vishwa Vidyapeetham)
#2Ayana R Kumar (Amrita Vishwa Vidyapeetham)H-Index: 2
Last. Lekshmi R. Nath (Amrita Vishwa Vidyapeetham)H-Index: 6
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An antibody-drug conjugate (ADC) is an advanced chemotherapeutic option with immense promises in treating many tumor. They are designed to selectively attack and kill neoplastic cells with minimal toxicity to normal tissues. ADCs are complex engineered immunoconjugates that comprise a monoclonal antibody for site-directed delivery and cytotoxic payload for targeted destruction of malignant cells. Therefore, it enables the reduction of off-target toxicities and enhances the therapeutic index of t...
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BACKGROUND Hand osteoarthritis (HOA) is one of the most common causes of pain and functional disability in western countries and there is still no definitive cure. Low-dose radiation therapy (LDRT) has anti-inflammatory properties that have shown to be effective in the symptomatic relief of various degenerative musculoskeletal disorders. We designed a clinical protocol using LDRT for symptomatic HOA and present results and tolerance in the first 100 patients included. MATERIALS AND METHODS Betwe...
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#1X Zhao (WMU: Weifang Medical University)
#2A Chen (WMU: Weifang Medical University)
Last. Y Tao (WMU: Weifang Medical University)
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Huntington disease (HD) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (HTT). Huntingtin-associated protein 1 (HAP1) is the first protein identified as an interacting partner of huntingtin, which is directly associated with HD. HAP1 is mainly expressed in the nervous system and is also found in the endocrine system and digestive system, and then involves in the occurrence of the related endocrine diseases, dig...
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#1L. Zhu (ZJNU: Zhejiang Chinese Medical University)
#2L. Zhao (Hong Kong Baptist University)
Last. S. Liu (ZJNU: Zhejiang Chinese Medical University)
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Microribonucleic acids (miRNAs) are small non-coding ribonucleic acids (ncRNAs), which can affect recognition of homologous sequences and interfere with transcription. It plays key roles in the initiation, development, resistance, metastasis or recurrence of cancers. Identifying circulatory indicators will positively improve the prognosis and quality of life of patients with early cancer. Previous studies have shown that miRNA is highly involved in cancer. In addition, miRNA derived from cancers...
1 CitationsSource
#1Jinwei Lei (CQMU: Chongqing Medical University)H-Index: 1
#2Shipeng Guo (CQMU: Chongqing Medical University)H-Index: 5
Last. Shengchun Liu (CQMU: Chongqing Medical University)H-Index: 22
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Lysophosphatidic acid (LPA) is a bioactive molecule which participates in many physical and pathological processes. Although LPA receptor 6 (LPAR6), the last identified LPA receptor, has been reported to have diverse effects in multiple cancers, including breast cancer, its effects and functioning mechanisms are not fully known. Multiple public databases were used to investigate the mRNA expression of LPAR6, its prognostic value, and potential mechanisms in breast cancer. Western blotting was pe...
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Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) and for patients who refuse surgery. The aim of this study was to evaluate the effectiveness and safety of primary SBRT in patients with early-stage NSCLC. Retrospective multicenter study of 397 patients (416 primary lung tumours) treated with SBRT at 18 centres in Spain. 83.2% were men. The median age was 74.4 years. In 94.4% of cases, the t...
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#2Carlos CampsH-Index: 31
Last. Cristina Antón-Rodriguez (Universidad Francisco de Vitoria)H-Index: 1
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PURPOSE To review current measures for renal cancer care and develop a comprehensive and updated list of measures for their practical use in Spain. METHODS The study was developed by Fundacion ECO, a Spanish foundation aiming to improve oncology quality of care. A systematic literature review was carried out to identify measures and knowledge gaps. A scientific committee composed of nine experts reviewed the literature findings and added measures. A preliminary list of 42 measures was evaluated ...
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Background null Gliomas is a major challenge of current medical system, and thousands of people are struggling in the pain of this disease worldwide. In the last decade, the functions of miRNAs have been revealed by many studies, and the intervention on miRNA dysfunctions has been thought as a promising way to counter cancer. MiR-493-5p has been identified as a tumor inhibitor to suppress the progressions of several tumors while its role in gliomas remains unknown. Hence, the study investigated ...
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#1D Geng (Zhengzhou University)
#2Q Guo (Zhengzhou University)
Last. Li Xuyan (Zhengzhou University)H-Index: 6
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Objective null To evaluate the genomic and immune characteristics of non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations from a retrospective dataset with molecular spectrum, tumor mutational burden (TMB), and programmed death-ligand 1 (PD-L1) expression, as well as to evaluate the efficacy of immune checkpoint inhibitors (ICIs). null Methods null A total of 283 patients with EGFR ex20ins mutations who were diagnosed with...
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