Expert Review of Gastroenterology & Hepatology
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Introduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic liver disease and contributes to the development of hepatocarcinogenesis.Areas covered: This review focuses on the impact of oxidative stress in various etiologies of chronic liver disease such as alcoholic liver disease (ALD), nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. The efficacy of antioxidants in laboratory, animal, and clinical studies in c...
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OBJECTIVE Recent years have registered the advent of novel treatment options for metastatic renal cell carcinoma (mRCC), including combination therapies with immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs). Immuno-TKI combinations have been suggested to improve clinical outcomes but may also result in increased toxicity, including gastrointestinal (GI) adverse events. METHODS Herein, we performed a meta-analysis aimed at comparing the risk of certain GI toxicities in mR...
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#1Brian Lee Juin Hsien (NTU: Nanyang Technological University)
#2Vishal G. Shelat (TTSH: Tan Tock Seng Hospital)H-Index: 21
INTRODUCTION Spleen angiosarcoma (SA) is a rare malignant neoplasm that arises from the splenic vascular endothelium, with only around 300 cases reported to date. Due to a limited number of reported cases, there is a paucity of data and a lack of understanding of its presentation, diagnosis, and management. In this study, we aim to provide a comprehensive review of SA. AREAS COVERED On 27 February 2021, a literature search was done Pubmed and Embase database. The search yielded 122 articles invo...
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#1Jiarong Lin (Dalian Medical University)
#2Gongkai Liu (NSU: Nova Southeastern University)
Last. Zhijun Duan (Dalian Medical University)
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Introduction null Esophagus dysmotility is a crucial risk factor of gastroesophageal reflux disease (GERD), which is one of the most common diseases in digestive medicine globally. This review emphasizes the mechanisms of esophagus dysmotility in diabetes and summarizes more targeted treatments for these patients to avoid the overuse of proton pump inhibitors (PPIs). null Areas covered null Diabetes mellitus (DM) is a clear factor that must not be neglected in the development of GERD. Previous s...
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#1Charlotte M. Verburgt (UvA: University of Amsterdam)H-Index: 1
#2W Pepijn Heutink (UU: Utrecht University)
Last. Merit M. Tabbers (Boston Children's Hospital)H-Index: 29
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Introduction: Current therapies in pediatric Inflammatory Bowel Diseases (IBD) target the immune system and often fail to sustain long-term remission. There is a high need for development of alternative treatment strategies such as antibiotics in pediatric IBD.Areas covered: This study systematically assessed efficacy and safety of antibiotics in pediatric IBD. CENTRAL, EMBASE, and Medline were searched for Randomized Controlled Trials (RCTs). Quality assessment was conducted with the Cochrane r...
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#1John M. Azizian (UCLA Medical Center)
#2Camellia Dalai (UCLA Medical Center)H-Index: 1
Last. James H. Tabibian (UCLA: University of California, Los Angeles)H-Index: 14
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Introduction: Medical professional liability (MPL) is a notable concern for many clinicians, especially in procedure-intensive specialties such as gastroenterology (GI). Comprehensive understanding of the basis for MPL claims can improve gastroenterologists' practice, lower MPL risk, and improve the overall patient care experience. This is particularly relevant in the setting of the increasing average compensation per paid GI-related MPL claim, and evolving healthcare delivery patterns and regul...
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#1Marla Dubinsky (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 76
#2Iris Dotan (Rabin Medical Center)H-Index: 51
Last. Laurie Keefer (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 40
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Introduction: Patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, often have comorbid anxiety and depression that affects their quality of life (QoL) and management of their IBD.Areas covered: A systematic literature review (SLR) was conducted to identify articles and conference abstracts on comorbid anxiety and depression in IBD patients using MEDLINE® and Embase® (January 2003 - June 2018). The impact of these psychological comorbidities on QoL and...
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#1Sarah Blacker (Royal Surrey County Hospital)
#2Rajiv P. Lahiri (Royal Surrey County Hospital)H-Index: 1
Last. Adam E Frampton (Royal Surrey County Hospital)H-Index: 33
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Recent studies have indicated that preoperative biliary drainage (PBD) should not be routinely performed in all patients suffering from obstructive jaundice before pancreatic surgery. The severity of jaundice that mandates PBD has yet to be defined. The evaluated paper examines the impact of PBD on intra-operative, and post-operative outcomes in patients initially presenting with severe obstructive jaundice (bilirubin ≥250 μmol/L). In this key paper evaluation, the impact of PBD versus a direct ...
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#1Diego Currò (UCSC: Catholic University of the Sacred Heart)H-Index: 19
Introduction : Patients with irritable bowel syndrome (IBS) frequently resort to natural products, or request doctors to prescribe them, to relieve their symptoms, due to the poor efficacy and tolerability of several traditional drugs. Products containing fibre are among the most used and their clinical efficacy is discussed here based on the most recent scientific evidence. Areas covered : A literature search was carried out to identify the most significant publications in order to deal with th...
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#1Yuki Ong (NUS: National University of Singapore)
#2Vishal G. Shelat (NTU: Nanyang Technological University)H-Index: 1
Last. Vishal G. Shelat (NUS: National University of Singapore)H-Index: 21
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Introduction: Acute pancreatitis (AP) is a common gastrointestinal disease with a wide spectrum of severity and associated morbidity. Developed in 1974, the Ranson score was the first scoring system to prognosticate AP. Over the past decades, while the Ranson score remains widely used, it was also identified to have certain limitations, such as having low predictive power. It has also been criticized for its 48-hour requirement for computation of the final score, which has been argued to potenti...
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Pathology
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