Neurochemical Research
Papers 9,088
1 page of 909 pages (9,088 results)
#1Thuy Trang Nguyen (HCMUT: Ho Chi Minh City University of Technology)H-Index: 10
Last. Giau Van Vo (VNUHCM: Vietnam National University, Ho Chi Minh City)H-Index: 2
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Neurodegenerative disorders are distinguished by the gradual deterioration of the nervous system’s structure and function due to oxidative stress, mitochondrial dysfunction, protein misfolding, excitotoxicity, and neuroinflammation. Among these NDs, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis characterized an increasing dysfunction and loss of neuronal structure leading to neuronal cell death. Although there is currently no drug to totally re...
#1Haiju Zhang (WHU: Wuhan University)
#2S Yu (WHU: Wuhan University)H-Index: 1
Last. Bao-Zhen Yao (WHU: Wuhan University)H-Index: 1
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Epilepsy (SE) is a common and serious neurological disease. NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome participates in the pathogenesis of SE, while its underlying mechanism is still unclear. Here, we attempted to explore the mechanism of action of NLRP3 inflammasome in SE. SE mouse model was constructed by administration of kainic acid (KA). Astrocytes were treated with KA to mimic SE cell model. MCC950 (NLRP3 inhibitor) and Z-YVAD-FMK (Caspase-1 inhibitor) were use...
Chronic visceral pain (CVP) is one of the common symptoms of many diseases triggered by underlying diseases of the internal organs of the human body. Its causes include vascular mechanisms, mechanical factors, persistent inflammation, and unexplained functional mechanisms. Although the pathogenesis is unclear, more and more research has begun to shift from the neuronal aspect to the glial cells in recent years. Some data highlight that the spinal glial cells, particularly the microglia and astro...
#1Changkai Hou (Tianjin Medical University General Hospital)H-Index: 1
#2Quan-lei Liu (Tianjin Medical University General Hospital)H-Index: 1
Last. Xinyu Yang (Tianjin Medical University General Hospital)H-Index: 8
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The glymphatic system (GS) plays an important role in subarachnoid hemorrhage (SAH). Nimodipine treatment provides SAH patients with short-term neurological benefits. However, no trials have been conducted to quantify the relationship between nimodipine and GS. We hypothesized that nimodipine could attenuate early brain injury (EBI) after SAH by affecting the function of the GS. In this study, we assessed the effects of nimodipine, a dihydropyridine calcium channel antagonist, on mice 3 days aft...
#1Chao Liu (DUT: Dalian University of Technology)H-Index: 4
#2Hong Zhao (DUT: Dalian University of Technology)H-Index: 5
Last. Xin-Yu Yu (DUT: Dalian University of Technology)H-Index: 5
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Accumulated evidence demonstrated that an elevated plasma homocysteine level, hyperhomocysteinemia, induced cognitive impairment in animals, elderly and the patients with neurodegenerative diseases. To date, the underlying cellular and molecular mechanisms by which hyperhomocysteinemia induces cognitive impairment has not been clearly defined. The purpose of this study was to investigate the possible cellular and molecular mechanisms behind hyperhomocysteinemia signaling in rat memory impairment...
#1Thalita Mázala-de-Oliveira (UFF: Fluminense Federal University)H-Index: 2
#2Camila Saggioro de Figueiredo (UFF: Fluminense Federal University)H-Index: 4
Last. Elizabeth Giestal-de-Araujo (NIST: National Institute of Standards and Technology)H-Index: 3
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Ouabain is a classic Na+K+ATPase ligand and it has been described to have neuroprotective effects on neurons and glial cells at nanomolar concentrations. In the present work, the neuroprotective and immunomodulatory potential of ouabain was evaluated in neonatal rat retinal cells using an optic nerve axotomy model in vitro. After axotomy, cultured retinal cells were treated with ouabain (3 nM) at different periods. The levels of important inflammatory receptors in the retina such as TNFR1/2, TLR...
#1Shu Pan (WNMC: Wannan Medical College)H-Index: 2
#2Yi-Jin Wu (WNMC: Wannan Medical College)H-Index: 4
Last. Jian Zuo (WNMC: Wannan Medical College)H-Index: 14
view all 7 authors...
Rheumatoid arthritis (RA) is one of the most common autoimmune disease and until now, the etiology and pathogenesis of RA is not fully understood, although dysregulation of immune cells is one of the leading cause of RA-related pathological changes. Based on current understanding, the priority of anti-rheumatic treatments is to restore immune homeostasis. There are several anti-rheumatic drugs with immunomodulatory effects available nowadays, but most of them have obvious safety or efficacy shor...
#1Mengqiao Ren (Shihezi University)H-Index: 2
#2Mengyu Zhang (Shihezi University)H-Index: 1
Last. Yan-li Hu (Shihezi University)H-Index: 6
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Hydroxysafflor yellow A (HSYA) is an extract from Carthamus tinctorius L. dry flowers (Compositae). HSYA has been shown to have neuroprotective effects on several Alzheimer's disease (AD) models. However, the exact mechanisms by which HSYA regulates neuroinflammation have still not been clarified. In this study, we investigated the mechanism by which HSYA regulates microglial activation and neuroinflammation via TREM2, and further clarified its underlying molecular mechanism. We silenced TREM2 i...
#1Xinfan Zhang (Binzhou University)H-Index: 1
#2Shuhua Wu (Binzhou University)H-Index: 3
Last. Jianmin Li (Binzhou University)H-Index: 3
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Epilepsy is one of the most common chronic neurological diseases. There is increasing evidence for ferroptosis playing an important role in the occurrence and development of epilepsy. Vitamin E is a common fat-soluble antioxidant that can regulate ferroptosis. The aim of this study was to investigate the effects of vitamin E on ferroptosis of hippocampal neurons in epileptic rats. Sixty-four male Sprague-Dawley (SD) rats were randomly divided into control, pentylenetetrazol (PTZ; 35 mg/kg), vita...
#1Wen Li (Nantong University)H-Index: 1
#2Juan Liu (Nantong University)H-Index: 2
Last. Hui He (Nantong University)H-Index: 1
view all 10 authors...
Glioma multiforme (GBM) is the most common malignant primary brain tumors. Despite the considerable advances in GBM treatment, it is still one of the most lethal forms of brain tumor. New clinical biomarkers and therapeutic targets are immediately required. MicroRNAs (miRNAs) are a class of small, evolutionarily conserved noncoding RNAs and have emerged as the key regulators of many cancers. Here in this study, we showed that miR-674-5p was probably an important regulator of glioma cell growth. ...
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