Analytical Methods
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#1Fang Hu (ECUST: East China University of Science and Technology)H-Index: 1
#2Yunxia Huang (ECUST: East China University of Science and Technology)H-Index: 1
Last. Youjun Yang (ECUST: East China University of Science and Technology)H-Index: 19
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By combining a Hill-type pH probe and a pH-insensitive naphthalimide fluorophore, we synthesized a FRET-based ratiometric pH probe (PHHF), exhibiting a reduced pH transition width, representing a unique approach for development of sensitive probes for detection of biorelevant pH changes.
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#1Guo-Qi Zhang (Sichuan University)H-Index: 2
#2Yong-Sheng Li (Sichuan University)H-Index: 4
Last. Xiu-Feng Gao (Sichuan University)H-Index: 8
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Herein, cobalt and nitrogen co-doped carbon dots (Co–N-CDs) were fabricated via a one-pot hydrothermal approach. The obtained Co–N-CDs displayed peroxidase-like activity and fluorescence properties. It could catalyze the oxidization of guaiacol (GA) in the presence of hydrogen peroxide (H2O2), and thus, resulted in color change, accompanied by a new absorption peak in 470 nm. Owing to the inner filter effect, the oxidized product of GA (known as 2-PQ) largely absorbed the Co–N-CD fluorescence wh...
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#1Soogeun KimH-Index: 6
#2Wansun KimH-Index: 11
Last. Samjin ChoiH-Index: 22
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We report the development of a label-free, simple, and high efficiency breast cancer detection platform with multimodal biomarker analytic algorithms on a portable 785 nm Raman setup with an endoscopic Raman-lensed fiber optic probe. We propose a multimodal biomarker extraction algorithm (PCMA) implemented by combining a multivariate statistics principal component analysis (PCA) algorithm and a multivariate curve resolution-alternating least squares (MCR-ALS) computational model for extraction o...
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#2Vyacheslav M. Nekrasov (NSU: Novosibirsk State University)H-Index: 9
Last. Valeri P. Maltsev (NSU: Novosibirsk State University)H-Index: 15
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Analysis of blood platelets encounters a number of different preanalytical issues, which greatly decrease the reliability and accuracy of routine clinical analysis. Modern hematology analyzers determine only four parameters relating to platelets. Platelet shape and dose-dependent activation parameters are outside the scope of commercial instruments. We used the original scanning flow cytometer for measurement of angle-resolved light scattering and the discrete dipole approximation for simulation...
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#1Xu-hao Sun (Qilu University of Technology)
#2Qiu-bo Wang (Qilu University of Technology)H-Index: 3
Last. Zhao-e Liu (SDU: Shandong University)H-Index: 1
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Thermo-responsive nanogels, poly(NIPAM–AAM) were prepared by a facile method of free radical one-pot precipitation based on monomeric N-isopropylacrylamide (NIPAM). At the same time, surface carboxyl group-modified fluorescent conjugated polymer nanoparticles (PNPs–COOH) were immobilized in the nanogel networks by hydrogen bonding to show bright green photoluminescence and outstanding thermo-responsive properties with a typical two-phase Tai Chi structure. Poly(NIPAM–AAm)–PNPs–COOH displays a la...
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#1Wuping Liu (Ha Tai: Xiamen University)H-Index: 1
#2Jingjing Xu (Ha Tai: Xiamen University)H-Index: 10
Last. Jianghua Feng (Ha Tai: Xiamen University)H-Index: 14
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Obesity is a key component of metabolic syndrome and is precipitated by complex interactions between multiple environmental and genetic factors. The integration of multi-level bioinformation is needed to understand the altered endogenous molecule and metabolic mechanisms. In this study, an integrated analytical strategy was proposed by combining microarray data from a gene expression omnibus database and in vitro serum metabolomic data to unearth bioinformation associated with cafeteria diet ind...
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#2Merve OzcanH-Index: 1
Last. Aytekin UzunogluH-Index: 11
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The surface of graphene was decorated with nickel/nickel oxide/nickel-boron particles to develop high-performance electrochemical sensors. The nanohybrid structures were prepared via a one-step reduction method under an oxygen-rich atmosphere to obtain an oxide phase besides metallic nickel nanoparticles. In addition, the use of NaBH4 as the reducing agent enabled simultaneous formation of Ni-B species on the graphene surface. XRD, XPS, TEM, Raman, and TGA analyses were implemented to characteri...
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#1Lin Yuan (Anda: Anhui University)H-Index: 57
#2Dong Wang (Anda: Anhui University)
Last. Zhengjie Liu (Anda: Anhui University)H-Index: 9
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Mitochondrial matrix contains numerous metabolism-related proteins/enzymes and nucleic acids, which play key roles in the process of energy generation and signal transduction. The fluctuations in mitochondrial biomacromolecular levels lead to the changes in the mitochondrial matrix viscosity; therefore, real-time measuring the mitochondrial matrix viscosity is of great significance for the in-depth understanding of the mitochondrial physiology and pathobiology. However, investigations are limite...
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We present a facile paper-based microfluidic device fabrication technique leveraging off-the-shelf carbon paper for the deposition of hydrophobic barriers using a novel "stencil scratching" method. This exceedingly frugal approach (0.05$) requires practically no technical training to employ. Hydrophobic barriers fabricated using this approach offer a width of 3 mm and a hydrophilic channel width of 849 μm, with an ability to confine major aqueous solvents without leakage. The utility of the devi...
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#1Ting Li (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
#2Qingqing Wu (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
Last. Zhigang Hu (Nanjing Medical University)H-Index: 4
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Background null the level of serum antibodies against the M-type phospholipase A2 receptor (anti-PLA2R-IgG) is closely related to the disease activity of idiopathic membranous nephropathy (IMN). Therefore, the establishment of a sensitive and rapid method for detecting anti-PLA2R-IgG will be beneficial for the differential diagnosis of IMN. null Methods null magnetic microspheres coupled with the PLA2R antigen were used to capture anti-PLA2R-IgG in serum samples, and europium-labeled goat anti-h...
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Top fields of study
Analytical chemistry
Detection limit
Mass spectrometry
High-performance liquid chromatography
Chemistry
Materials science
Chromatography
Fluorescence