Cancer Biology & Therapy
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The Ubiquitin-Proteasome System plays a central role in signal transduction associated with stress, in the skin in particular by the control of NF-κB pathways. Under normal conditions, the inhibitory protein IκB is phosphorylated by kinases, then ubiquitinated and ends up at the proteasome to be degraded. The present short review discusses recent progress in the inhibition of NF-κB activation by proteasome inhibitors prevents the degradation of protein IκB, which accumulates in the cytosol, and ...
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#1Zheng Weicheng (Nantong University)
#2Qingfeng Xue (Nantong University)
Last. Wenyu Shi (Nantong University)H-Index: 4
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Follicular lymphoma (FL) accounts for approximately 35% of all non-Hodgkin lymphomas and can progress to diffuse large B cell lymphoma (DLBCL) at a rate of 2% per year. Here, we present a 56-year-old female patient who was diagnosed with grade 3a FL. Further pathological investigation revealed that the lymphoma had transformed into DLBCL following six courses of R-CHOP regimen, and further disease progression was observed after two courses of R2-GemOx. We ultimately failed to collect hematopoiet...
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#1Masashi Idogawa (Sapporo Medical University)H-Index: 22
#2Masayo Koizumi (Sapporo Medical University)
Last. Takashi Tokino (Sapporo Medical University)H-Index: 81
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We often encounter situations in which data from the TCGA that have been analyzed in papers we read or reviewed cannot be reproduced, even when TCGA datasets are used, especially in survival analyses. Therefore, we attempted to confirm the data source for TCGA survival analysis and found that several websites used to analyze the survival data of TCGA datasets inappropriately handle the survival data, causing differences in statistical analyses. This causes the misinterpretation of results becaus...
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#1Ruiqing Li (Soochow University (Suzhou))
#2Jiejing Chen (YZU: Yangzhou University)
Last. Guoqin Jiang (Soochow University (Suzhou))
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Cisplatin is an effective chemotherapeutic agent in facilitating the inhibition of proliferation, migration, and invasion in cancerous cells. However, the detailed mechanism of the regulation by cisplatin of human breast cancer cells is still unclear. This study aimed to investigate the mechanism of kruppel-like factor 2 (KLF2) transcription factor in cisplatin therapy for breast cancer. RT-qPCR was performed to quantify the expression of KLF2 and WEE1 in clinical tissue samples from breast canc...
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#1Ifeanyichukwu O. Nwosu (BYU: Brigham Young University)H-Index: 2
#2Stephen R. Piccolo (BYU: Brigham Young University)H-Index: 16
Scholarly requirements have led to a massive increase of transcriptomic data in the public domain, with millions of samples available for secondary research. We identified gene-expression datasets representing 10,214 breast-cancer patients in public databases. We focused on datasets that included patient metadata on race and/or immunohistochemistry (IHC) profiling of the ER, PR, and HER-2 proteins. This review provides a summary of these datasets and describes findings from 32 research articles ...
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#1David Hsiehchen (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
#2Magdalena Espinoza (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Muhammad Shaalan Beg (UTSW: University of Texas Southwestern Medical Center)H-Index: 19
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Circulating tumor DNA (ctDNA) is utilized for molecular profiling of cancers, and is under investigation for a growing number of applications based on the assumption that ctDNA levels faithfully reflect disease burden. Our objective was to investigate whether patient and tumor characteristics may impact ctDNA detection or levels and the prognostic significance of ctDNA levels or mutations. We performed a retrospective cohort analysis of a comprehensively annotated cohort of 561 patients at a Nat...
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#1Jun Yin (XMU: Xinjiang Medical University)
#2Hai-Yan Huang (XMU: Xinjiang Medical University)
Last. Li Li (XMU: Xinjiang Medical University)
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Ovarian cancer is a fatal gynecologic tumor, and conventional treatment is mainly limited by chemoresistance. The mechanism contributing to chemoresistance in ovarian cancer has yet to be established. This study aimed to investigate the specific role of circ_C20orf11 in regulating chemoresistance to cisplatin (DDP)in ovarian cancer. We first established two DDP-resistant ovarian cancer cell lines. Then, we identified the effect of circ_C20orf11 on specific cellular characteristics (proliferation...
1 CitationsSource
#1Li Pan (UMB: University of Maryland, Baltimore)H-Index: 2
#2Ruijie Zhang (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Jiayuh Lin (UMB: University of Maryland, Baltimore)H-Index: 15
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Persistent activation of signal transducer and activator of transcription 3 (STAT3) is frequently reported in cancers and plays important roles in tumor progression. Therefore, directly targeting p...
1 CitationsSource
#1Weilu Kuang (CSU: Central South University)
#2Wuzhong Jiang (CSU: Central South University)
Last. Zhengzheng Liu (CSU: Central South University)
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A maximal surgical resection followed by radiotherapy and chemotherapy with temozolomide (TMZ) as the representative agent is the standard therapy for gliomas. However, tumor cell resistance to radiotherapy and chemotherapy leads to poor prognosis and high mortality in patients with glioma. In the present study, we demonstrated that JARID2 was downregulated and CCND1 was upregulated within glioma tissues of different grades and glioma cells. In tissue samples, JARID2 was negatively correlated wi...
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#1Osamu Maehara (Hokkaido University)H-Index: 10
#2Goki Suda (Hokkaido University)H-Index: 16
Last. Takuya Sho (Hokkaido University)H-Index: 15
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Fibroblast growth factors (FGFs) and their receptors (FGFRs) are important for signaling to maintain cancer stem-like cells (CSCs) in esophageal squamous cell carcinoma (ESCC). However, which FGF receptor, 1, 2, 3, 4, and L1, is essential or whether FGFRs have distinct different roles in ESCC-CSCs is still in question. This study shows that FGFR2, particularly the IIIb isoform, is highly expressed in non-CSCs. Non-CSCs have an epithelial phenotype, and such cells are more differentiated in ESCC....
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