Pediatric Neurology
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#1Fatema Al Amrani (Sultan Qaboos University)
#2Guillaume Sébire (Montreal Children's Hospital)H-Index: 15
Last. Christine Saint-Martin (Montreal Children's Hospital)H-Index: 12
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Abstract: null null Background null Identifying antepartum versus intrapartum timing and the cause of neonatal encephalopathy (NE) often remains elusive due to our limited understanding of the underlying pathophysiological processes and lack of appropriate biomarkers. null null null Objectives null This retrospective observational study describes a case series of term newborns with NE who displayed a recognizable magnetic resonance imaging (MRI) pattern of immediately post-natal brain abnormalit...
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Last. Catherine A. Smith (Silver Spring Networks)
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Abstract null null Background null Tuberous Sclerosis Complex International (TSCi) is a consortium of organizations that supports individuals with tuberous sclerosis complex (TSC) around the world. To improve care for TSC on a global level, TSCi identified the need to expand understanding about existing resources available in other countries, what individuals and caregivers value in TSC care, key gaps between needs and reality in each country, and ways these gaps can be addressed by advocacy org...
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#1Elena Martinez-Cayuelas (UAM: Autonomous University of Madrid)
#2Beatriz Rodríguez-Morilla (University of Murcia)
Last. Teresa Gavela-Pérez (UAM: Autonomous University of Madrid)H-Index: 9
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Abstract null null Sleep problems (SPs) are a prevalent comorbidity in autism spectrum disorder (ASD) with a multifactorial basis in which circadian misalignment have been described. A cross-sectional study was conducted including 52 children and adolescents with ASD (9.85 ± 3.07) and 27 children and adolescent controls with normal intellectual functioning (8.81 ± 2.14). They were matched for age, sex and body mass index and all were drug-naive. An ambulatory circadian monitoring (ACM) device wa...
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#1Nina F. Schor (NIH: National Institutes of Health)H-Index: 2
#2Diana W. Bianchi (NIH: National Institutes of Health)H-Index: 88
Neurodegenerative disorders are characterized by neuronal loss, usually in late life. But recently, abnormalities of proteins implicated in neurodegenerative disorders have been identified in disorders of childhood, raising the possibility that clues to susceptibility to and prevention of neurodegenerative disorders may be identifiable before symptoms of disease arise. This review leverages these new and evolving findings to test our hypothesis, first proposed in 2010, that proteins implicated i...
1 CitationsSource
#1Montaha Almudhry (King Fahad Specialist Hospital)
#2Manar Alotaibi (King Fahad Specialist Hospital)
Last. Ali Mir (King Fahad Specialist Hospital)H-Index: 3
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#1S. Katie Z. Ihnen (Cincinnati Children's Hospital Medical Center)
#2Jamie K. Capal (UNC: University of North Carolina at Chapel Hill)
Last. Darcy A. Krueger (Cincinnati Children's Hospital Medical Center)H-Index: 25
view all 9 authors...
Summary: null null Objective null Epilepsy in Tuberous Sclerosis Complex (TSC) typically presents with early onset, multiple seizure types, and intractability. However, variability is observed amongst individuals. Here, detailed individual data on seizure characteristics collected prospectively during early life were used to define epilepsy profiles in this population. null null null Methods null Children ages 0-36 months were followed longitudinally. Caregivers kept daily seizure diaries, inclu...
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#1Olivia J. Veatch (KU: University of Kansas)
#2Beth A. MalowH-Index: 63
Last. Daniel G. GlazeH-Index: 57
view all 22 authors...
BackgroundAdequate sleep is important for proper neurodevelopment and positive health outcomes. Sleep disturbances are more prevalent in children with genetically determined neurodevelopmental syndromes compared to typically developing counterparts. We characterize sleep behavior in Rett (RTT), Angelman (AS) and Prader-Willi (PWS) syndromes in order to identify effective approaches for treating sleep problems in these populations. We compared sleep-related symptoms across individuals with these ...
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#1Maryam Nabavi Nouri (UWO: University of Western Ontario)
#2Maria ZakH-Index: 6
Last. Robyn Whitney (McMaster University)H-Index: 9
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Abstract: null Tuberous Sclerosis Complex (TSC) is a rare autosomal dominant condition that affects multiple body systems. Disruption of the mammalian target of rapamycin (mTOR) pathway results in abnormal cell growth, proliferation, protein synthesis and cell differentiation and migration in TSC. In the central nervous system, mTOR disruption is also believed to influence neuronal excitability and promote epileptogenesis. Epilepsy is the most common neurological manifestation of TSC and affects...
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#1Jacob Andersson (Uppsala University)H-Index: 4
#2Johan Wikström (Uppsala University)H-Index: 24
Last. Ingemar Thiblin (Uppsala University)H-Index: 19
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BACKGROUND Acute subdural hematoma (ASDH) and chronic subdural hematoma (CSDH) in infants have been regarded as highly specific for abuse. Other causes of CSDH have not been investigated in a large population. PURPOSE The purpose of this study was to investigate to what extent external hydrocephalus is present in infants with ASDH and CSDH undergoing evaluation for abuse. MATERIAL AND METHODS Eighty-five infants suspected of being abused, with ASDH (n = 16) or CSDH (n = 69), were reviewed regard...
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#1Cecilia JobstH-Index: 6
#2Samantha Justina D'Souza (U of T: University of Toronto)H-Index: 1
Last. Darcy Fehlings (U of T: University of Toronto)H-Index: 39
view all 7 authors...
Abstract null Background null Children with hemiplegic cerebral palsy (HCP) experience upper limb somatosensory and motor deficits. While constraint-induced movement therapy (CIMT) improves motor function, its impact on somatosensory function remains under-investigated. null Objective null To evaluate somatosensory perception and related brain responses in children with HCP, before and after a somatosensory enhanced CIMT protocol, as measured using clinical sensory and motor assessments and magn...
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