Cell Transplantation
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#1Daniel LysákH-Index: 14
#2Michaela Brychtova (Charles University in Prague)H-Index: 1
Last. Monika Holubova (Charles University in Prague)H-Index: 7
view all 8 authors...
Cryopreserved haematopoietic progenitor cells are used to restore autologous haematopoiesis after high dose chemotherapy. Although the cells are routinely stored for a long period, concerns remain ...
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#1Xiaohui Fu (ZJU: Zhejiang University)H-Index: 3
#2Yimiao Feng (ZJU: Zhejiang University)H-Index: 2
Last. Yanzhen Zhang (ZJU: Zhejiang University)H-Index: 1
view all 4 authors...
Background:Dental pulp stem cells (DPSCs) are a unique source for future clinical application in dentistry such as periodontology or endodontics. However, DPSCs are prone to apoptosis under abnorma...
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#1Xi Sun (SJTU: Shanghai Jiao Tong University)
#2Qiaomei He (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Xiujie Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 1
view all 13 authors...
Acute graft-versus-host disease (aGVHD) is one of the most common complications of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Janus kinase (JAK) inhibitors are considered as reliable and promising agents for patients with aGVHD. The prophylactic and therapeutic effects of SHR0302, a novel JAK inhibitor, were evaluated in aGVHD mouse models. The overall survival (OS), progression-free survival (PFS), bodyweight of mice, GVHD scores were observed and recorded. The bone marrow ...
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Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Increasing evidence suggests that long non-coding RNAs (lncRNAs) function in the tumorigenesis of NSCLC. LINC00958, a newly identified lncRNA, has been reported to be closely linked to tumorigenesis in several cancers. However, its specific role in NSCLC remains unclear. In this study, we determined the expression of LINC00958 in NSCLC by RT-qPCR analysis and evaluated cell proliferation and migration by CCK-8 and transwe...
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#1Zhen Li (JNU: Jinan University)H-Index: 4
#2Lina Yang (DUT: Dalian University of Technology)H-Index: 1
Last. Shuangping Liu (DUT: Dalian University of Technology)H-Index: 8
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Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer. However, the detail mechanism about the potential role of VPA on the Warburg effect in breast cancer remains unclear. In this study, we highlight that VPA significantly attenuates the Warburg effect by decreasing the expression of pyruvate kinase M2 isoform (PKM2), lead...
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#1Lauren M Timmins (RU: Rutgers University)H-Index: 1
#2Alexandra Burr (RU: Rutgers University)H-Index: 1
Last. Biju Parekkadan (RU: Rutgers University)H-Index: 23
view all 11 authors...
When considering the development pathway for a genetically modified cell therapy product, it is critically important that the product is engineered consistent with its intended human use. For scientists looking to develop and commercialize a new technology, the decision to select a genetic modification method depends on several practical considerations. Whichever path is chosen, the developer must understand the key risks and potential mitigations of the cell engineering approach. The developer ...
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#1María Belén Palma (CONICET: National Scientific and Technical Research Council)H-Index: 1
#2Carlos Luzzani (CONICET: National Scientific and Technical Research Council)H-Index: 14
Last. Marcela Nilda García (UNLP: National University of La Plata)H-Index: 8
view all 11 authors...
In normal physiological conditions, restoration of a functional epidermal barrier is highly efficient; nevertheless, when it fails, one of the main consequences is a chronic ulcerative skin defect, one of the most frequently recognized complications of diabetes. Most of these chronic venous ulcers do not heal with conventional treatment, leading to the appearance of infections and complications in the patient. Treatments based on the use of autologous mesenchymal stem cells (MSC) have been succe...
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#1Gulce Sari (Erasmus University Medical Center)H-Index: 4
#2Gertine W. van Oord (Erasmus University Medical Center)H-Index: 11
Last. Thomas Vanwolleghem (Erasmus University Medical Center)H-Index: 16
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Humanized liver mouse models are crucial tools in liver research, specifically in the fields of liver cell biology, viral hepatitis and drug metabolism. The livers of these humanized mouse models a...
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#1Piotr J. Bachul (U of C: University of Chicago)H-Index: 7
#2Karolina Golab (U of C: University of Chicago)H-Index: 9
Last. Piotr Witkowski (U of C: University of Chicago)H-Index: 28
view all 22 authors...
A recent randomized, multicenter trial did not show benefit of a CXCR1/2 receptor inhibitor (Reparixin) when analysis included marginal islet mass (>3,000 IEQ/kg) for allotransplantation and when i...
3 CitationsSource
#1Er-Hu Wei (Zhengzhou University)H-Index: 1
#2Xiao Fang (Zhengzhou University)
Last. Dan Gao (Zhengzhou University)
view all 8 authors...
Pneumonia is a serious respiratory tract infection disease in children, which threatens to the health or life of children patients. Ginsenoside Rb1 (Rb1) is a principle active ingredient extracted from the root of Panax notoginseng (Burk.) F.H. Chen with anti-inflammatory effect. Our study aimed to determine the effects and molecular mechanisms of Rb1 on lipopolysaccharide (LPS)-induced inflammatory injury of lung fibroblasts WI-38 cells. Cell viability and apoptosis were evaluated by CCK-8 and ...
1 CitationsSource
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