Biological & Pharmaceutical Bulletin
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#1Asami Mori (Kitasato University)H-Index: 20
#2Ryo Namekawa (Kitasato University)H-Index: 2
Last. Tsutomu Nakahara (Kitasato University)H-Index: 27
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An electrical communication between the endothelial and smooth muscle cells via gap junctions, which provides the signaling pathway known as endothelium-dependent hyperpolarization (EDH), plays a crucial role in controlling the vascular tone. In this study, we investigated the role of gap junctions in the acetylcholine (ACh)-induced EDH-type dilation of rat retinal arterioles in vivo. The dilator response was evaluated by measuring the diameter of retinal arterioles. Intravitreal injection of ga...
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#1Hiromi Tsushima (Kinjo Gakuin University)H-Index: 2
#2Kazuyo Yamada (Kinjo Gakuin University)H-Index: 6
Last. Sumiko Abe-Dohmae (Chubu University)H-Index: 29
view all 6 authors...
The physical characteristics and behavior of the ATP-binding cassette (ABC) A1, A7, and apolipoprotein (apo) E knockout (KO) mice with lipid transport dysfunction were investigated. These KO mice exhibited adequate growth, and their body masses increased steadily. No remarkable changes were observed in their blood pressure and heart rate. However, there was a slight increase in the heart rate of the ABCA7 KO mice compared with that of the wild-type (WT) mice. ABCA1 and apoE KO mice showed hypo- ...
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#1Yoshitaka Saito (Hokkaido University)H-Index: 8
#2Yoh Takekuma (Hokkaido University)H-Index: 16
Last. Mitsuru Sugawara (Hokkaido University)H-Index: 28
view all 4 authors...
We have reported that a strict denosumab administration management system with oral calcium/vitamin D supplementation attenuates denosumab-induced hypocalcemia in 158 cancer patients with bone metastasis. In this report, 27.8% of the patients experienced hypocalcemia, including 0.6% with grade 2. So far, the risk factors for ≥grade 2 hypocalcemia incidence have been identified in denosumab-treated cancer patients, including patients without calcium/vitamin D supplementation. Therefore, the prese...
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#1Masafumi Noda (Hiroshima University)H-Index: 15
#2Narandalai Danshiitsoodol (Hiroshima University)H-Index: 7
Last. Masanori Sugiyama (Hiroshima University)H-Index: 31
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A lactic acid bacterial strain, Lactobacillus plantarum SN35N, which has been isolated from the pear, secretes negatively charged acidic exopolysaccharide (EPS) to outside cells. We have previously found that the SN35N-derived acidic EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.35) promoting inflammation. The aim of this study is to find other health benefits of EPS. EPS has been found to exhibit an inhibitory effect against the influenza virus (Alphainfluenzavirus Influenza A ...
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#1Shengquan Hu (ZJU: Zhejiang University)
#2Jing Liu (ZJU: Zhejiang University)
Last. Xiaowu Dong (ZJU: Zhejiang University)H-Index: 19
view all 7 authors...
FMS-like tyrosine kinase 3 (FLT3) plays a very important role in regulating the proliferation, differentiation and survival of normal hematopoietic stem cells. Internal tandem duplications of the FLT3 gene (FLT3-ITD) mutations are present in 25% of all acute myeloid leukemia (AML) patients and are frequently associated with adverse clinical outcomes. Therefore, FLT3-ITD is a promising target for the treatment of AML. The use of covalent virtual screenings has shown that efficient rational approa...
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#1Yuto Sasaki (Hokkaido University)H-Index: 2
#2Kodai Saitoh (Hokkaido University)H-Index: 5
Last. Tadashi Matsuda (Hokkaido University)H-Index: 52
view all 8 authors...
Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis. After intravenous injection of concanavalin A (ConA), STAP-2 knock out (KO) mice showed more severe liver necrosis along with substantial lymphocyte infiltration compared to wild type (WT) mice. Serum alanine aminotransferase level...
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#1Masaru Doshi (Teikyo University)H-Index: 8
#2Shiro Watanabe (University of Toyama)H-Index: 13
view all 5 authors...
Thyroid hormones (THs) have been suggested to play an important role in both physiological and pathological events in the central nervous system. Hypothyroidism, which is characterized by low levels of serum THs, has been associated with aggravation of ischemic neuronal injuries in stroke patients. We hypothesized that administration of T3, the main active form of THs, may attenuate the ischemic neuronal injuries. In mice, global cerebral ischemia (GCI), which is induced by transient occlusion o...
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#1Misa Muraoka (Osaka University)H-Index: 3
#2Moeka Ohno (Osaka University)
Last. Kazumasa Hirata (Osaka University)H-Index: 36
view all 7 authors...
γ-Glutamylcysteine (γ-EC) has antioxidant properties similar to those of glutathione (GSH) and acts as its precursor in mammals. There are a few procedures for the production of γ-EC, such as chemical synthesis or enzymatic synthesis from glutamate and cysteine; however, they are very costly and not suitable for industrial production. A phytochelatin synthase-like enzyme derived from Nostoc sp. Pasteur Culture Collection 7120 (NsPCS) catalyzes the hydrolysis of GSH to γ-EC and glycine in the abs...
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#1Muhammad Novrizal Abdi Sahid (Ehime University)H-Index: 4
#2Shuang Liu (Ehime University)H-Index: 11
Last. Masaki Mogi (Ehime University)H-Index: 42
view all 5 authors...
Mast cell (MC) exocytosis is organized by prenylated protein, including Rab families. Among Rab proteins, Rab3a, Rab27a, and Rab11 are responsible for exocytosis arrangement. Rab3a and Rab27a are contributed to exocytosis by interacting with other exocytosis proteins. Zoledronate administration disrupted the Rab prenylation process that affected its interaction with other proteins, and finally, its function. The present study has investigated the effect of zoledronate on the histamine release (H...
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#1Masahiro KanekoH-Index: 5
#2Toru IizukaH-Index: 14
view all 3 authors...
Asthma is characterized by chronic inflammation of the airway mucosa. As Eucommia ulmoides Oliv. leaf extract (ELE) has been known to have anti-inflammatory properties, herein, we investigated the effect of ELE on interleukin (IL-) 8 production in A549 cells, a human airway epithelial cell line. The addition of ELE 1 h before tumor necrosis factor-alpha (TNFα) stimulation inhibited IL-8 production by A549 cells in a concentration-dependent manner. The addition of geniposidic acid, the main compo...
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