Biological & Pharmaceutical Bulletin
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#1Xu-Dong Ding (PRC: China Medical University (PRC))H-Index: 2
#2Yan-Yan Cao (PRC: China Medical University (PRC))H-Index: 1
Last. Guangyi Zhao (PRC: China Medical University (PRC))H-Index: 2
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Local anesthetic toxicity is closely related to neuronal death and activation of the inflammatory response. Dexmedetomidine (Dex) is an adrenergic α2 receptor agonist that can reduce the neurotoxicity induced by lidocaine. It also has anti-inflammatory effects. However, the mechanism underlying the neuroprotective effects of Dex against lidocaine-induced toxicity remains to be defined. We hypothesized that Dex exerts its neural protective effect through inhibiting inflammasome activation and thr...
Autophagy is an intracellular degradation system regulating cellular homeostasis. The two ubiquitin-like modification systems named the Atg8 system and the Atg12 system are essential for autophagy. Atg8 and Atg12 are ubiquitin-like proteins covalently conjugated with a phosphatidylethanolamine (PE) and Atg5, respectively, via enzymatic reactions. The Atg8-PE conjugate binds to autophagic membranes and recruits various proteins through direct interaction, whereas the Atg12-Atg5 conjugate recogniz...
#1Yasuhiro Nakamura (Teikyo University)H-Index: 1
Last. Ken Karasawa (Teikyo University)H-Index: 17
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Type I platelet-activating factor-acetylhydrolase (PAF-AH) forms a complex consisting of two catalytic subunits (α1 and/or α2) with a regulatory subunit (β). Although this protein was discovered as an enzyme that degrades an acetyl ester linked at the sn-2 position of platelet-activating factor (PAF), its physiological function remains unknown. In this study, to examine whether knockout mice lacking the catalytic subunits of this enzyme showed a different phenotype from that of wild-type mice, w...
#1Fang Zhang (NU: Nanjing University)H-Index: 1
#2Ye Liu (NU: Nanjing University)
Last. Zhiwei Wu (Ningxia University)H-Index: 14
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Herpes simplex virus-1 (HSV-1) infection of the eyes leads to herpes simplex virus keratitis (HSK), the main cause of infectious blindness in the world. As the current therapeutics for HSV-1 infection are rather limited and prolonged use of acyclovir (ACV)/ganciclovir (GCV) and in immunocompromised patients lead to the rise of drug resistant mutants, it underlines the urgent need for new antiviral agents with distinct mechanisms. Our study attempted to establish ras-related C3 botulinum toxin su...
#1Seira Nishibe-Toyosato (Fujita Health University)
#2Yosuke Ando (Fujita Health University)H-Index: 4
Last. Kazuyoshi Imaizumi (Fujita Health University)H-Index: 26
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Erlotinib is used to treat advanced non-small-cell lung cancer (NSCLC), the common serious adverse events are skin disorders. The dose intensity of erlotinib should be maintained as much as possible by an appropriate control of adverse events in order to maintain its efficacy. Therefore, the management of these adverse events related to skin disorders would enable a continuous erlotinib treatment without interruption and dose reduction. This study assessed the effect of pharmaceutical consultati...
#1Yuta Kyosei (Waseda University)H-Index: 1
#2Mayuri Namba (Waseda University)H-Index: 1
Last. Etsuro Ito (Waseda University)H-Index: 35
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Antigen tests for infectious diseases are inexpensive and easy-to-use, but the limit of detection (LOD) is generally higher than that of polymerase chain reaction (PCR) tests, which are considered the gold standard. In the present study, we combined a sandwich enzyme-linked immunosorbent assay (ELISA) with thionicotinamide-adenine dinucleotide (thio-NAD) cycling to improve the LOD of antigen tests for coronavirus disease 2019 (COVID-19). For recombinant nucleocapsid proteins of severe acute resp...
#1Wenbing Ying (WMU: Wenzhou Medical College)
#2Kesi Zheng (WMU: Wenzhou Medical College)
Last. Ouchen Wang (First Affiliated Hospital of Wenzhou Medical University)
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Pannexin 1 (PANX1) has been implicated in cancer emergence and progression. However, its roles in gastric cancer remain unclear. In the present study, the function and molecular mechanisms of PANX1 in gastric cancer were investigated in vitro. Two gastric cancer cell lines exhibiting low and high PANX1 expression (SNU-16 and HCG-27, respectively) were transfected using a PANX1-containing plasmid or PANX1 transcript-targeting short hairpin (sh)RNA. In addition, HCG-27 cells and PANX1-overexpressi...
#1Chiharu Yamaguchi (Taisho Pharmaceutical Co.)H-Index: 1
#2Daisuke Yamamoto (Taisho Pharmaceutical Co.)
Last. Akiko Takaoka (Taisho Pharmaceutical Co.)H-Index: 10
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Musculoskeletal and psychological complaints have increased with the widespread use of visual display terminals, and musculoskeletal pain is known to be closely related to stress. One method of experimentally inducing persistent muscle pain is repeated cold stress (RCS), and animals exposed to such stress exhibit a dysfunction in the descending pain inhibitory system. Acetaminophen (acetyl-p-aminophenol; APAP) is widely used to relieve several types of pain, including musculoskeletal pain, and i...
#1Yuto Nagasaki (Ridai: Tokyo University of Science)
#2Misato Abe (Chiba University)
Last. Kyohei Higashi (Ridai: Tokyo University of Science)H-Index: 21
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Honeybee larvae have been recognized as nutrient-rich food in many countries. Although glycogen, a storage form of glucose in animals, is synthesized in honeybee larvae, there is no information on the structure of glycan and its biological activity. In this study, we successfully extracted glycogen from honeybee larvae using hot water extraction and investigated the structure and biological activity of glycan. It was found that the molecular weight of glycogen from honeybee larvae is higher than...
#1Airi Yoshimoto (UTokyo: University of Tokyo)
#2Kotaro Yamashiro (UTokyo: University of Tokyo)H-Index: 1
Last. Nobuyoshi Matsumoto (UTokyo: University of Tokyo)H-Index: 7
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Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a melatonin MT1/MT2 receptor agonist, has recently been developed to modulate sleep-wake rhythms. To date, the sleep-promoting effect of ramelteon has been widely delineated, but whether ramelteon treatment physiologically influences cardiac function is not well understood. To address thi...
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Diabetes mellitus