Immunobiology
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#1Ritu Chakravarti (University of Toledo)H-Index: 17
Abstract null null The 14-3-3 proteins are known for their functions related to the cell cycle and play a prominent role in cancer-related diseases. Recent studies show that 14-3-3 proteins are also regulators of immune responses and are involved in the pathogenesis of autoimmune and infectious diseases. This focused review highlights the significant and recent studies on how 14-3-3 proteins influence innate and adaptive immune responses; specifically, their roles as immunogens and cytokine sign...
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#1Xueyang Zou (Jilin University)H-Index: 4
#2Yi Zhang (Jilin University)H-Index: 3
Last. Yi Li (Jilin University)H-Index: 7
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Abstract null null Autoimmune regulator (Aire) is a transcription factor that plays a pivotal role in the maintenance of immune tolerance. However, little is known about its roles in peripheral immune tolerance. Aire is predominantly expressed in dendritic cells (DCs) in the periphery. DCs with higher inducible costimulatory ligand (ICOSL) expression and interleukin (IL)-27 production have been reported highly suggesting its roles in inducing follicular helper T cells (TFH). Here we use Aire-ove...
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#1Aysan Moeinafshar (TUMS: Tehran University of Medical Sciences)
#2Niloufar Yazdanpanah (TUMS: Tehran University of Medical Sciences)H-Index: 3
Last. Nima Rezaei (TUMS: Tehran University of Medical Sciences)H-Index: 84
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Abstract null null Background null Dilated cardiomyopathy (DCM) is a condition involving dilation of cardiac chambers, which results in contraction impairment. Besides invasive and non-invasive diagnostic procedures, cardiac biomarkers are of great importance in both diagnosis and prognosis of the disease. These biomarkers are categorized into three groups based on their site; cardiomyocyte biomarkers, microenvironmental biomarkers and macroenvironmental biomarkers. null null null Aims null In t...
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#1Deise do Nascimento de Freitas (PUCRS: Pontifical Catholic University of Rio Grande do Sul)H-Index: 3
#2Caroline Franceschina (PUCRS: Pontifical Catholic University of Rio Grande do Sul)H-Index: 1
Last. Krist Helen Antunes (PUCRS: Pontifical Catholic University of Rio Grande do Sul)H-Index: 5
view all 13 authors...
Abstract null null Resolvin D1 (RvD1), which is biosynthesized from essential long-chain fatty acids, is involved in anti-inflammatory activity and modulation of T cell response. Memory CD8+ T cells are important for controlling tumor growth and viral infections. Exacerbated inflammation has been described as impairing memory CD8+ T cell differentiation. This study aimed to verify the effects of RvD1 on memory CD8+ T cells in vitro and in vivo in a respiratory virus infection model. Peripheral b...
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#1Isaura Isabelle Fonseca Gomes da Silva (UFPE: Federal University of Pernambuco)H-Index: 2
#2Alexandre Domingues Barbosa (UFPE: Federal University of Pernambuco)H-Index: 3
Last. Paula Sandrin-Garcia (UFPE: Federal University of Pernambuco)H-Index: 18
view all 7 authors...
Abstract null null Rheumatoid arthritis (RA) is a well-known chronic inflammatory disorder. Two molecular players act in the inflammation balance of the disease: MyD88 (Myeloid differentiation primary response 88) is related to TLR (Toll-like receptors) response and promotes the formation of myddosome complex resulting in increased inflammation; IRAK3 (Interleukin-1 receptor associated kinase 3) acts suppressing the myddosome complex thus decreasing inflammation. In this scenario, MYD88 and IRAK...
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#1Nashwa El-Khazragy (ASU: Ain Shams University)H-Index: 8
#2Mahfouz A. Abdel Aziz (Cairo University)H-Index: 2
Last. Marwa Ali Abd Elkhalek (ASU: Ain Shams University)
view all 11 authors...
Abstract null null T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10–15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene...
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#1Yau E (PSU: Pennsylvania State University)
#2Y. Chen (HUST: Huazhong University of Science and Technology)
Last. Sinisa Dovat (HUST: Huazhong University of Science and Technology)
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Abstract null null Macrophages play an important role in maintaining tissue homeostasis, from regulating the inflammatory response to pathogens to resolving inflammation and aiding tissue repair. The surfactant protein A (SP-A) receptor SP-R210 (MYO18A) has been shown to affect basal and inflammatory macrophage states. Specifically, disruption of the longer splice isoform SP-R210L/MYO18Aα renders macrophages hyper-inflammatory, although the mechanism by which this occurs is not well understood. ...
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#1Rasmita Khatonier (RMRC: Regional Medical Research Centre)
#2Giasuddin Ahmed (Gauhati University)H-Index: 13
Last. Abdul M. Khan (ICMR: Indian Council of Medical Research)H-Index: 4
view all 5 authors...
Abstract null null Visceral leishmaniasis (VL) or Kala-azar is a vector borne protozoan infection caused by Leishmania donovani in the Indian subcontinent mainly India, Nepal and Bangladesh. It is a major public health problem in these countries mostly affecting the socio-economically poor population. Leishmaniasis ranks the third most important disease after malaria and filariasis but is still considered as one of the neglected tropical diseases of the world. For development of better therapeut...
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#1Swati Sharma (CBT: Institute of Genomics and Integrative Biology)H-Index: 3
#2Srishti Vashisht (CBT: Institute of Genomics and Integrative Biology)
Last. Naveen Arora (CBT: Institute of Genomics and Integrative Biology)H-Index: 19
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Abstract null null Background null Immune epitopes of allergens are pivotal for development of novel diagnostic and therapeutic modalities. Present study aims to identify antigenic determinants of Per a 5, a clinically relevant cross reactive cockroach allergen. null null null Methods null The three dimensional structure of Per a 5 was modelled using Modeller 9v11 software. A combination of sequence and structure based computational tools were employed for predicting B cell epitopes. Epitopes we...
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#1Johanna Wagner (UCSF: University of California, San Francisco)H-Index: 7
#2Svenja Leicht (University of Würzburg)
Last. Ingo Klein (University of Würzburg)H-Index: 12
view all 9 authors...
Regulatory T cells (Tregs) maintain immune homeostasis by regulating the activation of other immune cells. Preclinical studies show that the infusion of Tregs can promote immunological tolerance to allografts and prevent or cure multiple autoimmune diseases. However, Treg therapy is limited by high numbers of cells required to induce tolerance. In this study, we aimed at improving the in vitro expansion of sort purified mouse Tregs using the CD28 Superagonist (CD28-SA) D665 and comparing it to t...
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